Plant production systems for vaccines.

abstract：:Ebola hemorrhagic fever is one of the most fatal viral diseases worldwide affecting humans and nonhuman primates. Although infections only occur frequently in Central Africa, the virus has the potential to spread globally and is classified as a category A pathogen that could be misused as a bioterrorism agent. As of t...

journal_title：Expert review of vaccines

authors： Marzi A,Feldmann H

更新日期：2014-04-01 00:00:00

abstract：:The WHO has recently issued updated recommendations for the programmatic use of new-generation typhoid vaccines in high-risk areas of countries where typhoid fever is still endemic. Countries have subsequently been instructed to discuss how these recommendations can be implemented and to develop plans for targeted typ...

journal_title：Expert review of vaccines

authors： DeRoeck D,Ochiai RL,Yang J,Anh DD,Alag V,Clemens JD

更新日期：2008-07-01 00:00:00

abstract：:Vaccination has been a successful tool in the protection against many infectious diseases, and recent advances in biotechnology have created new techniques and strategies to produce safe and efficacious vaccines for human use. However, developing a protective vaccine against malaria has been a challenge. In this artic...

journal_title：Expert review of vaccines

authors： Coban C,Horii T,Akira S,Ishii KJ

更新日期：2010-07-01 00:00:00

abstract：:Introduction: Controlling the preventable infectious diseases is the main goal of vaccination. Among the vaccines, combined vaccines are of great importance for their social, public health, and economic values. It is stated that the combined vaccines are as efficient and safe as the monovalent vaccines. However, a con...

journal_title：Expert review of vaccines

authors： Tafreshi SH

更新日期：2020-10-01 00:00:00

abstract：:As pregnant women are at increased risk of influenza infection and influenza-related complications, immunization with inactivated influenza vaccine during the influenza season is recommended. Vaccination during pregnancy is considered to provide benefits for both the mothers and their young infants. In 2009, the novel...

journal_title：Expert review of vaccines

authors： Hisano M,Yamaguchi K

更新日期：2012-08-01 00:00:00

abstract：:Lassa virus (LASV) is the most prevalent arenavirus in West Africa and is responsible for several hundred thousand infections and thousands of deaths annually. The sizeable disease burden, numerous imported cases of Lassa fever (LF) and the possibility that LASV can be used as an agent of biological warfare make a str...

journal_title：Expert review of vaccines

authors： Lukashevich IS

更新日期：2013-01-01 00:00:00

abstract：:Extensive efforts aimed at stimulating immune responses by modifying HIV antigens and using various delivery systems and adjuvants have so far failed to generate promising HIV vaccines, highlighting the urgent need to explore alternative immunization approaches. Antigen-presenting cells, such as dendritic cells, play ...

journal_title：Expert review of vaccines

authors： Song XT,Aldrich M,Chen SY

更新日期：2006-08-01 00:00:00

abstract：:The epidemiology of meningococcal disease in Europe since 1945 has shown fluctuations in incidence, serogroup distribution and case-fatality rate. Outbreaks and epidemics driven by the introduction of new virulent strains into Europe have occurred unpredictably. Epidemics associated with serogroups A and B have occurr...

journal_title：Expert review of vaccines

authors： Kriz P,Wieffer H,Holl K,Rosenlund M,Budhia S,Vyse A

更新日期：2011-10-01 00:00:00

abstract：:Introduction: Influenza vaccination is regarded as the most effective way to prevent influenza infection. Due to the rapid genetic changes that influenza viruses undergo, seasonal influenza vaccines must be reformulated and re-administered annually necessitating the evaluation of influenza vaccine effectiveness (VE) e...

journal_title：Expert review of vaccines

authors： Ainslie KEC,Haber M,Orenstein WA

更新日期：2019-06-01 00:00:00

abstract：:Synthetic oligodeoxynucleotides containing unmethylated CpG motifs act as immune adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold. CpG motifs promote the production of T-helper 1 and pro-inflammatory cytokines and induce the maturation/activation of professional antigen-presen...

