Endoscopic magnet placement into subadventitial tunnels for augmenting the lower esophageal sphincter using submucosal endoscopy: ex vivo and in vivo study in a porcine model (with video).


BACKGROUND AND AIMS:Endolumenal therapies serve as a treatment option for GERD. This study aimed to determine if magnets could be placed endoscopically using the adventitial layer to create a subadventitial space near the esophagogastric junction to augment the lower esophageal sphincter using submucosal endoscopy. METHODS:This study consisted of 2 phases, ex vivo and in vivo, with domestic pig esophagus. A long submucosal tunnel was made at the mid to lower esophagus. The muscularis propria was incised by a needle-knife within the submucosal tunnel. A subadventitial tunnel was made by biliary balloon catheter blunt dissection, and a magnet was deployed in the subadventitial space. The same maneuver was done within the opposing esophageal wall, with magnet placement in the opposing subadventitial space. RESULTS:Submucosal tunnels and subadventitial tunnels were successful without perforation ex vivo in all attempts and in 9 of 10 cases, respectively. Magnets were deployed in the subadventitial space in 7 cases. Magnets connected and separated with atraumatic endoscope passage into the stomach and reconnected when the endoscope was withdrawn under fluoroscopy in 5 of 7 cases (71.4%). In vivo submucosal tunnels and subadventitial tunnels were successful in all 5 cases, and magnet augmentation was functionally active in 4 cases (80%). CONCLUSION:Subadventitial tunnels were feasible and could represent a new working space for endoscopic treatment. Endoscopic placement of magnets within the subadventitial space may be an attractive alternative endolumenal therapy for GERD.


Gastrointest Endosc


Dobashi A,Wu SW,Deters JL,Miller CA,Knipschield MA,Cameron GP,Lu L,Rajan E,Gostout CJ




Has Abstract


2019-02-01 00:00:00














  • Early colonoscopy for acute lower GI bleeding predicts shorter hospital stay: a retrospective study of experience in a single center.

    abstract:BACKGROUND:Appropriate management of lower-GI hemorrhage remains controversial largely because outcomes data are lacking. It is our hypothesis that clinical factors, such as comorbidity, hemodynamic instability, and timing of colonoscopy, are associated with hospital lengths of stay. METHODS:Medical records of patient...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Schmulewitz N,Fisher DA,Rockey DC

    更新日期:2003-12-01 00:00:00

  • Automatic detection and classification of protruding lesions in wireless capsule endoscopy images based on a deep convolutional neural network.

    abstract:BACKGROUND AND AIMS:Protruding lesions of the small bowel vary in wireless capsule endoscopy (WCE) images, and their automatic detection may be difficult. We aimed to develop and test a deep learning-based system to automatically detect protruding lesions of various types in WCE images. METHODS:We trained a deep convo...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Saito H,Aoki T,Aoyama K,Kato Y,Tsuboi A,Yamada A,Fujishiro M,Oka S,Ishihara S,Matsuda T,Nakahori M,Tanaka S,Koike K,Tada T

    更新日期:2020-07-01 00:00:00

  • Adverse events after surgery for nonmalignant colon polyps are common and associated with increased length of stay and costs.

    abstract:BACKGROUND AND AIMS:Endoscopic resection (ER) is a safe and effective treatment for nonmalignant complex colorectal polyps (complex polyps). Surgical resection (SR) remains prevalent despite limited outcomes data. We aimed to evaluate SR outcomes for complex polyps and compare SR outcomes to those of ER. METHODS:We pe...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Keswani RN,Law R,Ciolino JD,Lo AA,Gluskin AB,Bentrem DJ,Komanduri S,Pacheco JA,Grande D,Thompson WK

    更新日期:2016-08-01 00:00:00

  • EUS-guided confocal laser endomicroscopy: prediction of dysplasia in intraductal papillary mucinous neoplasms (with video).

    abstract:BACKGROUND AND AIMS:Previous studies have validated EUS-guided needle-based confocal laser endomicroscopy (nCLE) diagnosis of intraductal papillary mucinous neoplasms (IPMNs). We sought to derive EUS-guided nCLE criteria for differentiating IPMNs with high-grade dysplasia/adenocarcinoma (HGD-Ca) from those with low/int...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Krishna SG,Hart PA,DeWitt JM,DiMaio CJ,Kongkam P,Napoleon B,Othman MO,Yew Tan DM,Strobel SG,Stanich PP,Patel A,Luthra AK,Chan MQ,Blaszczak AM,Lee D,El-Dika S,McCarthy ST,Walker JP,Arnold CA,Porter K,Conwell DL

    更新日期:2020-03-01 00:00:00

  • Endoscopic balloon dilation of colonic and ileo-colonic Crohn's strictures: long-term results.

    abstract::The long-term effects of endoscopic dilation of colonic or ileo-colonic Crohn's disease strictures were analyzed. In 18 patients with a Crohn's disease-related low gastrointestinal stricture, the stenosis was dilated using through-the-scope (TTS) balloon catheters. A dilation to a diameter of 18 mm was always attempte...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Breysem Y,Janssens JF,Coremans G,Vantrappen G,Hendrickx G,Rutgeerts P

    更新日期:1992-03-01 00:00:00

  • WITHDRAWN: Endoscopic intervention for acute appendicitis: retrospective study of 101 cases.

