AgNOR, Ki-67 and PCNA expression in fibroepithelial tumours of the breast in correlation with morphological features.

Abstract:

:The authors retrospectively reviewed the cytological slides of 44 histopathologically confirmed fibroepithelial lesions of the breast, of which 11 were fibroadenoma (FA), 19 benign phyllodes tumours (PTLGM), 8 borderline (PTBM) and 6 malignant (PTHGM). The 2 FA misdiagnosed as PTLGM in cytological smears were both of cellular type. NORS were quantified in a series of the above cases using the silver-colloid method. Expression of Ki-67 and PCNA were evaluated by immunohistochemistry on sections from the corresponding paraffin blocks. The results were compared with morphological parameters. In phyllodes tumours (PT), the AgNOR scores showed a tendency to increase with degrees of malignancy. There was significant correlation between Ag- NOR counts and proliferation rates as determined by Ki-67 and PCNA immunostaining. Ki-67 and PCNA expression correlated with mitotic count, stromal overgrowth, cellularity and atypia in PT. Determination of the AgNOR number per cell revealed an overlap between FA and PTLGM. The proliferating activity determined by immunohistochemistry with Ki-67 and PCNA antibodies did not reveal any significant difference between FA and PTLGM. In summary, Ki-67 and PCNA expression is suggested as a marker of stromal element proliferation. The results obtained confirm the diagnostic difficulties in distinguishing PTLGM from FA of the cellular type using fine needle aspiration cytology.

journal_name

Folia Morphol (Warsz)

journal_title

Folia morphologica

authors

Barwijuk-Machała M,Musiatowicz B,Cylwik J,Reszeć J,Augustynowicz A

keywords:

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

133-5

issue

1

eissn

0015-5659

issn

1644-3284

journal_volume

63

pub_type

杂志文章
  • Anatomical and histological data on the ciliary ganglion in the Egyptian spiny mouse (Acomys cahirinus Desmarest).

    abstract::The morphology and topography of the ciliary ganglion in the Egyptian spiny mouse were studied with use of histochemical and histological techniques. The ciliary ganglion of the Egyptian spiny mouse consisted of between 3 and 4 agglomerations of nerve cells. The largest was situated at the point where the ventral bran...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Nowak E,Kuder T,Szczurkowski A,Kuchinka J

    更新日期:2004-08-01 00:00:00

  • Evaluation of the frequency of left renal vein variations in computed tomography and its relationship with cancer development.

    abstract:BACKGROUND:Left renal vein (LRV) variations occur in 0.8-10.2% of the population. The most common LRV variations are retroaortic left renal vein (RLRV) and circumaortic left renal vein (CLRV). The purpose of this study is to determine the frequency of LRV variations in a large series on computed tomography (CT) and to ...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2019.0137

    authors: Kuzan TY,Kuzan BN,Telli TA,Tüney D

    更新日期:2020-01-01 00:00:00

  • The atrioventricular and ventriculoatrial branches of the human coronary arteries in relation to the type of arterial vascularization.

    abstract::Studies were performed on 130 hearts removed from cadavers of adults of both sexes. The atrioventricular (A-V) and ventriculoatrial (V-A) branches are vessels which supply both the atrial and ventricular walls through the recurrent rami. A-V and A-V branches often form the superficial and deep networks in relation to ...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Krupa U

    更新日期:1994-01-01 00:00:00

  • Anatomy of sartorius muscle.

    abstract::A sartorius muscle is the longest muscle of the human system. It runs over 2 joints- hip and knee joints. In the study 10 sartorius muscles were examined. They were dissected free of lower human limbs. Dimensions of limbs which these muscles come from and dimensions of the muscles and their component parts were examin...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.2014.0037

    authors: Dziedzic D,Bogacka U,Ciszek B

    更新日期:2014-08-01 00:00:00

  • The distribution of ghrelin cells in the human and animal gastrointestinal tract: a review of the evidence.

    abstract::The growth hormone and appetite are regulated by a 28-peptide hormone called ghrelin, which is produced in the stomach, pituitary gland, and other body tissues. The physiological roles fulfilled by ghrelin include regulation of food intake, cardiac output, reproductive system, proliferation of cells, and formation of ...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2020.0077

    authors: Mehdar KM

    更新日期:2020-07-09 00:00:00

  • Anatomical variations of the abductor pollicis longus: a pilot study.

