Abstract:
AIM:To assess the effectiveness of oral baclofen in reducing spasticity and improving function in children with cerebral palsy. METHODS:A double-blind, randomised cross-over pilot study of oral baclofen versus placebo. Assessment tools included the Goal Attainment Scale, Pediatric Evaluation of Disability Inventory, Modified Tardieu Scale and parent questionnaire. RESULTS:Fifteen children with mean age 7.4 years (SD=2.7 years) and spastic or spastic/dystonic quadriplegia (Gross Motor Function Classification System Level IV or V) were enrolled. Children scored significantly better on the Goal Attainment Scale with baclofen compared with placebo (F(1,13)=4.5, P=0.05). There was no significant difference between baclofen and placebo for the Pediatric Evaluation of Disability Inventory or Modified Tardieu Scale. Parent questionnaire results are described. CONCLUSION:This pilot study demonstrates that oral baclofen has an effect beyond placebo in improving goal-oriented tasks, such as transfers, in children with spastic quadriplegic cerebral palsy.
journal_name
J Paediatr Child Healthjournal_title
Journal of paediatrics and child healthauthors
Scheinberg A,Hall K,Lam LT,O'Flaherty Sdoi
10.1111/j.1440-1754.2006.00957.xsubject
Has Abstractpub_date
2006-11-01 00:00:00pages
715-20issue
11eissn
1034-4810issn
1440-1754pii
JPC957journal_volume
42pub_type
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journal_title:Journal of paediatrics and child health
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journal_title:Journal of paediatrics and child health
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更新日期:2009-09-01 00:00:00
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journal_title:Journal of paediatrics and child health
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pub_type: 杂志文章,评审
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