Abstract:
:Metallothioneins (MT) represent low molecular weight proteins that are supposed to fulfil several functions. They participate in the cell cycle, protect cells from oxidative stress, control levels of heavy metals and participate in multidrug resistance processes, particularly in cases of alkylating drugs. The present study aimed at evaluation of proliferation intensity (Ki67, PCNA) in ovarian cancers treated using cisplatin and paclitaxel, as related to expression of MT. The experiments were performed on samples originating from 10 patients operated on due to ovarian cancer. The material originated from the first operations or second-look operations. All the patients were treated with cisplatin and paclitaxel. Immunocytochemical reactions using antibodies to MT, Ki67 and PCNA were performed in paraffin sections originating from the cases studied. Statistical analysis was performed using Statistica software. The studies demonstrated no relation between expression of MT on the one hand and intensity of proliferation before or after chemotherapy on the other hand (gamma correlation, p > 0.05). The results indicate that expression of MT is not related to resistance to treatment using cisplatin and paclitaxel.
journal_name
Folia Morphol (Warsz)journal_title
Folia morphologicaauthors
Surowiak P,Kaplenko I,Spaczyński M,Zabel Mkeywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
493-5issue
4eissn
0015-5659issn
1644-3284journal_volume
62pub_type
杂志文章abstract:BACKGROUND:The study investigates the size of the foramen ovale (FO) in relation to the presence and absence of the emissary sphenoidal foramen (ESF). Any possible alteration of the FO size in relation to the ESF (unilateral or bilateral) presence and absence was also examined. MATERIALS AND METHODS:One-hundred and ni...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2017.0068
更新日期:2018-01-01 00:00:00
abstract::The ultrastructure, fundamental chemistry, and processing modes of fully synthetic bone grafting materials are relevant to the reconstruction of osseous defects. Rapid progress in the profitable market of biomaterials has led to the development of various bone substitutes. Despite all these efforts, an ideal and full ...
journal_title:Folia morphologica
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更新日期:2006-02-01 00:00:00
abstract::Investigations were made on serial sections of human embryos at developmental stage 23 (56 days). The oculomotor complex in embryos at this stage consists of lateral, median, and accessory nuclei. The lateral (chief) nucleus forms the greatest part of the oculomotor complex and it is subdivided into ventromedial and d...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract::Exercise has been shown to be beneficial to the skeleton, in both humans and animals. This study was done to test the sex-related difference in the risk of OA (osteoarthritis) of the knee joint and also on the subchondral bone after moderate running exercise. Forty male and female Wistar rats were randomly assigned to ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2020.0030
更新日期:2020-03-11 00:00:00
abstract:BACKGROUND:The vertebral artery originates from the subclavian artery and is divided into four segments. The aim of this study is to investigate the anatomical variations in the course and branches of the vertebral artery. M: ATERIALS AND METHODS: : A research was performed via Pubmed database, using the terms; "variat...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2020.0022
更新日期:2020-02-19 00:00:00
abstract::The pelvic plexus is observed in human embryos at stage 15 and during the last two embryonic weeks the secondary plexuses are formed. The pelvic nerves are found at stage 15 and in embryos they arise from anterior rami of the sacral nerves S2-S4. In fetuses the pelvic nerves originate from the anterior rami S1-S5. Num...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The present study was aimed at disclosing the influence of Bacteroides fragilis (one of the most important bacterial agents causing colitis in children) experimental infection on the expression of substance P (SP) and somatostatin (SOM) in neurons and nerve fibres within the porcine ascending colon. Distinct differenc...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract::The authors retrospectively reviewed the cytological slides of 44 histopathologically confirmed fibroepithelial lesions of the breast, of which 11 were fibroadenoma (FA), 19 benign phyllodes tumours (PTLGM), 8 borderline (PTBM) and 6 malignant (PTHGM). The 2 FA misdiagnosed as PTLGM in cytological smears were both of ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:The contribution of glial cells to the pathophysiology of depression is an emerging research purpose. This study investigated the deficits in glial cells, specifically astrocytes in various brain regions, after the development of depression and then after voluntary running in depressed rats. MATERIALS AND M...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2020.0007
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Fluorescence-guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) his proven to assist neurosurgeons to achieve a more complete brain tumour resection. However, 5-ALA-guided surgery is limited since it is often difficult to distinguish the colour difference between the resected areas of malignant brain tu...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2020.0035
更新日期:2020-03-24 00:00:00
abstract::Based on standard histological methods and specific injection technique, the study demonstrates for the first time the blood vessel system of the scrotal integument.The latter is relatively thin and shows a thick underlying fascia, the tunica dartos. The vessel networks found in both structures are somewhat different ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/fm.2013.0022
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Left renal vein (LRV) variations occur in 0.8-10.2% of the population. The most common LRV variations are retroaortic left renal vein (RLRV) and circumaortic left renal vein (CLRV). The purpose of this study is to determine the frequency of LRV variations in a large series on computed tomography (CT) and to ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2019.0137
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:Numerous fibrous elements known as the Willis chords are situated in the light of the superior sagittal sinus. The paper is aimed at a comparative evaluation of the appearance of the Willis chords appearing in the superior sagittal sinus during various periods of human life and a determination of their role....
