Oral baclofen in children with cerebral palsy: a double-blind cross-over pilot study.

Abstract:

AIM:To assess the effectiveness of oral baclofen in reducing spasticity and improving function in children with cerebral palsy. METHODS:A double-blind, randomised cross-over pilot study of oral baclofen versus placebo. Assessment tools included the Goal Attainment Scale, Pediatric Evaluation of Disability Inventory, Modified Tardieu Scale and parent questionnaire. RESULTS:Fifteen children with mean age 7.4 years (SD=2.7 years) and spastic or spastic/dystonic quadriplegia (Gross Motor Function Classification System Level IV or V) were enrolled. Children scored significantly better on the Goal Attainment Scale with baclofen compared with placebo (F(1,13)=4.5, P=0.05). There was no significant difference between baclofen and placebo for the Pediatric Evaluation of Disability Inventory or Modified Tardieu Scale. Parent questionnaire results are described. CONCLUSION:This pilot study demonstrates that oral baclofen has an effect beyond placebo in improving goal-oriented tasks, such as transfers, in children with spastic quadriplegic cerebral palsy.

authors

Scheinberg A,Hall K,Lam LT,O'Flaherty S

doi

10.1111/j.1440-1754.2006.00957.x

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

715-20

issue

11

eissn

1034-4810

issn

1440-1754

pii

JPC957

journal_volume

42

pub_type

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