Abstract:
BACKGROUND:The contribution of glial cells to the pathophysiology of depression is an emerging research purpose. This study investigated the deficits in glial cells, specifically astrocytes in various brain regions, after the development of depression and then after voluntary running in depressed rats. MATERIALS AND METHODS:Forty-five adult male Wistar rats aged 8-10 weeks were used in the study. A depression model was generated through a forced swimming programme; voluntary running was allowed on rat running wheels; and brain sections were taken from the hippocampus, dentate gyrus (DG), medial prefrontal cortex (mPFC) and cerebellar cortex. After immunostaining with specific antibodies immuno-stain, the astrocytes, oligodendroglia and microglial cells were counted, and certain indices relating astrocytes to other glial cells were calculated. Astrocytic morphology was studied, and the optical density (OD) of glial fibrillary acidic protein (GFAP) immuno-expression was measured in different groups. RESULTS:Compared to the control group, animals in the depression group exhibited significant decreases in the mean astrocyte count in all studied brain areas, significant decreases in GFAP OD values in all areas and significantly reduced values for all glial astrocyte indices in the hippocampus, DG and mPFC. Compared to the rats in the depression group, those in the depression/exercise group exhibited significantly elevated mean astrocyte and oligodendroglia counts in all studied areas, significantly elevated GFAP OD values in all studied areas, and non-significant differences in glial astrocyte indices in the hippocampus, mPFC and cerebellar cortex. CONCLUSION:Astrocytes, rather than other glia, constitute a basis for the development and/or relief of depression.
journal_name
Folia Morphol (Warsz)journal_title
Folia morphologicaauthors
Eldomiaty MA,Makarenko O,Hassan ZA,Almasry SM,Petrov P,Elnaggar AMdoi
10.5603/FM.a2020.0007subject
Has Abstractpub_date
2020-01-01 00:00:00pages
419-428issue
3eissn
0015-5659issn
1644-3284pii
VM/OJS/J/66745journal_volume
79pub_type
杂志文章abstract::Exercise has been shown to be beneficial to the skeleton, in both humans and animals. This study was done to test the sex-related difference in the risk of OA (osteoarthritis) of the knee joint and also on the subchondral bone after moderate running exercise. Forty male and female Wistar rats were randomly assigned to ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2020.0030
更新日期:2020-03-11 00:00:00
abstract::The morphological study of the development of "intimal thickenings" of the human uterine artery in physiological condition was performed on 72 uterine arteries obtained from foetuses from the 12th week of gestation up to birth. Our results indicate that intimal thickening is formed by the migration and displacement of...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Among authors studying morphological determinants of the obstructive sleep apnoea (OSA) controversies exist on the location of the narrowest area within the pharynx, critical for development of obstruction. Those disagreements primarily revolve around differences between obese and nonobese OSA patients. Dete...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2017.0018
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Many different surgical techniques have been developed to remove open mastoid cavities. In addition to autologous materials, alloplastic substances have been used. A very slow absorption of these materials and extrusion reactions have been reported. We investigated a newly developed, highly porous bone graft...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Atherosclerotic occlusion of a coronary vessel is the commonest cause of ischaemic heart disease. The distribution of atherosclerotic lesions is not random,with stenoses preferentially situated at branch ostia, bifurcation points, and the proximal segments of daughter vessels. The aim of this study was to de...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/fm.2013.0033
更新日期:2013-08-01 00:00:00
abstract::To revisit foetal development of the deep flexor tendons of the hand and foot, we examined the paraffin-embedded histology of 20 mid-term foetuses at 8-15 weeks of estimated gestational age (35-118 mm crown-rump length or CRL). At 8-9 weeks, in front of the metacarpal bones, the flexor pollicis longus and flexor d...
journal_title:Folia morphologica
pub_type: 临床试验,杂志文章
doi:
更新日期:2012-08-01 00:00:00
abstract::Data for the force necessary to fracture the isolated calvaria (skull cap) are not available in the extant literature. Twenty dry adult calvaria were tested to failure quasistatically at the vertex using a 15-kN load cell. The forces necessary to fracture or cause diastasis of calvarial sutures were then documented an...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract::There have been no reports on how the light-dark changes determine the locomotor activity of animals in the group of high reactivity (HR) and low reactivity (LR). In the present study we have compared selected parameters of the locomotor activity of the HR and the LR groups of the laboratory opossums and Wistar rats d...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/fm.2013.0050
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:The pterygoid hamulus (PH) is a small protrusion on the base of the pterygoid process of the sphenoid bone. PH is a site of insertion of many muscles and ligaments. Its topography can determine predilection for developing the pterygoid hamulus bursitis (PHB). MATERIALS AND METHODS:The study was conducted ba...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2019.0049
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to identify and compare the various morphological characteristics of rugae palatinae in males and females of adult Sudanese Nubians and to assess the existence of side asymmetry. Furthermore, the possibility of assigning sex utilising dimensions, shapes, and orientations was explore...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2015.0046
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The Common Iliac Arteries are the two terminal branches of the abdominal aorta which supply the pelvis and the lower extremities. The present study aims to examine the morphometric features of the common iliac arteries in a cadaveric sample and possible correlations between lengths. MATERIALS AND METHODS:Se...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2020.0109
更新日期:2020-09-08 00:00:00
abstract::Neural and vascular variations in the axilla and upper limb area are usually paired, but coexistence of muscular aberration on top of this is uncommon. The current case report emphasizes on the unilateral coexistence of a three-headed (tricipital) biceps brachii muscle, a two-headed coracobrachialis with an accessory ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2018.0081
更新日期:2019-01-01 00:00:00
