The prevalence of hepatitis C in survivors of paediatric malignancy.

Abstract:

OBJECTIVE:To assess the prevalence of hepatitis C in 200 patients with paediatric malignancies, surviving in remission more than 5 years from diagnosis, who had received blood product transfusions before 1990 when routine screening of blood products for hepatitis C began. METHOD:The second and third generation Abbott Diagnostics ELISA was used to assess hepatitis C seropositivity. Seropositive patients and those with abnormal liver transaminases were assessed by hepatitis C virus RNA polymerase chain reaction (PCR). RESULTS:A low incidence (4%) of seropositivity for hepatitis C was found in survivors of paediatric malignancy who were transfused prior to routine screening of blood products in this cohort. CONCLUSIONS:All patients identified have evidence of hepatitis and may be at high risk of developing cirrhosis.

authors

Carter TL,Cole CH,Mews CF,Price PJ,Baker DL

doi

10.1111/j.1440-1754.1997.tb01587.x

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

238-41

issue

3

eissn

1034-4810

issn

1440-1754

journal_volume

33

pub_type

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