Abstract：
BACKGROUND:Intravenous sedation/analgesia for colonoscopy is accompanied with certain risks and postprocedure drowsiness. We sought to determine whether inhaled nitrous oxide (Entonox: 50% nitrous oxide, 50% oxygen) provides adequate analgesia for colonoscopy and the impact of this agent on recovery. METHODS:All patients undergoing outpatient colonoscopy were considered for the study (n = 248) except those with previous colonic resection. Data for patients unsuitable for randomization (n = 58) and those who declined to participate (n = 88) were also analyzed. RESULTS:One hundred two patients were randomized to receive inhaled Entonox alone (n = 56) or intravenous midazolam and meperidine (n = 46). Forty-nine (88%) patients randomized to Entonox underwent complete colonoscopy without conversion to intravenous medications. Entonox patients reported more pain (p < 0.0001), tolerated colonoscopy less well (p < 0.0001), were less satisfied (p = 0.01), and less willing to undergo colonoscopy again under the same circumstances (p = 0.04). Of patients receiving intravenous medication, 91% found colonoscopy less unpleasant and 9% as unpleasant as anticipated; this compares with 52% and 21% Entonox patients, respectively, and an additional 27% Entonox patients who found colonoscopy more unpleasant than anticipated. Recovery was faster among Entonox patients (median 30 versus 60 minutes, p < 0.0001). CONCLUSION:Entonox is less effective than midazolam with meperidine for colonoscopy but is acceptable in many patients and allows faster recovery.
journal_name
Gastrointest Endoscjournal_title
Gastrointestinal endoscopyauthors
Forbes GM,Collins BJdoi
10.1016/s0016-5107(00)70354-3keywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
271-7issue
3eissn
0016-5107issn
1097-6779pii
S0016-5107(00)70354-3journal_volume
51pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:Although endoscopic hemoclip therapy is widely used in the treatment of GI bleeding, there are few prospective trials that assess its efficacy. This study evaluated the efficacy and safety of hemoclip placement and distilled water injection for the treatment of high-risk bleeding ulcers. METHODS:Seventy-nin...
journal_title：Gastrointestinal endoscopy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1067/mge.2003.103
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:Although the initial rate of hemostasis achieved by endoscopic epinephrine injection for peptic ulcer bleeding is high, bleeding recurs in 14.6% to 35.5% of patients. The aim of this study was to compare rates of recurrent bleeding after endoscopic injection of two different volumes of epinephrine in patient...
journal_title：Gastrointestinal endoscopy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0016-5107(04)02279-5
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Acute GI bleeding is a life-threatening complication of warfarin therapy. Acute GI bleeding in patients with an international normalized ratio of 4.0 or greater (supratherapeutic) is often attributed to trivial mucosal lesions. The aim of the study was to determine the frequency of potentially significant le...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:It has been reported that the occurrence of acute cholangitis is common, especially when the self-expanding metal stent (SEMS) is placed across the main duodenal papilla. OBJECTIVE:To determine the incidence of duodenobiliary reflux and acute cholangitis after placement of SEMSs across the main duodenal pap...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2008.12.054
更新日期：2009-08-01 00:00:00
abstract：:Fifty cirrhotic patients with esophageal varices underwent endoscopic treatment in a prospective randomized trial carried out to compare variceal ligation with injection sclerotherapy, with respect to safety, efficacy, and complications in the initial session. Twenty-five patients each were treated using endoscopic va...
