Abstract：
BACKGROUND:Spinal muscular atrophy is a rare genetic disease, which primarily affects motor neurons and predominantly occurs in children. To date, alternatives for the treatment of the disease have been controversial. Spinal muscular atrophy has a multi-factorial aetiology, with mitochondrial oxidative stress considered as the crucial pathogenic mechanism. To determine the mechanisms underlying the loss of motor neurons, NSC-34 motor neuron-like cells are often used as an in vitro model of spinal muscular atrophy. As plastin 3 (PLS3) has been demonstrated as a modifier of spinal muscular atrophy, the aim of the current study was to evaluate the neuroprotective effect of PLS3 in NSC-34 cells. MATERIALS AND METHODS:Plastin 3 was overexpressed in human embryonic kidney 293T cells and NSC-34 cells via lentiviral transduction. NSC-34 cells transduced with a lentiviral vector carrying the gene for LacZ β-galactosidase served as a control. Oxidative stress was then induced by depriving cells of serum, and the protective effect of PLS3 was assessed using a cellular reactive oxygen species detection assay. RESULTS:While PLS3 was successfully overexpressed in human embryonic kidney 293T cells and NSC-34 cells, upregulation of this protein did not significantly decrease oxidative stress in serum-deprived NSC-34 cells relative to controls. CONCLUSIONS:Plastin 3 overexpression in NSC-34 cells did not elicit an antioxidative effect following serum deprivation.
journal_name
Folia Morphol (Warsz)journal_title
Folia morphologicaauthors
Alrafiah ARdoi
10.5603/FM.a2018.0072subject
Has Abstractpub_date
2019-01-01 00:00:00pages
1-9issue
1eissn
0015-5659issn
1644-3284pii
VM/OJS/J/58597journal_volume
78pub_type
杂志文章abstract：BACKGROUND:Medial depression of the mandibular ramus (MDMR) is an anatomical depression with unknown aetiology and described as a result of a slender mandibular ramus in the area of the mandibular notch. It is suggested that MDMR may be due to variations in muscle functions. The aim of this study is to compare the bite...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/FM.a2018.0026
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Among authors studying morphological determinants of the obstructive sleep apnoea (OSA) controversies exist on the location of the narrowest area within the pharynx, critical for development of obstruction. Those disagreements primarily revolve around differences between obese and nonobese OSA patients. Dete...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/FM.a2017.0018
更新日期：2017-01-01 00:00:00
abstract：:Investigations were made on serial sections of human embryos at developmental stage 23 (56 days). The oculomotor complex in embryos at this stage consists of lateral, median, and accessory nuclei. The lateral (chief) nucleus forms the greatest part of the oculomotor complex and it is subdivided into ventromedial and d...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Third molar teeth are causative factors of many oral pathologies. Lower third molars are the most often retained teeth and the origin of considerable pain. The aim of the study is a presentation of the morphology of third molars with incompletely formed apices on the basis of panoramic radiograms. The material compris...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:When closed by the superior transverse scapular ligament (STSL), the suprascapular notch (SSN) creates an osseo-fibrous tunnel which acts as a pathway for the suprascapular nerve (SN). Anatomical variations are common in this region, and these can increase the risk of neuropathy by restricting the space for ...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/FM.a2016.0018
更新日期：2016-01-01 00:00:00
abstract：:Metallothioneins (MT) represent low molecular weight proteins that are supposed to fulfil several functions. They participate in the cell cycle, protect cells from oxidative stress, control levels of heavy metals and participate in multidrug resistance processes, particularly in cases of alkylating drugs. The present ...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:Using the thiocholine method of Koelle and Friedenwald and histological techniques, the otic ganglion in Egyptian spiny mouse (Acomys cahirinus, Desmarest) was studied. The ganglion was found to be a single oval cluster of neurocytes, situated at the medial and posterior surface of the mandibular nerve just above the ...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Inguinal hernia repairs are very common yet fairly complex surgical procedures.Variations in the anatomical course of the inguinal nerves require that diligence is taken in their proper recognition. Inadvertent surgical injury to these nerves is associated with long term postoperative pain and complications. The aim o...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/fm.2013.0043
更新日期：2013-08-01 00:00:00
abstract：:The aim of the paper is computer transformation of the transversal research results of male (214) and female (178) genital internal organs (examined in 4 months's intervals) in a way enabling longitudinal evaluation. ...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:The contribution of glial cells to the pathophysiology of depression is an emerging research purpose. This study investigated the deficits in glial cells, specifically astrocytes in various brain regions, after the development of depression and then after voluntary running in depressed rats. MATERIALS AND M...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/FM.a2020.0007
更新日期：2020-01-01 00:00:00
abstract：:The giant armadillo (Priodontes maximus) is found in diverse habitats from South America. A female adult giant armadillo with a body mass of 45 kg was used. The animal was a victim of trampling on highway AC-40, at 70 km, near the municipality of Capixaba-Acre and the corpse donated to the Animal Anatomy Laboratory at...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/FM.a2019.0053
更新日期：2020-01-01 00:00:00
abstract：:Folds of the meningeal layer of the dura mater, the falx cerebri and tentorium cerebelli, traverse the vertebrate intracranial cavity and thus compartmentalise the brain. The falx cerebelli, another dural fold, is found in the posterior cranial fossa and attaches to the inferior aspect of the tentorium cerebelli and t...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：:This study was conducted to assess the effect of melatonin on the structure of testis and spermatogenesis dynamics in neonate vitrified testis grafts. Neonate vitrified testes, candidates for transplantation heterotopically to experiment or control groups, were warmed in thawing media which had or did not have a suppl...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2011-05-01 00:00:00