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The size and shape of the thyroid gland is subject to much variation, as stated by Wood Jones. Literature is replete with a large number of variations of the gland. By utilizing various techniques like gross dissection, histology, developmental anatomy, and recently thyroid scans and scintigraphy, some common and cert...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Frontal aslant tract (FAT) is a white matter bundle connecting the pre-supplementary motor area (pre-SMA) and the supplementary motor area (SMA) with the inferior frontal gyrus (IFG). The purpose of the present study was to evaluate the anatomical variability of FAT. MATERIALS AND METHODS:Total number of fi...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2017.0039
更新日期:2017-01-01 00:00:00
abstract::Methyl parathion (MP) is a pesticide widely used to protect crops but also illegally used in many countries for spraying homes and businesses to contain insects. The present study was planned to investigate the effects of MP on the male reproductive organs in the rat. Male Wistar rats (13-14 weeks old) were treated wi...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract::We encountered some multiple vessel variations in the retropubic region of a 55-year-old male cadaver. The obturator artery had its origin from the external iliac artery, and inferior epigastric artery from the femoral artery. Additionally, an anastomosis between obturator and inferior epigastric veins (venous Crown o...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Cyclo-oxygenase (COX), which catalyses the conversion of arachidonic acid to prostaglandin endoperoxide and prostanoids, is widely expressed in mammalian organs. The aim of the study was to evaluate the immunoexpression of the constitutive and inducible cyclo-oxygenase isoforms (COX-1 and COX-2 respectively) in the oe...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract::Ultrastructural response of photoreceptors to 10 days of treatment with reserpine and bromocryptine, and to 10 days of illumination, was studied. Treatment with isoproterenol was also applied in some experiments with continuous illumination. Treatment with bromocryptine and reserpine induced elongation of rod outer se...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2014.0040
更新日期:2014-08-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2018.0072
更新日期:2019-01-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2020.0045
更新日期:2020-04-17 00:00:00
abstract::The purpose of this study was to analyse the occurrence of variants of anomalous insertions of the anterior horn of the medial meniscus in human knee joints. The study was carried out on 78 human lower limbs of both sexes (42 males and 36 females). Out of 78 knee joints, 10 knee joints (12.82%) presented atypical atta...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::In 18 animals morphology of the tarsal, metatarsal and digital pulps of the both pelvic limbs was studied. Measurements of length and width of the pulps were also made. ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The investigation was carried out on 16 human foetal cadavers at the age of 17-23 weeks from the time of conception. The foetal vascular system was injected with the synthetic resin MERCOX CL-2R and analysed in scanning electron microscope.The vascular system of the foetal spinal cord was studied. The foetal vascular ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2014.0020
更新日期:2014-05-01 00:00:00
abstract::In 1989 Leitbrock et al. reported the full primary structure of brain-derived neurotrophic factor. The messenger RNA for BDNF was found predominantly in the central nervous system, and the sequence of protein indicated its structural relation to NGF. BDNF belongs to a larger family of neurotrophic molecules. It stimul...
journal_title:Folia morphologica
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract::The South American fur seal reproductive histophysiology is scarcely described. This study provides a histological description of prepuberal South American fur seal (Arctocephalus australis) ovaries as well as three-dimensional reconstructions of subcapsular crypts and primordial follicles. Ovaries from fresh dead ani...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:The anatomy of the human nasal cavity (NC) is complex and its structures are closely related to the functions of the NC. Studies which assessing the mean volumes of NC and conchae are very infrequent. The purpose of current study is to investigate development of NC and conchae according to age and sex by usi...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2015.0078
更新日期:2016-01-01 00:00:00
abstract::The aim of the research was to examine the anatomy of the arterial system in the inguinal region, hip and thigh of Papio anubis. No description of this was found in the available scientific literature, although, at the same time, the baboon is considered to be a good animal model in biomedical research. Macroscopic an...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00