journal_title：Gastrointestinal endoscopy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0016-5107(93)70050-4
更新日期：1993-03-01 00:00:00
abstract：:Biliary stent blockage by adherence of bacteria and formation of biofilm is a major problem in endoscopic stenting procedures. We have investigated bacterial adherence to hydrophilic polymer (Hydromer)-coated polyurethane stents in stationary and perfusion experiments. Adherence of gram negative and gram positive orga...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(93)70220-5
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:There is increasing interest in natural orifice surgery (NOS). Because the lumen of the appendix is connected to the cecum, a minimally invasive method for removing the appendix by colonoscopy may be feasible. OBJECTIVES:Our purpose was to design, develop, and test new devices for inverting and removing the...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2008.02.024
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND AND AIMS:EMR and endoscopic submucosal dissection (ESD) are widely accepted in Asia for treatment of early gastric cancer (EGC). Few studies have examined lymph node (LN) metastasis of EGC in Western populations. We sought to examine EGC and LN metastasis in a heterogeneous Western population. METHODS:Patie...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2015.10.039
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Gastrointestinal graft-versus-host disease after allogeneic hematopoietic cell transplantation presents a range of upper gastrointestinal endoscopic and histologic abnormalities. Recognition of these sometimes subtle abnormalities is critical for directing specific therapy. METHODS:Endoscopic and histologic...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(99)70390-1
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:Endoscopic nasobiliary drainage (NBD) for the treatment of acute cholangitis is an accepted method. A recently developed ultrathin transnasal videoendoscope is minimally invasive, even for patients who are critically ill. OBJECTIVE:To evaluate the clinical efficacy and safety of 1-step NBD by transnasal vid...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2007.11.050
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Ileoscopy is the criterion standard for mucosal lesions of terminal ileum but is performed in 5% of colonoscopy activity, and the need for training is undefined. OBJECTIVE:To assess the learning curve and skill-keeping line of ileoscopy. DESIGN:Prospective randomized study. SETTING:Single GI endoscopy uni...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.gie.2005.09.029
更新日期：2006-02-01 00:00:00
abstract：:The role of noninvasive evaluation of the common bile duct combined with selective preoperative endoscopic retrograde cholangiography and sphincterotomy was prospectively evaluated in 1390 consecutive patients subjected to laparoscopic cholecystectomy. Preoperative common bile duct testing included liver chemistries, ...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(95)70235-0
更新日期：1995-07-01 00:00:00
abstract：:In studying the side effects of sclerosants injected into the gastric submucosa in dogs (N = 7), we noted that 3 ml of absolute ethanol induced a large gastric ulceration. We describe the time course of change in the ulcer size, and suggest that such ulceration can be used for the endoscopic assessment of factors impo...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(91)70721-9
更新日期：1991-05-01 00:00:00
abstract：BACKGROUND:High-frequency catheter probe US provides detailed images when the scanning plane is perpendicular to the area of interest and the latter is within the focal zone. A multibending endoscope has been developed that has two bending sections that can be deflected independently. The aim of this study was to deter...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(04)01270-2
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:A combination of midazolam and opioid is usually used to achieve sedation and analgesia during colonoscopy. Two commonly used opioids are meperidine and fentanyl, but few studies have compared their efficacy. OBJECTIVE:This randomized trial aimed to compare the efficacy and recovery time of 2 sedation regim...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.gie.2008.09.033
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Remote control of capsule endoscopes might allow reliable inspection of the human stomach. OBJECTIVE:To assess the safety and efficacy of manipulation of a modified capsule endoscope with magnetic material (magnetic maneuverable capsule [MMC]) in the human stomach by using a handheld external magnet. DESIG...
