Endoscopic magnet placement into subadventitial tunnels for augmenting the lower esophageal sphincter using submucosal endoscopy: ex vivo and in vivo study in a porcine model (with video).


BACKGROUND AND AIMS:Endolumenal therapies serve as a treatment option for GERD. This study aimed to determine if magnets could be placed endoscopically using the adventitial layer to create a subadventitial space near the esophagogastric junction to augment the lower esophageal sphincter using submucosal endoscopy. METHODS:This study consisted of 2 phases, ex vivo and in vivo, with domestic pig esophagus. A long submucosal tunnel was made at the mid to lower esophagus. The muscularis propria was incised by a needle-knife within the submucosal tunnel. A subadventitial tunnel was made by biliary balloon catheter blunt dissection, and a magnet was deployed in the subadventitial space. The same maneuver was done within the opposing esophageal wall, with magnet placement in the opposing subadventitial space. RESULTS:Submucosal tunnels and subadventitial tunnels were successful without perforation ex vivo in all attempts and in 9 of 10 cases, respectively. Magnets were deployed in the subadventitial space in 7 cases. Magnets connected and separated with atraumatic endoscope passage into the stomach and reconnected when the endoscope was withdrawn under fluoroscopy in 5 of 7 cases (71.4%). In vivo submucosal tunnels and subadventitial tunnels were successful in all 5 cases, and magnet augmentation was functionally active in 4 cases (80%). CONCLUSION:Subadventitial tunnels were feasible and could represent a new working space for endoscopic treatment. Endoscopic placement of magnets within the subadventitial space may be an attractive alternative endolumenal therapy for GERD.


Gastrointest Endosc


Dobashi A,Wu SW,Deters JL,Miller CA,Knipschield MA,Cameron GP,Lu L,Rajan E,Gostout CJ




Has Abstract


2019-02-01 00:00:00














  • Endoscopic submucosal dissection with suturing for the treatment of weight regain after gastric bypass: outcomes and comparison with traditional transoral outlet reduction (with video).

    abstract:BACKGROUND AND AIMS:Although traditional transoral outlet reduction (TORe) involves argon plasma coagulation (APC) before endoscopic suturing, modified endoscopic submucosal dissection (ESD) has also been used. This study aims to evaluate the safety and efficacy of modified ESD-TORe in comparison with traditional APC-T...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Jirapinyo P,de Moura DTH,Thompson CC

    更新日期:2020-06-01 00:00:00

  • Adenoma recurrence after piecemeal colonic EMR is predictable: the Sydney EMR recurrence tool.

    abstract:BACKGROUND AND AIMS:EMR is the primary treatment of large laterally spreading lesions (LSLs) in the colon. Residual or recurrent adenoma (RRA) is a major limitation. We aimed to identify a robust method to stratify the risk of RRA. METHODS:Prospective multicenter data on consecutive LSLs ≥20 mm removed by piecemeal EM...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Tate DJ,Desomer L,Klein A,Brown G,Hourigan LF,Lee EY,Moss A,Ormonde D,Raftopoulos S,Singh R,Williams SJ,Zanati S,Byth K,Bourke MJ

    更新日期:2017-03-01 00:00:00

  • Predictors of stricture formation after photodynamic therapy for high-grade dysplasia in Barrett's esophagus.

    abstract:BACKGROUND:Stricture formation is the leading cause of long-term morbidity after photodynamic therapy (PDT). Risk factors for stricture formation have not been studied. OBJECTIVE:To assess risk factors for stricture formation in patients undergoing PDT for Barrett's esophagus with high-grade dysplasia (HGD). DESIGN:R...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Prasad GA,Wang KK,Buttar NS,Wongkeesong LM,Lutzke LS,Borkenhagen LS

    更新日期:2007-01-01 00:00:00

  • Laparoscopic-assisted double-balloon enteroscopy for small-bowel polyp surveillance and treatment in patients with Peutz-Jeghers syndrome.

