Abstract：
:The efficacy of Ketotifen was examined in the treatment of 113 infants between 6 and 36 months of age presenting with a history of cough and/or wheeze in a multicentre randomized placebo-controlled double-blind study. A 4 week no-medication baseline phase preceded the 16 week treatment phase in which infants took 2.5 mL twice daily of either placebo or Ketotifen (0.5 mg) syrup; this was followed by a 4 week wash-out phase. Diary card evaluation was performed by the parent or guardian for the duration of the study and recorded wheeze and cough twice daily as well as medication used. The percentage of symptom-free days decreased significantly in both groups (P < 0.005) with placebo-treated infants experiencing significantly more symptom-free days compared with the Ketotifen group (P < 0.01), although this difference was never more than 10% in any 4 week treatment period. Symptom severity scores and use of beta-agonist medication were also less in the placebo-treated infants but did not reach statistical significance. This study was unable to show a therapeutic advantage of Ketotifen over placebo in this group of infants with chronic cough and/or wheeze and the apparent statistical advantage of placebo is not a clinically relevant finding.
journal_name
J Paediatr Child Healthjournal_title
Journal of paediatrics and child healthauthors
van Asperen PP,McKay KO,Mellis CM,Loh RK,Harth SC,Thong YH,Harris M,Robertson IF,Gibbeson M,Rhodes Ldoi
10.1111/j.1440-1754.1992.tb02714.xkeywords:
subject
Has Abstract,Author List Incompletepub_date
1992-12-01 00:00:00pages
442-6issue
6eissn
1034-4810issn
1440-1754journal_volume
28pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：OBJECTIVE:To determine whether umbilical cord blood glucose correlates with subsequent hypoglycaemia after birth in infants of well-controlled diabetic mothers. METHODOLOGY:Thirty-eight term infants of well-controlled diabetic mothers were enrolled. Five mothers had pre-existing diabetes. Of the 33 gestational diabeti...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2000.00512.x
更新日期：2000-08-01 00:00:00
abstract：:Metatarsus adductus (MA) occurs in one to two cases per 1000 births and is the most common congenital foot deformity in newborns. The appearance is that of a curved or adducted forefoot with a normal hindfoot. A systematic literature review was conducted to answer the following question: For a child who presents with ...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,评审
doi：10.1111/jpc.12219
更新日期：2013-09-01 00:00:00
abstract：AIM:This study describes clinical staff opinions on the availability and suitability of resources to provide trauma care to children and their families and any perceived strengths, gaps and potential interventions to strengthen care. METHODS:A mixed-method study was conducted in five Australian paediatric trauma centr...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.13189
更新日期：2016-08-01 00:00:00
abstract：:Information regarding the likelihood of finding suitable marrow donors is limited. In order to determine this potential, all patients who received their primary care at a single paediatric institution over a 9 year period and in whom tissue typing studies were initiated are reviewed. Forty-five (31.3%) of 144 patients...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.1992.tb02696.x
更新日期：1992-10-01 00:00:00
abstract：:This study examined the relationship between parents' and physicians' reports of treatment-related behaviour and adjustment problems of children with cystic fibrosis (CF), and children's clinical status as assessed by measures of pulmonary functioning and global ratings of clinical status. Parents completed a Cystic F...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.1991.tb02540.x
更新日期：1991-10-01 00:00:00
abstract：OBJECTIVE:Molecular analysis of the Bruton's tyrosine kinase (Btk) gene in two unrelated families, with a combined total of seven boys, affected by X-linked agammaglobulinaemia (XLA). METHODS:Protein electrophoresis and western blotting were used for the examination of Btk protein synthesis in blood leucocytes. Isolat...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2000.00546.x
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVES:To identify and demonstrate necrotizing dermatitis in infancy; an uncommon, puzzling syndrome, in which anecdotal reporting and personal experience indicates that one third of cases may require skin grafting. Much informed discussion about the pathogenesis of this distressing syndrome centres on the role of ...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2005.00531.x
更新日期：2005-01-01 00:00:00