    abstract:BACKGROUND:The abductor pollicis longus (APL) originates from the lateral part of the dorsal surface of the body of the ulna below the insertion of the anconeus muscle, from the interosseous membrane, and from the middle third of the dorsal surface of the body of the radius. However, the number of its accessory bands a...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2019.0134

    authors: Karauda P,Olewnik Ł,Podgórski M,Polguj M,Ruzik K,Szewczyk B,Topol M

    更新日期:2020-01-01 00:00:00

  • The paranasal sinuses: three-dimensional reconstruction, photo-realistic imaging, and virtual endoscopy.

    abstract:BACKGROUND:The purpose of the study was to create computer-aided design models of the paranasal sinuses (frontal, maxillary, and sphenoid) and to perform virtual endoscopy (VE) to them by using virtual reality modelling language technique. MATERIALS AND METHODS:The visible human dataset was used as the input imaging d...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2016.0006

    authors: Kapakin S

    更新日期:2016-01-01 00:00:00

  • Diastema size and type of upper lip midline frenulum attachment.

    abstract:BACKGROUND:Diastema is a space between teeth. The most often is maxillary midline diastema between upper central incisors. One of the main causes of diastema is enlarged upper lip frenulum attachment. The aim of the study was to assess frenulum attachment in patients with diastema and investigate if type of upper lip f...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2016.0079

    authors: Sękowska A,Chałas R

    更新日期:2017-01-01 00:00:00

  • A cephalic vein drained into one of the double axillary veins through the pectoralis major muscle.

    abstract::Although the cephalic vein follows a fairly consistent course, numerous variants have been reported. We found a rare anatomical presentation of the cephalic vein in a 43-year-old Korean male cadaver. The cephalic vein had anastomosed with the basilic vein and brachial vein at the level of the elbow, perforated the pec...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2015.0082

    authors: Hong JE,Kim BR,Kim J,Yoon SP

    更新日期:2016-01-01 00:00:00

  • Anatomical eponyms - unloved names in medical terminology.

    abstract::Uniform international terminology is a fundamental issue of medicine. Names of various organs or structures have developed since early human history. The first proper anatomical books were written by Hippocrates, Aristotle and Galen. For this reason the modern terms originated from Latin or Greek. In a modern time the...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2016.0012

    authors: Burdan F,Dworzański W,Cendrowska-Pinkosz M,Burdan M,Dworzańska A

    更新日期:2016-01-01 00:00:00

  • Stress-induced changes in the aged-rat adrenal cortex. Histological and histomorphometric study.

    abstract:BACKGROUND:Stress exposure exerts direct effects on the morphology and functionality of the adrenal cortex. In addition, ageing effects growth, differentiation, apoptosis and cellularity of the cortex. The missing data is the combined effect of stress and ageing on the adrenal cortex. The aim of this study was to demon...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2018.0035

    authors: Zaki SM,Abdelgawad FA,El-Shaarawy EAA,Radwan RAK,Aboul-Hoda BE

    更新日期:2018-01-01 00:00:00

  • Gross anatomy of the intestine and its mesentery in the nutria (Myocastor coypus).

    abstract::The intestines and mesentery of the nutria (Myocastor coypus) have not been fully described. In the present study 30 adult nutrias were studied using gross dissection. The small intestine was divided into the duodenum, jejunum and ileum as usual. The duodenum started at the pylorus with a cranial portion, which dilate...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Pérez W,Lima M,Bielli A

    更新日期:2008-11-01 00:00:00

  • Substantia nigra hyperechogenicity in Polish patients with Parkinson's disease.

    abstract:BACKGROUND:Hyperechogenicity of the substantia nigra (SN) measured by transcranial sonography (TCS) is a characteristic feature observed in patients with Parkinson's disease (PD). To our knowledge, no SN hyperechogenicity data are available for Polish population. Moreover most of studies come from few centres, which us...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.2014.0042

    authors: Ambrosius W,Michalak S,Owecki M,Łukasik M,Florczak-Wyspiańska J,Kozubski W

    更新日期:2014-08-01 00:00:00

  • An artery accompanying the sciatic nerve (arteria comitans nervi ischiadici) and the position of the hip joint: a comparative histological study using chick, mouse, and human foetal specimens.