abstract：:Oligodendrocytes, called oligodendroglia, are present in the white and grey substance of the CNS. They constitute a heterogeneous group, in which 3 types of these cells have been distinguished: those of light, medium and dark cytoplasm. They locate themselves at the neurones and blood vessels. The number of light olig...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:We identified the vidian canal (VC) in a Turkish subpopulation on cone-beam computed tomography (CBCT) images and explored its anatomic relationships; the canal serves as an anatomic pathway during endonasal surgical approaches. MATERIALS AND METHODS:Coronal and axial CBCT images of 100 patients (50 males a...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/FM.a2019.0094
更新日期：2020-01-01 00:00:00
abstract：:Anatomical variations of the transverse cervical and suprascapular arteries are common. We report an adult male cadaver found to harbour an unusual variation of the right course of these two arteries. The transverse cervical artery arose independently from the first segment of the subclavian artery and passed deep to ...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2007-02-01 00:00:00
abstract：:Studies were carried out on 100 right lungs taken from human cadavers of both sexes aged from 1 month to 80 years. The material was divided into 3 age groups. The pulmonary artery and the bronchi were injected with 65% duracryl and then digested in sulfuric acid. Specimens were examined to determine the number and dim...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Our studies were carried out on the hearts of virgin female Wistar rats treated with 100,000 i.u. of vitamin D3 (calciol) per os for 3 consecutive days. Multifocal cardionecrosis was established macroscopically in 70% of the vitamin D-treated rats on the 7th day of the experiment when the rats were in the acute phase ...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：:Although anatomical variations in the upper limb are frequent, coexistence of multiple combined variations is rare. During a routine educational dissection at Jeju National University Medical School, three muscular variations were found in a 75-year-old Korean male cadaver, in which a supraclavicular cephalic vein was...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/FM.a2018.0048
更新日期：2019-01-01 00:00:00
abstract：:Histological studies of the brain, lungs, liver, kidneys, heart, and the spleen were carried out in mice previously infected with 6 pathogenic strains of free-living amoebae of the genus Acanthamoeba. The potential virulence of the strains studied was determined on the basis of re-isolation of the amoebae from the org...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
abstract：:The frequency of occurrence and topography of the outfow portions of the posterior veins of the left ventricle were observed. One hundred fifty adult human hearts of both sexes from l8 to 85 years of age fixed in a formalin/ethanol solution were examined. Classical macroscopic anatomical examination methods were used....
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Diverticula of the upper part of the alimentary tract, irrespective of their etiology, are frequently observed benign changes of the pharynx, oesophagus, stomach and duodenum. In the present work, patients of the II General Surgery Department of the Medical University of Lublin, with radiologically or endoscopically p...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：:The aim of the study was to evaluate the physiological developmental changes of male rats' lumbar vertebrae during the first 22 days after birth. Morphology and mineralisation of lumbar vertebrae were evaluated using double-staining and digital radiography system, which allowed vertebral width and optical density to b...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/FM.a2015.0068
更新日期：2016-01-01 00:00:00
abstract：:The present case report describes the topographical anatomy and radiological study of an asymmetrical inferior articular process of a lumbar vertebra, which was detected during routine osteology teaching of undergraduate medical students. The inferior articular process of the lumbar vertebra on the left side was rudim...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：:Goldenhar syndrome (GS) is a well-recognised condition characterised by variable degree of uni- or bilateral involvement of craniofacial structures involving first and second branchial arches manifesting ocular and auricular anomalies and also vertebral defect. This syndrome presents at birth and its exact aetiology i...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/fm.2013.0060
更新日期：2013-11-01 00:00:00
abstract：:Data for the force necessary to fracture the isolated calvaria (skull cap) are not available in the extant literature. Twenty dry adult calvaria were tested to failure quasistatically at the vertex using a 15-kN load cell. The forces necessary to fracture or cause diastasis of calvarial sutures were then documented an...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：:The inferior colliculus (IC) of the bank vole is made up of 3 nuclei: the external and pericentral nucleus, which are located on the outer border of the IC, and the central nucleus, which is the largest part of IC and shows a laminated structure. On the basis of various morphological criteria 5 types of neurons have b...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The main blood supply of the thalamus constitute internal branches of the posterior cerebral, posterior communicating, middle, and choroid arteries. Branches of these arteries from three groups of vessels: medial, lateral, and posterior. Considering the number of vessels, their diameter and direct origin from the cere...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Atherosclerotic occlusion of a coronary vessel is the commonest cause of ischaemic heart disease. The distribution of atherosclerotic lesions is not random,with stenoses preferentially situated at branch ostia, bifurcation points, and the proximal segments of daughter vessels. The aim of this study was to de...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：10.5603/fm.2013.0033
更新日期：2013-08-01 00:00:00
abstract：:Recurrent laryngeal nerve paralysis represents a major complication in oesophageal cancer surgery. Nerve-muscle transplantation to the paraglottic space after resection of the recurrent laryngeal nerve with the ansa cervicalis (AC) has recently become the procedure of choice. The aim of this study was to investigate t...
journal_title：Folia morphologica
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