abstract：AIM:We aimed to review the impact of introducing binasal continuous positive airway pressure (CPAP) for acute respiratory distress in newborns ≥32 weeks gestation during retrieval in Western Australia. METHODS:Retrospective review of newborns ≥32 weeks gestation with acute respiratory distress, transported by the West...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2010.01834.x
更新日期：2010-12-01 00:00:00
abstract：:This report demonstrates the questionable usefulness of monitoring digoxin concentrations using the available immunoassays in some clinical situations. The patient reported here showed three characteristics (being a neonate with hepatic and renal impairment) that are associated with the presence of digoxin-like immuno...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.1990.tb02418.x
更新日期：1990-06-01 00:00:00
abstract：OBJECTIVE:To determine whether an association exists between passive exposure to tobacco smoke and bacterial meningitis in childhood, in an Australian population. METHODOLOGY:A retrospective, case-controlled telephone survey of the parents of 71 children admitted to the Women's and Children's Hospital, North Adelaide,...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2001.00698.x
更新日期：2001-08-01 00:00:00
abstract：OBJECTIVE:This study compares the use of standard overhead fluorescent phototherapy units with the BiliBlanket a woven fibreoptic pad which delivers high intensity light with no ultraviolet or infrared irradiation in the treatment of jaundice in preterm infants. METHODOLOGY:We chose to study infants between 800 and 25...
journal_title：Journal of paediatrics and child health
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1440-1754.1995.tb02903.x
更新日期：1995-02-01 00:00:00
abstract：AIM:Ketamine is one of the most commonly used sedatives for facilitating painful procedures for paediatric patients in the emergency department (ED). However, the use of ketamine is associated with a common, though not serious, adverse event usually called ketamine-associated vomiting (KAV). The purpose of this study i...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,随机对照试验
doi：10.1111/jpc.12515
更新日期：2014-07-01 00:00:00
abstract：:This study compared the prevalence of emotional and behavioural problems experienced by 10-11 year old and 14-15 year old children living in single-parent and two-parent families in South Australia. The 10-11 year old male children living in single-parent families were found to have significantly more emotional and be...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.1993.tb00530.x
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVE:To estimate the health burden of urinary tract infection in children less than 15 years of age in Australia and to ascertain whether any significant change has occurred during the past decade. METHODOLOGY:The number of children less than 15 years of age who were admitted in New South Wales for urinary tract ...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.1997.tb01636.x
更新日期：1997-10-01 00:00:00
abstract：OBJECTIVES:The aims of our study were to review the Royal Children's Hospital cohort of children having thyroidectomy for thyroid nodules over the last 8 years and to report the changing pattern of thyroid cancer seen in our institution over that time. METHODS:We undertook a retrospective case-note review of all patie...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2005.00724.x
更新日期：2005-11-01 00:00:00
abstract：AIM:To assess the effectiveness of oral baclofen in reducing spasticity and improving function in children with cerebral palsy. METHODS:A double-blind, randomised cross-over pilot study of oral baclofen versus placebo. Assessment tools included the Goal Attainment Scale, Pediatric Evaluation of Disability Inventory, M...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1440-1754.2006.00957.x
更新日期：2006-11-01 00:00:00
abstract：:The birthweight and gestational age specific mortality of singleton Aboriginal and White infants born in Western Australia during the period 1980-86 is described. The analyses are based on the approximately 8000 Aboriginal and 143,000 White births notified through the Western Australia Midwives' system, which were lin...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.1993.tb00439.x
更新日期：1993-02-01 00:00:00
abstract：:Intoxications, both accidental and intentional, are common in children and adolescents and often require hospitalisation and intensive treatment. Antiepileptic drugs are a possible cause of poisoning and intoxications because this category of medications has shown a rising trend in recent years. They might be responsi...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,评审
doi：10.1111/jpc.13833
更新日期：2018-05-01 00:00:00
abstract：AIM:Paediatric haematopoietic stem cell donors undergo non-therapeutic procedures and endure known and unknown physical and psychosocial risks for the benefit of a family member. One ethical concern is the risk that they may be pressured by parents or health professionals to act as a donor. This paper adds to what is k...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.12934
