Neonatal Candida auris infection: Management and prevention strategies - A single centre experience.

Abstract:

AIM:Our aim was to identify the clinical features and outcome of multidrug resistant Candida auris (CA) infection in neonates. METHODS:This is a retrospective case cohort study of 17 neonates who developed sepsis caused by CA infection in a tertiary care neonatal intensive care unit over 3 years. The risk factors, clinical features, treatment and outcome were studied. RESULTS:The mean gestation was 32.4 ± 4.9 weeks with overall mortality of 41%. Clinical features were indistinguishable from other causes of sepsis. CA was sensitive to micafungin but resistant to fluconazole and had variable sensitivity to voriconazole and amphotericin. Survival improved to 83% when infants were treated with a combination of micafungin and amphotericin. Non-survivors were of lower birthweights and had other risk factors. CONCLUSIONS:The management guidelines and infection control measures are described in this largest series of neonatal CA infection. Treatment with a combination of amphotericin and micafungin improved the outcome.

authors

Chandramati J,Sadanandan L,Kumar A,Ponthenkandath S

doi

10.1111/jpc.15019

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

1565-1569

issue

10

eissn

1034-4810

issn

1440-1754

journal_volume

56

pub_type

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