    abstract:BACKGROUND:Surveillance and treatment of small-bowel polyps in patients with Peutz-Jeghers syndrome (PJS) can be challenging and may require intraoperative enteroscopy. While initial reports that used double-balloon enteroscopy (DBE) for the resection of small-bowel polyps in patients with PJS appear promising, complet...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Ross AS,Dye C,Prachand VN

    更新日期:2006-12-01 00:00:00

  • Endoscopic submucosal dissection by using a grasping-type scissors forceps: a preliminary clinical study (with video).

    abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate. The shortcoming of this method is the difficulty of fixing the knife to the target lesion. It can lead to an unexpected incision and result in major complications, such as perfor...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章


    authors: Akahoshi K,Honda K,Akahane H,Akiba H,Matsui N,Motomura Y,Kubokawa M,Endo S,Higuchi N,Oya M

    更新日期:2008-06-01 00:00:00

  • The Optical Dilator: a clear, over-the-scope bougie with sequential dilating segments.

    abstract:PURPOSE:The safety and efficacy of esophageal dilation is enhanced when direct visualization is possible, tactile sensation and feedback from resistance is maintained, and multiple dilations with a single passage of the dilating device is an option. The InScope Optical Dilator (InScope, a Division of Ethicon Endo-Surge...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Jones MP,Bratten JR,McClave SA

    更新日期:2006-05-01 00:00:00

  • Success and complications of endoscopic removal of giant duodenal and ampullary polyps: a comparative series.

    abstract:BACKGROUND:Increasing reports suggest that endoscopic removal of benign ampullary and duodenal polyps is safe and frequently definitive; however, most reported polyps have been small in size (<3 cm). We have developed experience with endoscopic removal of increasingly large and complex polyps. PATIENTS:Fifty-one cases...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Eswaran SL,Sanders M,Bernadino KP,Ansari A,Lawrence C,Stefan A,Mattia A,Howell DA

    更新日期:2006-12-01 00:00:00

  • Antegrade and retrograde endoscopic approach in the establishment of a neo-esophagus: a novel technique.

    abstract:BACKGROUND:Although total obstruction or secondary atresia of the esophagus is extremely rare, high-grade strictures are not uncommon. The retrograde approach was previously described to achieve dilation when the conventional antegrade method fails. SETTING:Gastroenterology laboratory in a tertiary referral center. P...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Al-Haddad M,Pungpapong S,Wallace MB,Raimondo M,Woodward TA

    更新日期:2007-02-01 00:00:00

  • Prevalence of adenomas and advanced adenomas in patients in the 40- to 49-year age group undergoing screening colonoscopy because of a family history of adenoma/polyp in a first-degree relative.

    abstract:BACKGROUND:Per current guidelines, patients with a first-degree relative (FDR) with adenomas should get screened at age 40. Data on the prevalence of adenomas and advanced adenomas (AAs) in these patients are lacking. OBJECTIVE:To examine the prevalence of adenomas and AAs in 40- to 49-year-old individuals undergoing ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Gupta A,Samadder J,Elliott E,Sethi S,Schoenfeld P

    更新日期:2012-04-01 00:00:00

  • Low symptomatic premature stent occlusion of multiple plastic stents for benign biliary strictures: comparing standard and prolonged stent change intervals.

    abstract:BACKGROUND:Benign biliary strictures are typically managed endoscopically whereby an increasing size or number of plastic stents is placed at ERCP. Stents are often changed every 3 to 4 months based on the known median patency of a single biliary stent, but patency data for multiple biliary stents are lacking. OBJECTI...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Lawrence C,Romagnuolo J,Payne KM,Hawes RH,Cotton PB

    更新日期:2010-09-01 00:00:00

  • Safety of endoscopic interventions in patients with thrombocytopenia.

    abstract:BACKGROUND:The risk of endoscopic interventions in thrombocytopenia has received little attention in the medical literature. OBJECTIVE:The aim of this study was to assess the safety of endoscopic interventions including evaluation of GI bleeding (GIB) in patients with thrombocytopenia. DESIGN AND SETTING:Retrospectiv...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Krishna SG,Rao BB,Thirumurthi S,Lee JH,Ramireddy S,Guindani M,Ross WA

