Flumazenil used for reversal of midazolam-induced sedation in endoscopy outpatients.

Abstract:

:A double-blind, placebo-controlled randomized clinical study was performed in 69 outpatients scheduled for endoscopy and sedated with midazolam to assess the efficacy, safety, and usefulness of flumazenil in reversing the effects of midazolam-induced sedation. Midazolam was administered intravenously before endoscopy up to a maximum dose of 15 mg. After endoscopy either flumazenil or placebo was injected. Vital signs and psychomotoric tests were assessed before injection of midazolam, before injection of flumazenil or placebo, and 5, 15, 30, 60, 240, and 360 min afterward. Thirty-six patients received flumazenil, 33 placebo. All parameters returned to pre-sedation levels within 5 min in all patients in the flumazenil group, with significant differences as compared with placebo after 5, 15, 30, and 60 min. Flumazenil was well tolerated. No rebound sedation was observed. Flumazenil is a safe and effective benzodiazepine antagonist. The combination of midazolam with flumazenil makes it possible to reduce the recovery period and is useful in outpatient endoscopy.

journal_name

Gastrointest Endosc

authors

Bartelsman JF,Sars PR,Tytgat GN

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

S9-12

issue

3 Suppl

eissn

0016-5107

issn

1097-6779

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.1016/j.gie.2008.07.041

    authors: Ha CY,Shah R,Chen J,Azar RR,Edmundowicz SA,Early DS

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    doi:10.1016/j.gie.2010.11.053

    authors: Choi J,Kim SG,Im JP,Kim JS,Jung HC,Song IS

    更新日期:2011-05-01 00:00:00

  • Quality of colonoscopy withdrawal technique and variability in adenoma detection rates (with videos).

    abstract:BACKGROUND:Studies suggest that endoscopist-related factors such as colonoscopy withdrawal time are important in determining the adenoma detection rate (ADR). OBJECTIVE:To determine the importance of withdrawal technique in differentiating among endoscopists with varying ADRs. DESIGN:Prospective, multicenter study. ...

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    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.gie.2011.03.003

    authors: Lee RH,Tang RS,Muthusamy VR,Ho SB,Shah NK,Wetzel L,Bain AS,Mackintosh EE,Paek AM,Crissien AM,Saraf LJ,Kalmaz DM,Savides TJ

    更新日期:2011-07-01 00:00:00

  • Evaluation of a voice recognition system for generation of therapeutic ERCP reports.

    abstract::We evaluated a computerized report-generating system using voice recognition technology (EndoSpeak) for producing therapeutic ERCP reports. For 30 consecutive ERCP cases, reports using both EndoSpeak and standard dictation were generated at the end of the procedure. The cases were scored for overall difficulty and the...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(91)70866-3

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    更新日期:1991-11-01 00:00:00

  • A comparison of 2 distal attachment mucosal exposure devices: a noninferiority randomized controlled trial.

    abstract:BACKGROUND AND AIMS:Endocuff (Arc Medical Design, Leeds, UK) and Endocuff Vision (Arc Medical Design, Leeds, UK) are effective mucosal exposure devices for improving polyp detection during colonoscopy. AmplifEYE (Medivators Inc, Minneapolis, Minn, USA) is a device that appears similar to the Endocuff devices but has re...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2019.06.046

    authors: Rex DK,Sagi SV,Kessler WR,Rogers NA,Fischer M,Bohm ME,Dewitt JM,Lahr RE,Searight MP,Sullivan AW,McWhinney CD,Garcia JR,Broadley HM,Vemulapalli KC

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  • Endoscopic ultrasonography in the differential diagnosis of pancreatic disease.

    abstract::Endoscopic ultrasonography was performed in 25 patients with suspected pancreatic disease. Cancer of the pancreas was recognized in 9 of 10 cases with 1 false negative and 2 false positive diagnoses. Chronic pancreatitis was recognized in 89% of cases. Technical difficulties limited the success of the examination in 2...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(89)72761-9

    authors: Kaufman AR,Sivak MV Jr

    更新日期:1989-05-01 00:00:00

  • Recanalization of tube overgrowth: a useful new indication for laser in palliation of malignant dysphagia.

