Does quantitative serologic testing for Helicobacter pylori predict peptic ulcer disease in cirrhosis?

Abstract:

BACKGROUND:Helicobacter Pylori is strongly associated with peptic ulcer disease. A correlation between high IgG serum antibody concentrations and a clinical diagnosis has been reported. It has been recognized that peptic ulcer disease occurs with increased frequency in cirrhosis. In this study, we attempted to establish a relation between the magnitude of serum IgG antibody to H pylori and the endoscopic diagnoses in H pylori-infected cirrhotic patients. METHODS:All cirrhotic patients who had undergone esophagogastroduodenoscopy with a positive H pylori IgG serology and who did not receive anti-H pylori treatment or take medications noxious to the gastroduodenal mucosa were included in the study. H pylori IgG serology was determined by an enzyme-linked immunosorbent assay with values of greater than 50 units/mL being seropositive. The functional reserve of cirrhosis was classified by modified Pugh-Child criteria. RESULTS:One hundred four seropositive cirrhotic patients were recruited. The serum IgG titers ranged from 51 to 1200 units/mL with a peak frequency at 50 to 99 units/mL (35. 6%). Statistical analysis did not reveal any relation between the quantitative H pylori IgG values and the endoscopic diagnoses, which included gastric ulcers, duodenal ulcers, gastroduodenal erosions, and normal findings. CONCLUSIONS:In cirrhosis, the magnitude of H pylori IgG serology cannot be used to predict the presence or absence of peptic ulcer disease.

journal_name

Gastrointest Endosc

authors

Tsai CJ

doi

10.1053/ge.1999.v50.98595

keywords:

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

381-6

issue

3

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(99)00449-6

journal_volume

50

pub_type

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