    abstract::Birds and reptiles always carry a long and thick artery accompanying the sciatic nerve (i.e., the sciatic artery), whereas mammals do not. We attempted to demonstrate a difference in courses of the nerve and artery in fetuses in relation with the hip joint posture. Eight mid-term human fetuses (15-18 weeks), five mous...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/fm.2013.0007

    authors: Ishizawa A,Hayashi S,Nasu H,Abe H,Rodríguez-Vázquez JF,Murakami G

    更新日期:2013-02-01 00:00:00

  • Variations in the squamous part of the occipital bone in medieval and contemporary cranial series from Bulgaria.

    abstract::The squamous part of the occipital bone is a place of many different variations. They are a result of faulty ossification in the occipital squama or due to the presence of sutural bones in the lambda region. As their differentiation is intricate because of the various criteria used, the issue of their recognition in t...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.2014.0055

    authors: Nikolova S,Toneva D,Yordanov Y,Lazarov N

    更新日期:2014-11-01 00:00:00

  • An unusual muscular variation of the infratemporal fossa.

    abstract::The infratemporal fossa is often the site of pathology or surgical intervention. We describe an unusual muscle found during the routine dissection of the right infratemporal fossa. The literature germane to this variable muscle, best described as a variant of the pterygoideus proprius, is reviewed. The clinician may c...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Tubbs RS,Stetler W,Shoja MM,Loukas M,Salter EG,Oakes WJ

    更新日期:2007-08-01 00:00:00

  • Morphological classification of the septomarginal trabecula in humans.

    abstract::Although the septomarginal trabecula is a well-known anatomical structure, there continue to be different ways of studying it. In this study, we dissected the muscle bundles that form it, and this has enabled us to present a new classification based on the origin, path, and termination of these bundles. This study was...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Bandeira ST,Wafae GC,Ruiz C,Nascimento SR,Fernandes JR,Wafae N

    更新日期:2011-11-01 00:00:00

  • Histological studies of selected organs of mice experimentally infected with Acanthamoeba spp.

    abstract::Histological studies of the brain, lungs, liver, kidneys, heart, and the spleen were carried out in mice previously infected with 6 pathogenic strains of free-living amoebae of the genus Acanthamoeba. The potential virulence of the strains studied was determined on the basis of re-isolation of the amoebae from the org...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Górnik K,Kuźna-Grygiel W

    更新日期:2005-08-01 00:00:00

  • Effects of diet and fluoride on early phases of odontogenesis in rats.

    abstract::The influence of diet and fluoride on odontogenesis in rats was investigated. 20 foetuses, 20 days old, were divided into four groups. The control group was fed with the standard diet and drank water with 0.16 mg F/l. The second, third and fourth groups were fed with the deficit, experimental diet and drank distilled ...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Maciejewska I,Adamowicz-Klepalska B

    更新日期:2000-01-01 00:00:00

  • Preliminary immunohistochemical investigations of thyroid C cells in an experimental model of hyperthyroidism.

    abstract::The role of the parafollicular (C) cells, the second most important cells in the thyroid gland, has not hitherto been clarified. They are considered to be disperse neuroendocrine cells of the APUD system and synthesise and release many of the regulatory peptides. Few publications are concerned with the evaluation of t...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Dadan J,Zbucki R RŁ,Sawicki B,Bialuk I,Zawadzka A,Winnicka MM,Puchalski Z

    更新日期:2003-11-01 00:00:00

  • The sphenopalatine foramen in man: anatomical, radiological and endoscopic study.

    abstract:BACKGROUND:Epistaxis is a frequent problem otorhinolaryngologists faces of in their practice. The variations of the sphenopalatine foramen (SPF) and consequ-ently the artery may be one of the major sources of such bleeding. The present work aimed to localise the site of SPF and also to illustrate its different shapes, ...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2017.0104

    authors: El-Shaarawy EAA,Hassan SS

    更新日期:2018-01-01 00:00:00

  • On a rare form of fenestration of the middle cerebral artery.

    abstract::A rare case of fenestration of the left middle cerebral artery (MCA) is presented. There is a coexistence with hypoplasia of precommunicans part of the right posterior cerebral artery and its "fetal" branching from internal carotid artery. This form of variation may cause mistakes during interpretation of angiographic...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Ciszek B

    更新日期:1995-01-01 00:00:00

  • Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane.

