Abstract:
:Our studies were carried out on the hearts of virgin female Wistar rats treated with 100,000 i.u. of vitamin D3 (calciol) per os for 3 consecutive days. Multifocal cardionecrosis was established macroscopically in 70% of the vitamin D-treated rats on the 7th day of the experiment when the rats were in the acute phase of intoxication. Using a scanning electron microscopy (SEM), we received three-dimensional information about the structural changes to the rat myocardium damaged by high doses of vitamin D3. The images of necrotic hearts revealed significant disruption of the structural integrity of the myocardium linked to fragmentation of the cardiac muscle bundles and a visible disruption of the extracellular matrix (ECM) components. In healthy hearts, the structural integrity of the myocardium and the dense network of the extracellular matrix were well preserved. In parallel, the effect of an increasing concentration of free Ca2+ on the total proteolytic activity of the heart muscle homogenate of the healthy and necrotic rats was investigated at neutral pH. These data showed that following vitamin D3 intoxication, the proteolytic processes in the rat hearts occurred in Ca2+ overload or saturation. On the basis of our morphological and biochemical results we can suggest that calcium-activated neutral proteinases may have contributed to the structural alteration of the extracellular matrix components and were in this way involved in vitamin D-induced cardionecrosis.
journal_name
Folia Morphol (Warsz)journal_title
Folia morphologicaauthors
Walentynowicz O,Kubasik-Juraniec J,Rudzińska-Kisiel Tkeywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
439-44issue
4eissn
0015-5659issn
1644-3284journal_volume
63pub_type
杂志文章abstract::Laryngeal nerves have been observed to communicate with each other and forma variety of patterns. These communications have been studied extensively and have been of particular interest as it may provide an additional form of innervation to the intrinsic laryngeal muscles. Variations noted in incidence may help explai...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2014.0005
更新日期:2014-02-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章,评审
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2017.0068
更新日期:2018-01-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Folia morphologica
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更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Sertoli cells are important in determining the fate of spermatogenic cells by providing nutrition and structural support via cell junctions. Adhesion between Sertoli and germ cells is important for spermatogenesis. Cadherin are transmembrane proteins that mediate cell-cell adhesion, while, vimentin, the cyto...
journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2014.0050
更新日期:2014-08-01 00:00:00
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journal_title:Folia morphologica
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doi:
更新日期:2004-02-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2017.0004
更新日期:2017-01-01 00:00:00
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journal_title:Folia morphologica
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journal_title:Folia morphologica
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2018.0026
更新日期:2018-01-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.2014.0030
更新日期:2014-05-01 00:00:00
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journal_title:Folia morphologica
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更新日期:2008-02-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/FM.a2017.0039
更新日期:2017-01-01 00:00:00
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journal_title:Folia morphologica
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journal_title:Folia morphologica
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journal_title:Folia morphologica
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更新日期:1992-01-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:10.5603/fm.2013.0043
更新日期:2013-08-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Folia morphologica
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更新日期:2009-11-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Folia morphologica
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更新日期:2001-01-01 00:00:00
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journal_title:Folia morphologica
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00