Abstract:
:The molecular substructure of human articular cartilage has been difficult to study because of its complex composition and high degree of hydration. Using newly available small-angle X-ray diffraction (SAX) instrumentation that allows very short exposure times (0.1 to 10 sec), we have obtained spatially resolved information concerning the disposition of collagen fibers in the matrix of cartilage from the normal and osteoarthritic ankle and knee joints of human cadavers. Surprisingly, in zones of cartilage damage, such as in preosteoarthritic lesions or in the severely degenerated cartilage of osteoarthritic joints, collagen fibers of the deeper layers tended to be reoriented from the vertical. The SAX technique represents a nondestructive method of analyzing the collagen network in cartilage. Taken together, the data suggest a rigid control mechanism for the fiber network and an extensive passive reorganization of the collagen fiber orientation in diseased joint cartilage.
journal_name
Connect Tissue Resjournal_title
Connective tissue researchauthors
Mollenhauer J,Aurich M,Muehleman C,Khelashvilli G,Irving TCkeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
201-7issue
5eissn
0300-8207issn
1607-8438pii
NM6QFQN4GD7QLB7Yjournal_volume
44pub_type
杂志文章abstract::Heparin treated and aldehyde crosslinked rat aorta segments were implanted in infrarenal aorta of homologous rats. One year following aortic replacement, the subendothelial scar and the prosthetic remnants were excised. The scar and the host intima-media were incubated with 3H-valine for 4 h and extracted with 5 M gua...
journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008208309005609
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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journal_title:Connective tissue research
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更新日期:2016-11-01 00:00:00
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journal_title:Connective tissue research
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doi:
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journal_title:Connective tissue research
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doi:10.3109/03008208809015023
更新日期:1988-01-01 00:00:00
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abstract::Of more than 2 million segmental bone defects repaired annually with bone autografts and allografts, 15-40% fail. Improving healing rates may be approached with tissue engineering and use of periosteum overlying an allograft. The present study documents gene expression in human periosteum-allograft constructs compared...
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journal_title:Connective tissue research
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更新日期:1995-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00