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 撤回出版物


    authors: Chen Y,Wang M,Chen H,Zhao L,Liu L,Wang X,Huang J,Fan Z

    更新日期:2019-06-19 00:00:00

  • Endosonography of gastroesophageal varices: evaluation and follow-up of 76 cases.

    abstract::Endosonography was performed in 76 patients who had endoscopically detected gastroesophageal varices or questionable submucosal lesions, or who were being evaluated for pancreatic carcinoma or pancreatitis. The result were compared with surgery or autopsy results. The patients were divided retrospectively into four gr...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Tio TL,Kimmings N,Rauws E,Jansen P,Tytgat G

    更新日期:1995-08-01 00:00:00

  • Endoscopic ultrasonography in the differential diagnosis of pancreatic disease.

    abstract::Endoscopic ultrasonography was performed in 25 patients with suspected pancreatic disease. Cancer of the pancreas was recognized in 9 of 10 cases with 1 false negative and 2 false positive diagnoses. Chronic pancreatitis was recognized in 89% of cases. Technical difficulties limited the success of the examination in 2...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Kaufman AR,Sivak MV Jr

    更新日期:1989-05-01 00:00:00

  • Safety and usefulness of percutaneous transhepatic cholecystoscopy examination in high-risk surgical patients with acute cholecystitis.

    abstract:BACKGROUND:The aim of the present study was to evaluate the diagnostic and therapeutic usefulness of percutaneous transhepatic cholecystoscopy in high-risk surgical patients with acute cholecystitis. METHODS:Between January 1992 and June 1998, there were 33 consecutive patients who underwent percutaneous transhepatic ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章


    authors: Kim HJ,Lee SK,Kim MH,Yoo KS,Lim BC,Seo DW,Min YI

    更新日期:2000-11-01 00:00:00

  • Appendiceal orifice inflammation as a skip lesion in ulcerative colitis: an analysis in relation to medical therapy and disease extent.

    abstract:BACKGROUND:Although several reports have claimed that the appendix can be involved as a skip lesion in ulcerative colitis, they do not exclude the possibility that this skip lesion occurs as a result of medical therapy. Also, little is known about the relation between the presence of appendiceal orifice inflammation an...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章


    authors: Yang SK,Jung HY,Kang GH,Kim YM,Myung SJ,Shim KN,Hong WS,Min YI

    更新日期:1999-06-01 00:00:00

  • High pharyngoesophageal strictures after laryngopharyngectomy can also be treated by self-expandable plastic stents.

    abstract:BACKGROUND:Permanent dysphagia occurring after laryngectomy or laryngopharyngectomy can usually be treated by periodic dilation. Occasionally, however, conservative treatment is insufficient, and patients require long-term tube feeding. We describe 4 cases with stricture after laryngopharyngectomy who underwent inserti...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Somani SK,Verma N,Avasthi G,Ghosh A,Goyal R,Joshi N

    更新日期:2010-06-01 00:00:00

  • Systemic absorption of epinephrine after endoscopic submucosal injection in patients with bleeding peptic ulcers.

    abstract::Epinephrine injection is an effective, simple, and economical method of endoscopic hemostasis for bleeding peptic ulcers. We measured catecholamine levels in 18 patients with actively bleeding ulcers (8 gastric ulcers and 10 duodenal ulcers) treated by endoscopic injection. Injection of epinephrine (1:10,000 IU) was g...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Sung JY,Chung SC,Low JM,Cocks R,Ip SM,Tan P,Leung JW,Li AK,Oh TE

    更新日期:1993-01-01 00:00:00

  • Preoperative assessment of extrahepatic bile duct carcinoma using three-dimensional intraductal US.

    abstract:BACKGROUND:We investigated the utility of a new imaging modality, three-dimensional intraductal ultrasonography (US), for staging bile duct cancer. METHODS:In eight patients with extrahepatic bile duct carcinoma, two- and three-dimensional intraductal US was used to assess tumor invasion of the right hepatic artery, p...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Tamada K,Tomiyama T,Ohashi A,Wada S,Satoh Y,Miyata T,Ido K,Sugano K

    更新日期:1999-10-01 00:00:00

  • Laparoscopy for pre-operative staging and assessment of operability in gastric carcinoma.