    更新日期:2014-09-01 00:00:00

  • Endoscopic ablation of Barrett's esophagus: a multicenter study with 2.5-year follow-up.

    abstract:BACKGROUND:For patients with Barrett's esophagus (BE), life-long surveillance endoscopy is recommended because of an elevated risk for developing dysplasia and esophageal adenocarcinoma. Various endoscopic therapies have been used to eradicate BE. Recently circumferential radiofrequency ablation has been used with enco...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Fleischer DE,Overholt BF,Sharma VK,Reymunde A,Kimmey MB,Chuttani R,Chang KJ,Lightdale CJ,Santiago N,Pleskow DK,Dean PJ,Wang KK

    更新日期:2008-11-01 00:00:00

  • Endoscopic stenting in patients with recurrent malignant obstruction after gastric surgery: uncovered versus simultaneously deployed uncovered and covered (double) self-expandable metal stents.

    abstract:BACKGROUND:Uncovered, rather than covered, metal stents are commonly used for palliation of malignant gastric outlet obstruction because of the low risk of stent migration, but tumor ingrowth risk is a major drawback. Few reports address malignant obstruction after gastric surgery. OBJECTIVE:Our purpose was to compare...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Song GA,Kang DH,Kim TO,Heo J,Kim GH,Cho M,Heo JH,Kim JY,Lee JS,Jeoung YJ,Jeon TY,Kim DH,Sim MS

    更新日期:2007-05-01 00:00:00

  • Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD.

    abstract:BACKGROUND:Healing of mucosal lesions appears to offer significant benefit and is an important end point in clinical trials of treatment for Crohn's disease. The only validated endoscopic activity score at present is the Crohn's Disease Endoscopic Index of Severity, which is complicated and time consuming and, hence, i...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Daperno M,D'Haens G,Van Assche G,Baert F,Bulois P,Maunoury V,Sostegni R,Rocca R,Pera A,Gevers A,Mary JY,Colombel JF,Rutgeerts P

    更新日期:2004-10-01 00:00:00

  • Variations between endoscopists in rates of detection of colorectal neoplasia and their impact on a regional screening program based on colonoscopy after fecal occult blood testing.

    abstract:BACKGROUND:There are few data about the performance variability among endoscopists participating to nationwide or regionwide colorectal cancer screening programs. OBJECTIVE:To assess the variability of neoplasia detection rates among endoscopists participating in a regional colorectal cancer screening program based on...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Bretagne JF,Hamonic S,Piette C,Manfredi S,Leray E,Durand G,Riou F

    更新日期:2010-02-01 00:00:00

  • Intraductal balloon-guided direct peroral cholangioscopy with an ultraslim upper endoscope (with videos).

    abstract:BACKGROUND:Peroral cholangioscopy (POC) provides direct visualization of the bile duct and facilitates diagnostic procedures and therapeutic intervention. The currently available mother-baby endoscope system is not widely used because of several limitations. Although direct cholangioscopy with an ultraslim upper endosc...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Moon JH,Ko BM,Choi HJ,Hong SJ,Cheon YK,Cho YD,Lee JS,Lee MS,Shim CS

    更新日期:2009-08-01 00:00:00

  • Efficacy and safety of 1-step transnasal endoscopic nasobiliary drainage for the treatment of acute cholangitis in patients with previous endoscopic sphincterotomy (with videos).

    abstract:BACKGROUND:Endoscopic nasobiliary drainage (NBD) for the treatment of acute cholangitis is an accepted method. A recently developed ultrathin transnasal videoendoscope is minimally invasive, even for patients who are critically ill. OBJECTIVE:To evaluate the clinical efficacy and safety of 1-step NBD by transnasal vid...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Itoi T,Kawai T,Sofuni A,Itokawa F,Tsuchiya T,Kurihara T,Kusano C,Saito Y,Gotoda T

