On and off: proteasome and TGF-beta signaling.

abstract：:Transcription factors belonging to the basic helix-loop-helix Per-Arnt-Sim (bHLH/PAS) family control a wide variety of biological processes in mammalian and/or Drosophila. We have previously isolated bHLH/PAS Xenopus amphibian homologs of Single-minded (xSim) and aryl receptor nuclear translocator (xArnt) and characte...

journal_title：Experimental cell research

authors： Coumailleau P,Bollérot K,Lecomte C,Angelier N

更新日期：2003-07-15 00:00:00

abstract：:The effects of methylmercury (MeHg) on cytoplasmic microtubules in cultured fibroblasts and on the in vitro polymerization of microtubules were examined. MeHg caused disruption of cellular microtubules in a concentration- and time-dependent manner. Addition of the metal-chelating agent, dimercaptosuccinic acid (DMSA),...

journal_title：Experimental cell research

authors： Sager PR,Doherty RA,Olmsted JB

更新日期：1983-06-01 00:00:00

abstract：:Rat pheochromocytoma cells, PC12 cells, undergo differentiation in response to nerve growth factor (NGF). Although the Ras-MAP kinase signaling pathway has been shown to play a central role in the response to NGF, the precise mechanism which induces differentiation remains unclarified. Recently, several gamma-lactam-r...

journal_title：Experimental cell research

authors： Yao R,Osada H

更新日期：1997-08-01 00:00:00

abstract：:In preceding studies, the IP3-sensitive Ca2+ store of the hamster insulinoma cell line, HIT, was detected in cell surface protrusions such as microvilli and related membrane structures [Lange, K., and Brandt, U. (1993) FEBS Lett. 320, 183-188; and (1993) FEBS Lett. 325, 205-209]. In this study, these experiments were ...

journal_title：Experimental cell research

authors： Lange J,Schlieps K,Lange K,Brandt U,Knoll-Köhler E

更新日期：1996-11-01 00:00:00

abstract：:Filamin is a well-characterized actin-associated protein first isolated from chicken smooth muscle. Subsequently, this polypeptide and its nonmuscle homolog actin-binding protein have been shown to be expressed in avian muscle tissue, mammalian smooth muscle, mammalian macrophages and other blood cell types, as well a...

journal_title：Experimental cell research

authors： Brown KD,Binder LI

更新日期：1993-12-01 00:00:00

abstract：:Fluorescence photobleaching recovery has been employed to study the lateral mobility of the Sendai virus envelope glycoproteins (HN, neuraminidase/hemagglutinin protein (HN) fusion protein (F) on the surface of human erythrocytes. Our results indicate that the two viral glycoproteins are laterally immobile on the cell...

journal_title：Experimental cell research

authors： Henis YI,Gutman O,Loyter A

更新日期：1985-10-01 00:00:00

abstract：:In order to explore the potential value of Chinese hamster ovary (CHO) cells for the isolation of peroxisomal mutants defective in the peroxisomal fatty acid oxidation system, some characteristics of their peroxisomes were studied. Catalase was detected biochemically and histochemically in peroxisome-like particles in...

journal_title：Experimental cell research

authors： Santos MJ,Garrido J,Oliver C,Robbins AR,Leighton F

更新日期：1985-11-01 00:00:00

abstract：:The ATP/P2X7 axis of dendritic cells (DCs) mediates the activation of NLRP3 inflammasome and promotes secretion of interleukin (IL)-1β and IL-18 to induce T helper (Th) 2, Th17 differentiation in the pathogenesis of asthma. NLRP3 inflammasome also regulates high mobility protein 1 (HMGB1) release in DCs. Recent studie...

journal_title：Experimental cell research

authors： Li R,Wang J,Li R,Zhu F,Xu W,Zha G,He G,Cao H,Wang Y,Yang J

更新日期：2018-05-01 00:00:00

abstract：:A single cell of wild-type Dictyostelium discoideum forms a visible colony on a plastic dish in several days, but due to enhanced cell migration, amiB-null mutant cells scatter over a large area and do not form noticeable colonies. Here, with an aim to identify genes involved in cell migration, we isolated suppresser ...