journal_title：Expert review of vaccines

authors： Klinman DM

更新日期：2003-04-01 00:00:00

abstract：:Introduction: Despite intensive research efforts, there is still no effective prophylactic vaccine available against HIV-1. Currently, substantial efforts are devoted to the development of vaccines aimed at inducing broadly neutralizing antibodies (bNAbs), which are capable of neutralizing most HIV-1 strains. All bNAb...

journal_title：Expert review of vaccines

authors： Del Moral-Sánchez I,Sliepen K

更新日期：2019-11-01 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in ...

journal_title：Expert review of vaccines

authors： Khan MN,Ren D,Kaur R,Basha S,Zagursky R,Pichichero ME

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Meningococcal disease has an incidence peak spread over several years during adolescence and young adulthood in the United States. Meningococcal serogroup B (MenB) vaccines have been introduced relatively recently and may help protect individuals in these age groups. Currently there is insufficient long-te...

journal_title：Expert review of vaccines

authors： Watson PS,Novy P,Bekkat-Berkani R,Strubbe F,Banzhoff A

更新日期：2019-04-01 00:00:00

abstract：:Malaria continues to be a worldwide leading cause of morbidity and mortality, and the development of an effective malaria vaccine remains a research imperative. Of the multiple approaches that have been pursued, the RTS,S/AS01 vaccine candidate represents the most developed and clinically validated malaria vaccine for...

journal_title：Expert review of vaccines

authors： Regules JA,Cummings JF,Ockenhouse CF

更新日期：2011-05-01 00:00:00

abstract：INTRODUCTION:Pneumococcal conjugate vaccine (PCV) impact studies have reported substantial reductions in the incidence of invasive pneumococcal disease (IPD) after implementation of childhood PCV programs. Heterogeneity in surveillance systems, local epidemiology and PCV programs hampers comparisons between studies. We...

journal_title：Expert review of vaccines

authors： Izurieta P,Bahety P,Adegbola R,Clarke C,Hoet B

更新日期：2018-06-01 00:00:00

abstract：:The Keystone Symposia conference, Challenges of Global Vaccine Development, attracted approximately 440 scientists, physicians and students from all around the world. The conference goal was to share newly acquired knowledge regarding vaccine-induced immunity, novel technologies, childhood vaccines, preclinical models...

journal_title：Expert review of vaccines

authors： Gudmundsdotter L,Hallengärd D

更新日期：2008-02-01 00:00:00

abstract：:Aluminum-containing adjuvants are an important component of many vaccines because they safely potentiate the immune response. The structure and properties of aluminum hydroxide adjuvant, aluminum phosphate adjuvant and alum-precipitated adjuvants are presented in this review. The major antigen adsorption mechanisms, e...

journal_title：Expert review of vaccines

authors： Hem SL,Hogenesch H

更新日期：2007-10-01 00:00:00

abstract：:With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In th...

journal_title：Expert review of vaccines

authors： Fox CB,Haensler J

更新日期：2013-07-01 00:00:00

abstract：:The Leishmania donovani glycoprotein fraction, known as FML, successfully underwent preclinical and clinical (Phase I-III) vaccine trials against canine visceral leishmaniasis (92-95% of protection and 76-80% of vaccine efficacy) when formulated with a QS21 saponin-containing adjuvant. It became the licensed Leishmune...

journal_title：Expert review of vaccines

authors： Palatnik-de-Sousa CB,Barbosa Ade F,Oliveira SM,Nico D,Bernardo RR,Santos WR,Rodrigues MM,Soares I,Borja-Cabrera GP

更新日期：2008-08-01 00:00:00

abstract：:Conjugate vaccines using diphtheria toxoid variant (CRM(197)), diphtheria toxoid and tetanus toxoid (TT) as carrier protein may induce immune interactions (interference or impairment as measured by lower antibody levels, or enhancement [higher antibody levels]) when coadministered with other vaccines. Immune enhanceme...

journal_title：Expert review of vaccines

authors： Borrow R,Dagan R,Zepp F,Hallander H,Poolman J

更新日期：2011-11-01 00:00:00

abstract：:Adolescents have the highest rates of meningococcal carriage and transmission. Interrupting the adolescent habitat in order to reduce carriage and transmission within adolescents and to other age groups could help to control meningococcal disease at a population level. Compared to immunization strategies restricted to...