    abstract::Overgrowth of an esophageal prosthesis by cancer is a late complication of insertion which presents a difficult management problem. We have treated 14 such patients; 9 had Celestin tubes and 5 Atkinson tubes in situ for a median of 7 months. The median patient age was 75 years; 3 had squamous cell carcinomas and 11 ad...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(92)70383-6

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    更新日期:1992-03-01 00:00:00

  • Incidence of gastric cancer after endoscopic resection of gastric adenoma.

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    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2015.10.024

    authors: Yoon SB,Park JM,Lim CH,Kim JS,Cho YK,Lee BI,Lee IS,Kim SW,Choi MG

    更新日期:2016-06-01 00:00:00

  • Evaluation of a new curved linear array echoendoscopy system for EUS.

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    pub_type: 杂志文章

    doi:10.1016/s0016-5107(03)70038-8

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    更新日期:2003-06-01 00:00:00

  • Risk factors for post-ERCP pancreatitis in wire-guided cannulation for therapeutic biliary ERCP.

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    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2014.06.005

    authors: Nakai Y,Isayama H,Sasahira N,Kogure H,Sasaki T,Yamamoto N,Saito K,Umefune G,Akiyama D,Kawahata S,Matsukawa M,Saito T,Hamada T,Takahara N,Mizuno S,Miyabayashi K,Mohri D,Hirano K,Tada M,Koike K

    更新日期:2015-01-01 00:00:00

  • Endoscopic treatment with multiple stents for post-liver-transplantation nonanastomotic biliary strictures.

    abstract:BACKGROUND:Over the past decade, ERCP has become the preferred method of treatment for biliary strictures in patients after orthotopic liver transplantation (OLT). Although data strongly support ERCP for treating anastomotic strictures, the little information available for the role of ERCP in the treatment of nonanasto...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2008.09.057

    authors: Tabibian JH,Asham EH,Goldstein L,Han SH,Saab S,Tong MJ,Busuttil RW,Durazo FA

    更新日期:2009-06-01 00:00:00

  • Additive endoscopic resection may be sufficient for patients with a positive lateral margin after endoscopic resection of early gastric cancer.

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    pub_type: 杂志文章

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    authors: Kim HW,Kim JH,Park JC,Jeon MY,Lee YC,Lee SK,Shin SK,Chung HS,Noh SH,Kim JW,Choi SH,Park JJ,Youn YH,Park H

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    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(92)70421-0

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    更新日期:1992-05-01 00:00:00

  • EMR is superior to rectal suction biopsy for analysis of enteric ganglia in constipation and dysmotility.

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    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2017.08.037

    authors: Barshop K,Willingham FF,Brugge WR,Zukerberg LR,Kuo B

    更新日期:2018-03-01 00:00:00

  • Plastic or metal stents for malignant stricture of the common bile duct? Results of a randomized prospective study.

    abstract:BACKGROUND:The systematic use of metal stents to treat biliary obstruction is restricted by high cost compared with plastic stents. The aims of this study were to compare cost and efficacy of plastic stents and metal stents in the treatment of patients with malignant common bile duct strictures and to define factors th...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1067/mge.2003.66

    authors: Kaassis M,Boyer J,Dumas R,Ponchon T,Coumaros D,Delcenserie R,Canard JM,Fritsch J,Rey JF,Burtin P

    更新日期:2003-02-01 00:00:00

  • Propofol for endoscopic sedation: A protocol for safe and effective administration by the gastroenterologist.

    abstract:BACKGROUND:There is increasing interest in the use of propofol, an ultrashort-acting hypnotic agent, for sedation during endoscopic examinations. A protocol was developed for administration of propofol, combined with small doses of midazolam and meperidine, for endoscopic sedation under the direction of a gastroenterol...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(03)02010-8

    authors: Cohen LB,Dubovsky AN,Aisenberg J,Miller KM

    更新日期:2003-11-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1067/mge.2002.121336

    authors: Ahuja V,Garg PK,Kumar D,Goindi G,Tandon RK

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    pub_type: 杂志文章,多中心研究

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    更新日期:1998-03-01 00:00:00

  • Endoscopic resection of benign tumors of the duodenal papilla without and with intraductal growth.