    更新日期:2008-07-01 00:00:00

  • Efficacy of endoscopic preventive procedures to reduce delayed adverse events after endoscopic resection of superficial nonampullary duodenal epithelial tumors: a meta-analysis of observational comparative trials.

    abstract:BACKGROUND AND AIMS:Although various procedures have been used to prevent serious adverse events after endoscopic resection of the duodenum, their effectiveness has not been determined. In this study, we conducted a systematic review and meta-analysis to determine whether endoscopic preventive procedures reduce delayed...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,评审


    authors: Tsutsumi K,Kato M,Kakushima N,Iguchi M,Yamamoto Y,Kanetaka K,Uraoka T,Fujishiro M,Sho M,Japan Duodenal Cancer Guideline Committee.

    更新日期:2021-02-01 00:00:00

  • A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding.

    abstract:BACKGROUND:Although the early use of a risk stratification score in upper GI bleeding is recommended, existing risk scores are not widely used in clinical practice. OBJECTIVE:We sought to develop and validate an easily calculated bedside risk score, AIMS65, by using data routinely available at initial evaluation. DES...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,多中心研究


    authors: Saltzman JR,Tabak YP,Hyett BH,Sun X,Travis AC,Johannes RS

    更新日期:2011-12-01 00:00:00

  • Endoscopic management of duodenal adenomas in patients with familial adenomatous polyposis.

    abstract:BACKGROUND AND AIMS:Almost all patients with familial adenomatous polyposis (FAP) develop duodenal adenomas, with a 4% to 18% risk of progression into duodenal cancer. Prophylactic endoscopic resection of duodenal adenomas may prevent cancer and is considered safer than surgical alternatives; however, data are limited....

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Roos VH,Bastiaansen BA,Kallenberg FGJ,Aelvoet AS,Bossuyt PMM,Fockens P,Dekker E

    更新日期:2021-02-01 00:00:00

  • Endoscopic myotomy in the treatment of achalasia.

    abstract::Seventeen patients with achalasia were treated by endoscopic myotomy limited to the esophageal rosette and avoiding the distal antireflux zone. Clinical, radiological, endoscopic, and manometric follow-up revealed improvement comparable to that seen in patients after successful surgical myotomy or pneumatic dilation. ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Ortega JA,Madureri V,Perez L

    更新日期:1980-02-01 00:00:00

  • Forceful balloon dilation: an outpatient procedure for achalasia.

    abstract::The initial treatment of choice in patients with achalasia is balloon dilation. Heretofore, this procedure was performed on an in-hospital basis resulting in high patient cost. This study evaluated the safety and efficacy of pneumatic dilation as an outpatient procedure. Sixty-one procedures were performed on 50 patie...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Barkin JS,Guelrud M,Reiner DK,Goldberg RI,Phillips RS

    更新日期:1990-03-01 00:00:00

  • Long-term outcomes of a newly developed hybrid metal stent for EUS-guided biliary drainage (with videos).

    abstract:BACKGROUND AND AIMS:Although fully covered self-expandable metal stents (FCSEMSs) have been commonly used for EUS-guided biliary drainage (EUS-BD), FCSEMS migration is a main limitation of this procedure. In the present study we evaluated the technical and clinical success rates, adverse events, and long-term outcomes ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Cho DH,Lee SS,Oh D,Song TJ,Park DH,Seo DW,Lee SK,Kim MH

    更新日期:2017-05-01 00:00:00

  • EUS-guided FNA diagnostic yield of malignancy in solid pancreatic masses: a benchmark for quality performance measurement.

    abstract:BACKGROUND:The diagnostic yield of EUS-guided FNA (EUS-FNA) of solid pancreatic masses is a potential benchmark for EUS-FNA quality, because the majority of EUS-FNA of solid pancreatic masses should be diagnostic for malignancy. OBJECTIVES:To determine the cytologic diagnostic rate of malignancy in EUS-FNA of solid pa...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,多中心研究


    authors: Savides TJ,Donohue M,Hunt G,Al-Haddad M,Aslanian H,Ben-Menachem T,Chen VK,Coyle W,Deutsch J,DeWitt J,Dhawan M,Eckardt A,Eloubeidi M,Esker A,Gordon SR,Gress F,Ikenberry S,Joyce AM,Klapman J,Lo S,Maluf-Filho F,Nic