    abstract::Laparoscopy was performed in 40 patients with gastric carcinoma, whose lesions were otherwise considered amenable to operation, in order to more accurately stage the disease and ascertain the prospect of resectability. Laparoscopy disclosed hitherto unrecognized distant metastases in 5 cases (12.5%) and locally advanc...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Kriplani AK,Kapur BM

    更新日期:1991-07-01 00:00:00

  • EUS-guided portal injection chemotherapy for treatment of hepatic metastases: feasibility in the acute porcine model.

    abstract:BACKGROUND AND AIMS:Direct injection of chemotherapy into the portal vein for treatment of liver metastases may increase hepatic tissue levels while decreasing systemic levels and toxicities. We aimed to evaluate EUS-guided portal injection chemotherapy (EPIC) by using drug-eluting microbeads or nanoparticles and compa...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Faigel DO,Lake DF,Landreth TL,Kelman CC,Marler RJ

    更新日期:2016-02-01 00:00:00

  • Large-caliber metal stents versus plastic stents for the management of pancreatic walled-off necrosis.

    abstract:BACKGROUND AND AIMS:Symptomatic pancreatic walled-off necrosis (WON) may be managed by endoscopic transmural drainage and endoscopic transmural necrosectomy, with stent placement at endoscopic drainage sites. The optimal stent choice is yet to be determined. We compared outcomes after endoscopic management of WON using...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Abu Dayyeh BK,Mukewar S,Majumder S,Zaghlol R,Vargas Valls EJ,Bazerbachi F,Levy MJ,Baron TH,Gostout CJ,Petersen BT,Martin J,Gleeson FC,Pearson RK,Chari ST,Vege SS,Topazian MD

    更新日期:2018-01-01 00:00:00

  • Acute GI bleeding in the setting of supratherapeutic international normalized ratio in patients taking warfarin: endoscopic diagnosis, clinical management, and outcomes.

    abstract:BACKGROUND:Acute GI bleeding is a life-threatening complication of warfarin therapy. Acute GI bleeding in patients with an international normalized ratio of 4.0 or greater (supratherapeutic) is often attributed to trivial mucosal lesions. The aim of the study was to determine the frequency of potentially significant le...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Rubin TA,Murdoch M,Nelson DB

    更新日期:2003-09-01 00:00:00

  • Impact of direct-acting oral anticoagulants and warfarin on postendoscopic GI bleeding and thromboembolic events in patients undergoing elective endoscopy.

    abstract:BACKGROUND AND AIMS:An increasing number of patients are undergoing GI endoscopic procedures with active prescriptions for direct oral anticoagulants (DOACs). DOACs have been associated with a higher risk of GI bleeding (GIB) compared with warfarin. Our aims were to compare the risk of postendoscopic GIB and thromboemb...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Tien A,Kwok K,Dong E,Wu B,Chung J,Chang J,Reynolds K

    更新日期:2020-08-01 00:00:00

  • Intraductal US-directed management of bile duct stones without radiocontrast cholangiography.

    abstract:BACKGROUND/AIMS:Intraductal US (IDUS) is an examination of the bile duct by using a thin-caliber ultrasonic probe, yielding real-time, high-quality cross-sectional images. We prospectively evaluated the feasibility and safety of IDUS-directed stone removal without radiocontrast cholangiography (RC) in naïve patients wi...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Park SY,Park CH,Lim SU,Cho EA,Lee DH,Jun CH,Kim HS,Choi SK,Rew JS

    更新日期:2015-11-01 00:00:00

  • Asymptomatic pancreatic cystic neoplasm: a cost-effectiveness analysis of different strategies of management.

    abstract:BACKGROUND:Optimal management of asymptomatic pancreatic cystic neoplasm is not known. OBJECTIVE:In a decision analysis, the cost-effectiveness of different strategies for managing solitary, asymptomatic pancreatic cystic neoplasm were compared. INTERVENTION:Three strategies were examined in a Markov model with a thi...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Das A,Ngamruengphong S,Nagendra S,Chak A

    更新日期:2009-10-01 00:00:00

  • Comparison of quality of life and worry of cancer recurrence between endoscopic and surgical treatment for early gastric cancer.

    abstract:BACKGROUND:The quality of life (QOL) of patients who survive early gastric cancer (EGC) is an area of increasing interest. OBJECTIVE:To compare the QOL and degree of worry of cancer recurrence in EGC patients who underwent endoscopic submucosal dissection (ESD) or surgery. DESIGN:Cross-sectional study. SETTINGS:A te...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Choi JH,Kim ES,Lee YJ,Cho KB,Park KS,Jang BK,Chung WJ,Hwang JS,Ryu SW

    更新日期:2015-08-01 00:00:00

  • Brush cytology evaluation of lesions encountered during ERCP.