abstract::The present study was aimed at disclosing the influence of Bacteroides fragilis (one of the most important bacterial agents causing colitis in children) experimental infection on the expression of substance P (SP) and somatostatin (SOM) in neurons and nerve fibres within the porcine ascending colon. Distinct differenc...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract::A sartorius muscle is the longest muscle of the human system. It runs over 2 joints- hip and knee joints. In the study 10 sartorius muscles were examined. They were dissected free of lower human limbs. Dimensions of limbs which these muscles come from and dimensions of the muscles and their component parts were examin...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2014.0037
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Persistent left superior caval vein (PLSCV) is a rare, anatomically diverse developmental anomaly of systemic veins. Clinically asymptomatic PLSCVs are detected incidentally during medical procedures that utilise systemic veins, such as cardiac implantable electronic device (CIED) placement, and whose succes...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2016.0042
更新日期:2017-01-01 00:00:00
abstract::Investigations were carried out on 43 serially sectioned human embryos of developmental stages 18 to 23. The homogeneous interzone of the future knee joint is observed in embryos at stage 18. During stage 19 this interzone is differentiated into dense, intensively stained, peripheral parts, which are the primordia of ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::The role of the parafollicular (C) cells, the second most important cells in the thyroid gland, has not hitherto been clarified. They are considered to be disperse neuroendocrine cells of the APUD system and synthesise and release many of the regulatory peptides. Few publications are concerned with the evaluation of t...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:A narrow internal auditory canal (IAC) is significantly associated with congenital sensorineural hearing loss. It would therefore seem likely that any patient with an IAC measured radiographically to be under the normal range represents an abnormality and probable IAC stenosis. If narrow IAC is diagnosed wit...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2012-11-01 00:00:00
abstract::In the material of 300 kidneys, collected from adult corpses of both sexes, the presence of double renal pelvis and duplicated ureter within the renal hilus was detected in 4 cases. In the investigated double kidneys the number of segmental arteries ranged from 4 to 6. In two out of the examined organs there were doub...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The arterial fibrous rings were investigated in human embryos aged 7 and 8 weeks under light and scanning electron microscopes. In the present study it was shown that the arrangement of collagen and formation of fibres changes rapidly within one week. In the 7(th) week there are no collagen fibres and the netlike fibr...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2010-08-01 00:00:00
abstract::A study was made of human embryos at the end of 8 weeks and foetuses aged 9 weeks. It was shown that at the beginning of the foetal period the cortical plate, which is the primordium of the neocortex, covers the whole surface of the cerebral hemisphere. The plate consists of 8-12 rows of densely packed cells. Below th...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract::We encountered variation in the formation of the median nerve in a 66-year-old male cadaver during dissection of the upper extremity of 20 adult cadavers. The dissections were made at the Department of Cellular Biology and Anatomy, Louisiana State University Medical Center. The median nerve was formed by fusion of fou...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::A rare case of fenestration of the left middle cerebral artery (MCA) is presented. There is a coexistence with hypoplasia of precommunicans part of the right posterior cerebral artery and its "fetal" branching from internal carotid artery. This form of variation may cause mistakes during interpretation of angiographic...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::The giant armadillo (Priodontes maximus) is found in diverse habitats from South America. A female adult giant armadillo with a body mass of 45 kg was used. The animal was a victim of trampling on highway AC-40, at 70 km, near the municipality of Capixaba-Acre and the corpse donated to the Animal Anatomy Laboratory at...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2019.0053
更新日期:2020-01-01 00:00:00
abstract::Mature male rats received encortone in a dose of 1 mg/kg of body mass for 7 days and 30 days. The following changes were observed in the cells of parotid gland of the experimental animals in comparison with the control: a) after 7 days of encortone treatment increase of secretory cells activity appeared in the intensi...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:This study was conducted to determine the morphometric features and to make the three-dimensional (3D) reconstruction of the images obtained by computed tomography (CT) of the main long bones (femur, tibia, fibula) in Van cats, and to reveal the biometric differences between these measurement values of both ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2020.0116
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:The hippocampal formation (HF) is one of the most important parts of the brain in the magnetic resonance imaging (MRI) volumetric analysis in various domains, but not completely from all aspects, including the handedness. The aim of our study was to evaluate the possible differences in the volume of the righ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2015.0102
更新日期:2015-01-01 00:00:00
abstract::A study was performed on 12 human embryos at developmental stages 16 and 17 (6(th) week). In the investigated embryos the primary palate is formed from medial nasal, lateral nasal, and maxillary processes. The medial and lateral nasal processes merge and form the nasal fin at stage 16. This fin regresses and at stage ...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2011-02-01 00:00:00
abstract::A comparison of the data published in anatomy textbooks and anthropological tables does not reveal any change in basic heart dimensions during the period since the beginning of the 20th century to nowadays. However, normal values of many other parameters have changed up to 30% over the same period. These changes may b...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract::Localisation of the diaphorase activity of nicotinamide adenine dinucleotide phosphate (NADPH-d), acting as a marker of nitric oxide synthesis (NOS), was studied in the thymus of the rat, mouse and rabbit. The NADPH-d-active cells observed in the rat thymus were irregular in shape with numerous projections and were lo...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00