journal_title：Gastrointestinal endoscopy
pub_type： 临床试验,杂志文章
doi：10.1016/j.gie.2010.08.053
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Confocal laser endomicroscopy (CLE) may be used to diagnose gastric cancer and intestinal metaplasia, but the impact of CLE experience on the accuracy of confocal diagnosis of gastric cancer and intestinal metaplasia is not clear. OBJECTIVE:To establish the sensitivity, specificity, and intragroup interobse...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2011.01.068
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Pancreatic/peripancreatic tuberculosis (TB) is a very rare clinical entity, even in countries with high incidences of TB. The diagnosis of pancreatic/peripancreatic TB with EUS-guided FNA (EUS-FNA) remains a diagnostic challenge because of limitations of the endoscopists' expertise on this condition. OBJECT...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2008.10.007
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND AND AIMS:Chromoendoscopy (CE) has been shown to generate both a superior diagnostic yield and dysplasia detection rate than conventional white-light endoscopy and requires a high-quality bowel preparation. The aim of this study was to identify predictors of the ability to perform CE in patients with inflamma...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2018.09.039
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:The differential diagnosis between benign and malignant polyps of the gallbladder (GB) is often challenging. OBJECTIVES:To evaluate whether contrast-enhanced harmonic EUS (CEH-EUS) might be an accurate method for discriminating malignant GB polyps from benign polyps. DESIGN:Observational study. SETTING:Te...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2013.03.1328
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Endoscopic ultrasound (EUS) guided fine-needle aspiration (FNA) of pancreatic lesions is being increasingly used. Our aim was to determine the safety, accuracy, and clinical utility of EUS-guided FNA in both the diagnosis and staging of pancreatic cancer. METHODS:Forty-four patients (24 men/20 women) had EU...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(97)70149-4
更新日期：1997-05-01 00:00:00
abstract：:Forty-six patients who underwent piecemeal resection of large, sessile villous adenomas followed by immediate laser photoablative therapy are presented. In contrast to previously published series utilizing laser alone, prior snare resection of such lesions provides copious tissue for histologic analysis, decreases the...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(89)72793-0
更新日期：1989-07-01 00:00:00
abstract：:Chronic radiation proctopathy is a common sequela of radiation therapy for malignancies in the pelvic region. A variety of medical and endoscopic therapies have been used for the management of bleeding from chronic radiation proctopathy. In this guideline, we reviewed the results of a systematic search of the literatu...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章,实务指引
doi：10.1016/j.gie.2019.04.234
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:The Rockall scoring system was developed in unselected patients, the majority of whom did not receive endoscopic therapy. The aim of this study was to assess the validity of the Rockall system in high-risk patients who undergo endoscopic therapy for peptic ulcer hemorrhage. METHODS:Rockall scores were calcu...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.gie.2005.06.042
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND AND AIMS:In patients who undergo cholecystectomy after endoscopic common bile duct (CBD) stone extraction, CBD stones found postoperatively could be problematic. This study aimed to investigate the incidence and risk factors of postoperative CBD stones after cholecystectomy. METHODS:A total of 278 patients ...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2020.06.060
更新日期：2020-06-26 00:00:00
abstract：BACKGROUND:Monopolar hot biopsy forceps (HBF), bipolar HBF, and cold biopsy forceps (CBF) followed by bipolar electrocoagulation are used clinically to simultaneously perform a biopsy and coagulate diminutive colon polyps and angiomata. Our purpose was to conduct a randomized, controlled study to evaluate the safety of...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(95)70013-7
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Management of anastomotic biliary strictures after liver transplantation deserves optimization. OBJECTIVE:To evaluate placement and removal of partially covered self-expandable metal stents (PCSEMSs) in this setting. DESIGN:Prospective, multicenter, uncontrolled study. SETTING:Three French academic hospit...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章,多中心研究
doi：10.1016/j.gie.2010.08.016
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Despite a paucity of women occupying leadership positions in academic medicine, studies have shown a higher ratio of female representation in the program director position compared with division chief in multiple specialties. This study aims to determine whether this trend exists in 3-year gastroent...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2017.01.019
更新日期：2017-10-01 00:00:00
abstract：:Endoscopic hemostatic therapies have become increasingly popular and appear capable of controlling hemorrhage from peptic ulcers and reducing the need for surgery, but many physicians are unsure that the efficacy justifies the cost. In order to study this clinically and economically important issue, we developed a mat...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(87)71598-3
更新日期：1987-08-01 00:00:00
abstract：BACKGROUND:Endoscopic ultrasound (EUS) was used to evaluate cirrhotic patients with and without prior variceal hemorrhage. The findings were compared with those of EUS in noncirrhotic control subjects to determine EUS features indicative of cirrhosis and of a risk for variceal hemorrhage. METHODS:Patients with cirrhos...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1067/mge.2000.107297
更新日期：2000-10-01 00:00:00