    abstract::Malignant obstruction of the pancreaticobiliary system is a frequent indication for ERCP. Twenty-five patients with abnormalities suggestive of malignancy were encountered during ERCP at our institution and brush cytology was obtained. Positive cytology specimens were collected in 12 of 20 (60%) cases of malignancy ca...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Scudera PL,Koizumi J,Jacobson IM

    更新日期:1990-05-01 00:00:00

  • Abdominal compression during endoscopy (the Bolster technique) demonstrates hidden Schatzki rings (with videos).

    abstract:BACKGROUND AND AIMS:Schatzki rings are found in the distal esophagus, are associated with hiatal hernias, and present with intermittent dysphagia to solid foods. They can be identified by radiology (GI series or barium swallow studies) or endoscopy. Rings are not always visualized during endoscopy in patients in whom t...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Jouhourian C,Bonis PA,Guelrud M

    更新日期:2016-05-01 00:00:00

  • Optimizing histopathologic evaluation of EMR specimens of Barrett's esophagus-related neoplasia: a randomized study of 3 specimen handling methods.

    abstract:BACKGROUND AND AIMS:Endoscopic resection is the cornerstone of treatment of Barrett's esophagus (BE)-related neoplasia. However, accurate histopathologic evaluation of endoscopic resection specimens can be challenging, and the preferred specimen handling method remains unknown. Therefore, the aim of our study was to co...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,随机对照试验


    authors: Overwater A,van der Meulen KE,Künzli HT,Schoon EJ,Bergman JJGHM,Mihaela Raicu G,Seldenrijk KCA,Weusten BLAM

    更新日期:2019-09-01 00:00:00

  • Endotherapy versus surgery for early neoplasia in Barrett's esophagus: a meta-analysis.

    abstract:BACKGROUND:Esophagectomy is the conventional treatment for Barrett's esophagus with high-grade dysplasia and intramucosal cancer. Endotherapy is an alternative treatment. OBJECTIVE:To compare the efficacy and safety of these 2 treatments. DESIGN:PubMed, Web of Science, EMBASE, Cochrane Library and momentous meeting a...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,meta分析,评审


    authors: Wu J,Pan YM,Wang TT,Gao DJ,Hu B

    更新日期:2014-02-01 00:00:00

  • Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience.

    abstract:BACKGROUND:The importance of sedation during endoscopy is well established. There is no consensus about the best techniques for sedation, which specialist should perform it, and in which location. OBJECTIVE:To provide data on the epidemiology of adverse events during sedation for endoscopy. DESIGN:Retrospective analy...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Agostoni M,Fanti L,Gemma M,Pasculli N,Beretta L,Testoni PA

    更新日期:2011-08-01 00:00:00

  • Decision analysis of prophylactic treatment for patients with high-risk esophageal varices.

    abstract:BACKGROUND:Clinical decision analyses were conducted to quantify the uncertainty and to identify important factors in selection of prophylactic therapy for patients with esophageal varices. METHODS:A Markov model compared variceal ligation, beta-blockers, and "watchful waiting" strategies in terms of bleeding-free lif...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Aoki N,Kajiyama T,Beck JR,Cone RW,Soma K,Fukui T

    更新日期:2000-12-01 00:00:00

  • ERCP guide wires.

    abstract::Guide wires have become an essential part of therapeutic biliary and pancreatic endoscopy. The Teflon-painted stainless steel wire still remains the standard guide wire. However, special situations call for the use of some of the more specialized guide wires mentioned in this article. The endoscopist needs to be famil...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,评审


    authors: Jacob L,Geenen JE

    更新日期:1996-01-01 00:00:00

  • Integrated diagnostic strategy for the invasion depth of early gastric cancer by conventional endoscopy and EUS.

    abstract:BACKGROUND:Although conventional endoscopy (CE) and EUS are considered useful for predicting the invasion depth (T-staging) in early gastric cancer (EGC), no effective diagnostic strategy has been established. OBJECTIVE:To produce simple CE criteria and to elucidate an efficient diagnostic method by combining CE and E...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Tsujii Y,Kato M,Inoue T,Yoshii S,Nagai K,Fujinaga T,Maekawa A,Hayashi Y,Akasaka T,Shinzaki S,Watabe K,Nishida T,Iijima H,Tsujii M,Takehara T

    更新日期:2015-09-01 00:00:00

  • Snare cautery debridement prior to Nd:YAG photoablation improves treatment efficiency of broad-based adenomas of the colorectum.

    abstract::Forty-six patients who underwent piecemeal resection of large, sessile villous adenomas followed by immediate laser photoablative therapy are presented. In contrast to previously published series utilizing laser alone, prior snare resection of such lesions provides copious tissue for histologic analysis, decreases the...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


    authors: Low DE,Kozarek RA

    更新日期:1989-07-01 00:00:00