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    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2005.04.053

    authors: Bohnacker S,Seitz U,Nguyen D,Thonke F,Seewald S,deWeerth A,Ponnudurai R,Omar S,Soehendra N

    更新日期:2005-10-01 00:00:00

  • Introducer method of percutaneous endoscopic cecostomy and antegrade continence enema by use of the Chait Trapdoor cecostomy catheter in patients with adult neurogenic bowel.

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    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2005.12.035

    authors: Uno Y

    更新日期:2006-04-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1016/s0016-5107(94)70254-3

    authors: Siegel JH,Cohen SA,Kasmin FE,Veerappan A

    更新日期:1994-09-01 00:00:00

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    abstract:BACKGROUND AND AIMS:Previous studies have validated EUS-guided needle-based confocal laser endomicroscopy (nCLE) diagnosis of intraductal papillary mucinous neoplasms (IPMNs). We sought to derive EUS-guided nCLE criteria for differentiating IPMNs with high-grade dysplasia/adenocarcinoma (HGD-Ca) from those with low/int...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2019.09.014

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    更新日期:2020-03-01 00:00:00

  • A prospective multicenter study using a new multiband mucosectomy device for endoscopic resection of early neoplasia in Barrett's esophagus.

    abstract:BACKGROUND AND AIMS:Early neoplasia in Barrett's esophagus (BE) can be effectively and safely removed by endoscopic resection (ER) using multiband mucosectomy (MBM). This study aimed to document performance of a novel MBM device designed for improved visualization, easier passage of accessories, and better suction powe...

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    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.gie.2018.06.030

    authors: Pouw RE,Beyna T,Belghazi K,Koch AD,Schoon EJ,Haidry R,Weusten BL,Bisschops R,Shaheen NJ,Wallace MB,Marcon N,Heise-Ginsburg R,Gotink AW,Wang KK,Leggett CL,Ortiz-Fernández-Sordo J,Ragunath K,DiPietro M,Pech O,Neuhaus

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  • Is esophagoscopy alone sufficient for patients with reflux symptoms?

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    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

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  • Effects of meperidine on the pancreatic and biliary sphincter.

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  • A comparison of magnifying and nonmagnifying colonoscopy for diagnosis of colorectal polyps: A prospective study.

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    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Konishi K,Kaneko K,Kurahashi T,Yamamoto T,Kushima M,Kanda A,Tajiri H,Mitamura K

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    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2005.07.048

    authors: Isenberg G,Sivak MV Jr,Chak A,Wong RC,Willis JE,Wolf B,Rowland DY,Das A,Rollins A

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    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1067/mge.2002.129212

    authors: Harbord M,Dawes RF,Barr H,Giovannini M,Viens P,Eysselein V,Mishra L,Orenberg EK,Bown SG

    更新日期:2002-11-01 00:00:00

  • Safety and usefulness of percutaneous transhepatic cholecystoscopy examination in high-risk surgical patients with acute cholecystitis.

    abstract:BACKGROUND:The aim of the present study was to evaluate the diagnostic and therapeutic usefulness of percutaneous transhepatic cholecystoscopy in high-risk surgical patients with acute cholecystitis. METHODS:Between January 1992 and June 1998, there were 33 consecutive patients who underwent percutaneous transhepatic ...

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    pub_type: 临床试验,杂志文章

    doi:10.1067/mge.2000.107286

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    更新日期:2000-11-01 00:00:00