    abstract:BACKGROUND:Nicotine is associated with increased incidence of periodontal disease and poor response to therapy. This article aimed at identifying the expression of matrix metalloproteinases 2 (MMPs2) and vascular endothelial growth factor (VEGF) proteins on extracellular matrix, fibrous distribution and angiogenetic de...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2018.0004

    authors: Deveci B,Ayna B,Tacir IH,Deveci E,Tuncer MC,Pala A

    更新日期:2018-01-01 00:00:00

  • Large skin arteries of the leg and foot in man.

    abstract::The anatomical method with Computer Digital Image Analysis system served to examine large skin arteries of the crus and the foot in 152 human specimens. Their sources were: 1. popliteal artery (rr. gastrocnemii:medialis--62.89%, lateralis--78.95%), 2. anterior tibial artery (a. peronealis lateralis superior--97.37%, a...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Szpinda M,Molski S,Grabowska-Gaweł A

    更新日期:2000-01-01 00:00:00

  • Asymmetry of the ovale and spinous foramina in mediaeval and contemporary skulls in radiological examinations.

    abstract::The aim of this work was to evaluate the morphology and asymmetry of the ovale and spinous foramina. Examinations were carried out on 102 mediaeval and 85 contemporary male skulls. In both groups there predominated individuals who had died at mature (maturus) and adult (adultus) age. Radiological images in occipital p...

    journal_title:Folia morphologica

    pub_type: 历史文章,杂志文章

    doi:

    authors: Teul I,Czerwiński F,Gawlikowska A,Konstanty-Kurkiewicz V,Sławiński G

    更新日期:2002-01-01 00:00:00

  • The influence of experimental Bacteroides fragilis infection on substance P and somatostatin-immunoreactive neural elements in the porcine ascending colon - a preliminary report.

    abstract::The present study was aimed at disclosing the influence of Bacteroides fragilis (one of the most important bacterial agents causing colitis in children) experimental infection on the expression of substance P (SP) and somatostatin (SOM) in neurons and nerve fibres within the porcine ascending colon. Distinct differenc...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Gonkowski S,Kamińska B,Bossowska A,Korzon M,Landowski P,Majewski M

    更新日期:2003-11-01 00:00:00

  • Comparison of color difference formulas to best distinguish resected areas of malignant brain tumors from their background using 5-aminolevulinic acid fluorescence.

    abstract:BACKGROUND:Fluorescence-guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) his proven to assist neurosurgeons to achieve a more complete brain tumour resection. However, 5-ALA-guided surgery is limited since it is often difficult to distinguish the colour difference between the resected areas of malignant brain tu...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2020.0035

    authors: Szmuda T,Ali S,Słoniewski P

    更新日期:2020-03-24 00:00:00

  • Estimation of Purkinje cell quantification and volumetry in the cerebellum using a stereological technique.

    abstract::Systematic sampling using the Cavalier's principle provides accurate, efficient, cheap, and simple quantitative estimates of objects within neuroanatomical structures like the cerebellum. We identified and isolated the Purkinje cell layer and used this information to extrapolate the stereological technique to estimate...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:

    authors: Akosman MS,Gocmen-Mas N,Karabekir HS

    更新日期:2011-11-01 00:00:00

  • Location of the narrowest area of the pharynx regarding body mass index and obstructive sleep apnoea severity.

    abstract:BACKGROUND:Among authors studying morphological determinants of the obstructive sleep apnoea (OSA) controversies exist on the location of the narrowest area within the pharynx, critical for development of obstruction. Those disagreements primarily revolve around differences between obese and nonobese OSA patients. Dete...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2017.0018

    authors: Krasny M,Wysocki J,Prus M,Niemczyk K

    更新日期:2017-01-01 00:00:00

  • Morphometric analysis and three-dimensional computed tomography reconstruction of the long bones of femoral and crural regions in Van cats.

    abstract:BACKGROUND:This study was conducted to determine the morphometric features and to make the three-dimensional (3D) reconstruction of the images obtained by computed tomography (CT) of the main long bones (femur, tibia, fibula) in Van cats, and to reveal the biometric differences between these measurement values of both ...

    journal_title:Folia morphologica

    pub_type: 杂志文章

    doi:10.5603/FM.a2020.0116

    authors: Yilmaz O,Demircioğlu İ

    更新日期:2020-09-23 00:00:00