    更新日期:2007-08-01 00:00:00

  • Preoperative indicators of failure of en bloc resection or perforation in colorectal endoscopic submucosal dissection: implications for lesion stratification by technical difficulties during stepwise training.

    abstract:BACKGROUND AND AIMS:The technical difficulties inherent in endoscopic submucosal dissection (ESD) for colorectal neoplasms may result in the failure of en bloc resection or perforation. The aim of this retrospective study was to assess the predictors of en bloc resection failure or perforation by using preoperatively a...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Imai K,Hotta K,Yamaguchi Y,Kakushima N,Tanaka M,Takizawa K,Kawata N,Matsubayashi H,Shimoda T,Mori K,Ono H

    更新日期:2016-05-01 00:00:00

  • Extended endoscopic mucosal resection does not reduce recurrence compared with standard endoscopic mucosal resection of large laterally spreading colorectal lesions.

    abstract:BACKGROUND AND AIMS:Effective interventions to prevent residual and/or recurrent adenoma (RRA) after EMR of large sessile and laterally spreading colorectal lesions (LSL) are yet to be determined. RRA may occur due to inconspicuous adenoma at the EMR margin. We aimed to determine the efficacy and safety of extended EMR...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,多中心研究


    authors: Bahin FF,Pellise M,Williams SJ,Bourke MJ

    更新日期:2016-12-01 00:00:00

  • Integrated diagnostic strategy for the invasion depth of early gastric cancer by conventional endoscopy and EUS.

    abstract:BACKGROUND:Although conventional endoscopy (CE) and EUS are considered useful for predicting the invasion depth (T-staging) in early gastric cancer (EGC), no effective diagnostic strategy has been established. OBJECTIVE:To produce simple CE criteria and to elucidate an efficient diagnostic method by combining CE and E...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Tsujii Y,Kato M,Inoue T,Yoshii S,Nagai K,Fujinaga T,Maekawa A,Hayashi Y,Akasaka T,Shinzaki S,Watabe K,Nishida T,Iijima H,Tsujii M,Takehara T

    更新日期:2015-09-01 00:00:00

  • Validity of the Rockall scoring system after endoscopic therapy for bleeding peptic ulcer: a prospective cohort study.

    abstract:BACKGROUND:The Rockall scoring system was developed in unselected patients, the majority of whom did not receive endoscopic therapy. The aim of this study was to assess the validity of the Rockall system in high-risk patients who undergo endoscopic therapy for peptic ulcer hemorrhage. METHODS:Rockall scores were calcu...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,随机对照试验


    authors: Church NI,Dallal HJ,Masson J,Mowat NA,Johnston DA,Radin E,Turner M,Fullarton G,Prescott RJ,Palmer KR

    更新日期:2006-04-01 00:00:00

  • Brush cytology evaluation of lesions encountered during ERCP.

    abstract::Malignant obstruction of the pancreaticobiliary system is a frequent indication for ERCP. Twenty-five patients with abnormalities suggestive of malignancy were encountered during ERCP at our institution and brush cytology was obtained. Positive cytology specimens were collected in 12 of 20 (60%) cases of malignancy ca...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Scudera PL,Koizumi J,Jacobson IM

    更新日期:1990-05-01 00:00:00

  • Quantitation of colonic injury from argon laser, neodymium: YAG laser and monopolar electrocautery applied to flat mucosa and small sessile polyps of the canine colon.

    abstract::This study determined the optimum laser energy for ablation of colonic mucosal lesions and small sessile polyps in the canine colon. Neodymium (Nd):YAG laser, argon laser, and monopolar electrocautery were applied to exposed canine colonic mucosa for various application times at various power settings. At the minimum ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Hunter JG,Burt RW,Becker JM,Lee RG,Dixon JA

    更新日期:1989-01-01 00:00:00