journal_title：Expert review of vaccines

authors： Vetter V,Baxter R,Denizer G,Sáfadi MA,Silfverdal SA,Vyse A,Borrow R

更新日期：2016-05-01 00:00:00

abstract：:Introduction: For over 40 years, ebolaviruses have been responsible for sporadic outbreaks of severe and often fatal hemorrhagic fever in humans and nonhuman primates across western and central Africa. In December 2013, an unprecedented Ebola virus (EBOV) epidemic began in West Africa and resulted in the largest outbr...

journal_title：Expert review of vaccines

authors： O'Donnell K,Marzi A

更新日期：2020-03-01 00:00:00

abstract：:Optimal vaccine efficacy requires not only a protective antigen, but also a strong immune activator as an adjuvant. Most viral vaccines, such as influenza vaccines and nonviral genetic vaccines (e.g., DNA vaccines), contain nucleic acids, which appear to act as essential 'built-in' adjuvants. Specific receptors, inclu...

journal_title：Expert review of vaccines

authors： Koyama S,Coban C,Aoshi T,Horii T,Akira S,Ishii KJ

更新日期：2009-08-01 00:00:00

abstract：:Serogroup B Neisseria meningitidis is the leading cause of meningococcal disease in developed countries. There is currently no vaccine offering wide-ranging protection. Development of a serogroup B polysaccharide-based vaccine has been hindered by potential risks of autoantibodies that cross-react with glycosylated ho...

journal_title：Expert review of vaccines

authors： Bai X,Borrow R

更新日期：2010-10-01 00:00:00

abstract：:Buruli disease, caused by Mycobacterium ulcerans, is an emerging infectious disease in tropical areas, particularly West Africa, which can cause deep necrotizing skin lesions, called Buruli ulcer. Buruli disease affects all age groups but about 50% of the cases are diagnosed in children. There is no evidence that Buru...

journal_title：Expert review of vaccines

authors： Huygen K

更新日期：2003-08-01 00:00:00

abstract：:Conventional virus-like particles are usually composed of a single structural protein which spontaneously assembles into particles. L-particles, a little-known type of virus-like particle, are produced as part of the natural infectious process of many, if not all, alpha-herpesviruses. L-particles lack the nucleocapsid...

journal_title：Expert review of vaccines

authors： Pardoe I,Dargan D

更新日期：2002-12-01 00:00:00

abstract：:The need for an affordable, safe and effective HIV vaccine has never been greater. As the immunogenicity of all the vaccine vectors being evaluated currently in human populations is limited, novel vaccine strategies are needed to stimulate the innate immune system, to generate high levels of neutralizing antibodies an...

journal_title：Expert review of vaccines

authors： Joseph J,Saubi N,Pezzat E,Gatell JM

更新日期：2006-12-01 00:00:00

abstract：:Introduction Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), has quickly spread around the world. Areas covered This review will discuss the available immunologic and clinical evidence to support the benefit of the influenza, pneumococcal, and tuberculosis vaccines...

journal_title：Expert review of vaccines

authors： Sultana J,Mazzaglia G,Luxi N,Cancellieri A,Capuano A,Ferrajolo C,de Waure C,Ferlazzo G,Trifirò G

更新日期：2020-10-01 00:00:00

abstract：:Pneumococcal disease is a major health problem worldwide. Large, rapid declines in overall invasive pneumococcal disease and mucosal disease in children, reductions in vaccine-type disease in unvaccinated children and adults (indirect effects) and significant drops in antibiotic-resistant infections were observed afte...

journal_title：Expert review of vaccines

authors： Dinleyici EC,Yargic ZA

更新日期：2008-11-01 00:00:00

abstract：:Immunocompromised hosts are growing in number and include transplant recipients of solid organs or hematopoietic stem cells, people who have HIV, cancer patients on chemotherapy, patients on immunomodulatory treatments for rheumatologic, gastrointestinal or other conditions, as well as those with other immunocompromis...

journal_title：Expert review of vaccines

authors： Kotton CN

更新日期：2008-07-01 00:00:00