更新日期：2015-12-01 00:00:00
abstract：AIM:To describe a respiratory support programme for children at home by parents and layperson carers. METHODS:Analysis of records of children with long-term mechanical respiratory support at home. RESULTS:From 1979 to 2008 the programme managed 168 children (median age 7 years, range 3 weeks-19 years) with obstructiv...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2009.01618.x
更新日期：2010-01-01 00:00:00
abstract：:The public health system in Australia currently faces unprecedented challenges managing an ageing population with a rising burden of illness. Health professionals employed in the area are under constant pressure to do more with less, leading to high levels of employee dissatisfaction. Physician satisfaction is a criti...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2009.01651.x
更新日期：2010-04-01 00:00:00
abstract：AIM:To provide an overview of the health and well-being of sexual minority high school students in New Zealand, investigate differences between sexual minority youth (SMY) and exclusively opposite-sex-attracted youth (EOSAY), and examine changes across survey waves. METHODS:Nationally representative cross-sectional su...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.12727
更新日期：2015-04-01 00:00:00
abstract：AIM:Early feeding plays an important role in programming the immune system, particularly the risk of food allergy. There are many infant feeding guides published for consumers available in Australia, with most based on the National Health and Medical Research Council (NHMRC) 2012 Infant Feeding Guidelines for Health Wo...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.13594
更新日期：2017-09-01 00:00:00
abstract：:The aim of this study was to determine whether the severity of symptoms associated with rotavirus infection was related to the serotype of the infecting virus. Severity of clinical symptoms in 108 children admitted to hospital for treatment of rotavirus diarrhoea was retrospectively assessed using a scoring system for...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.1992.tb02618.x
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:To assess the prevalence of asthma and other allergies in children in Urumqi and Beijing, compared with that in Hong Kong. METHODS:A total of 7754 primary school students were randomly selected to participate in the study. Data were collected in 1995-96 using the International Study of Asthma and Allergies i...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2000.00457.x
更新日期：2000-04-01 00:00:00
abstract：AIM:The aim of this study is to compare the high-frequency pressure amplitude (oscillatory change in pressure (ΔP)) and tidal volume (high-frequency tidal volume at the airway opening (VTHF )) delivered by the Dräger VN500 (Drägerwerk Ag & Co., Lübeck, Germany) and the Sensormedics 3100 (SM3100; CareFusion, San Diego, ...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.12398
更新日期：2014-01-01 00:00:00
abstract：:Bloody nipple discharge is a rare but distressing finding in neonates and infants. We report an 8-month-old boy who showed bilateral bloody nipple discharge for 5 months without signs of infection. Ultrasound examination revealed dilated mammary ducts. This benign phenomenon is most likely caused by mammary duct ectas...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2003.00118.x
更新日期：2003-03-01 00:00:00
abstract：AIM:To determine whether information about a family history of hypercholesterolaemia or early cardiovascular disease was documented by paediatricians in children and adolescents with elevated low-density lipoprotein (LDL)-cholesterol levels. METHODS:Retrospective chart review of all children with a LDL-cholesterol lev...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/jpc.13457
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:To evaluate the usefulness of a microelectronic tablet-dispenser for monitoring adherence to preventive therapy for tuberculosis infection in adolescents. METHODOLOGY:Twenty-one patients with positive Mantoux tests were treated with isoniazid (INH), dispensed in a microelectronic tablet-dispenser that recor...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.1999.00371.x
更新日期：1999-08-01 00:00:00
abstract：AIM:To assess the clinical outcome of patients with moderate to severe cellulitis managed at a paediatric day treatment centre (DTC). METHODS:Prospective observational study of all patients (3 months to 18 years) with a presumed diagnosis of moderate to severe cellulitis made in a university-affiliated paediatric emer...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2007.01236.x
更新日期：2008-04-01 00:00:00
