A novel approach to monitoring adherence to preventive therapy for tuberculosis in adolescence.

Abstract:

OBJECTIVES:To evaluate the usefulness of a microelectronic tablet-dispenser for monitoring adherence to preventive therapy for tuberculosis infection in adolescents. METHODOLOGY:Twenty-one patients with positive Mantoux tests were treated with isoniazid (INH), dispensed in a microelectronic tablet-dispenser that recorded the date, time and duration that the container was opened. Other measures of adherence included attendance at clinic, patient self-report, tablet count, and measurement of urinary INH metabolites. RESULTS:The mean adherence rates were: 83% using attendance at clinic, 91% using tablet counts, 79% using urine assays, and 66% using the electronic tablet-dispenser. Self-reporting appeared to over-estimate adherence. CONCLUSIONS:Adherence to 6 months of INH calculated using different measures is higher in this study than in previous reports. Microelectronic tablet-dispensers are an effective method to objectively measure adherence on a daily basis. Other measures are less helpful.

authors

Starr M,Sawyer SM,Carlin JB,Powell C,Newman RG,Johnson P

doi

10.1046/j.1440-1754.1999.00371.x

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

350-354

issue

4

eissn

1034-4810

issn

1440-1754

journal_volume

35

pub_type

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