journal_title：Experimental cell research

authors： Nagasaki A,Uyeda TQ

更新日期：2008-03-10 00:00:00

abstract：:Repeated injury to the stratum corneum of mammalian skin (caused by friction, soaps, or organic solvents) elicits hyperkeratosis and epidermal thickening. Functionally, these changes serve to restore the cutaneous barrier and protect the organism. To better understand the molecular and cellular basis of this response,...

journal_title：Experimental cell research

authors： Ajani G,Sato N,Mack JA,Maytin EV

更新日期：2007-08-15 00:00:00

abstract：:Gold nanoparticles are recently having much attention because of their increased applications in biomedical fields. In this paper, we demonstrated the photothermal efficacy of citrate capped gold nanoparticles (AuNPs) for the destruction of A431 cancer cells. Citrate capped AuNPs were synthesized successfully and char...

journal_title：Experimental cell research

authors： Raji V,Kumar J,Rejiya CS,Vibin M,Shenoi VN,Abraham A

更新日期：2011-08-15 00:00:00

abstract：:In addition to previously isolated ratjadone A we describe three new members of this family, ratjadones B, C, and D, from another strain of the myxobacterium Sorangium cellulosum. We have investigated the properties of these ratjadones with respect to their activity on mammalian cell lines. We found IC(50) values in t...

journal_title：Experimental cell research

authors： Köster M,Lykke-Andersen S,Elnakady YA,Gerth K,Washausen P,Höfle G,Sasse F,Kjems J,Hauser H

更新日期：2003-06-10 00:00:00

abstract：:Migration-stimulating factor (MSF), an oncofetal truncated isoform of fibronectin, is a potent stimulator of cell invasion. However, its distribution and motogenic role in non-small cell lung cancer (NSCLC) have never been identified. In this study, real-time PCR and immunohistochemical staining (IHC) were performed t...

journal_title：Experimental cell research

authors： Deng X,Ma Q,Zhang B,Jiang H,Zhang Z,Wang Y

更新日期：2013-10-15 00:00:00

abstract：:Cell-to-cell communication is essential for the development and maintenance of multicellular organisms. The tunneling nanotube (TNT) is a recently recognized distinct type of intercellular communication device. TNTs are thin protrusions of the plasma membrane and allow direct physical connections of the plasma membran...

journal_title：Experimental cell research

authors： Kimura S,Hase K,Ohno H

更新日期：2012-08-15 00:00:00

abstract：:Rap1 signaling is important for both major processes of vessel formation: vasculogenesis, or de novo vessel formation, and angiogenesis, sprouting of new vessels from pre-existing ones. We provide an overview of genetic studies in mice and zebrafish and discuss some of the proposed underlying mechanisms derived from c...

journal_title：Experimental cell research

authors： Chrzanowska-Wodnicka M

更新日期：2013-09-10 00:00:00

abstract：:Normal and transformed human cells when stained for ezrin, an F-actin-binding ERM (ezrin/radixin/moesin) family protein, revealed a faint and intense immunofluorescence, respectively. Surprisingly, nuclear staining that was assigned to the nucleolus by confocal laser and immunoelectron microscopy was detected in both ...

journal_title：Experimental cell research

authors： Kaul SC,Kawai R,Nomura H,Mitsui Y,Reddel RR,Wadhwa R

更新日期：1999-07-10 00:00:00

abstract：:We report the isolation of six cell lines (designated EB cell lines) from cultures of the hypoxanthine guanine phosphoribosyl transferase-deficient (HGPRT-) feeder-dependent embryonal carcinoma cell line PSA4TG12 which have undergone in vitro differentiation, and of clonal derivatives of these lines. Whereas some line...

journal_title：Experimental cell research

authors： Morgan RH,Henry JA,Hooper ML

更新日期：1983-10-15 00:00:00

abstract：:Nuclear-envelope nucleoside triphosphatase activity (NTPase), an enzymatic activity thought to participate in RNA transport, was localized in rat liver in situ after brief perfusion with 3% paraformaldehyde. Reaction product was distributed along the nucleoplasmic side of the nuclear envelope (NE) in heterochromatin, ...

journal_title：Experimental cell research

authors： Clawson GA,Friend DS,Smuckler EA

更新日期：1984-11-01 00:00:00

abstract：:Nuclear and territorial positioning of p- and q-telomeres and centromeres of chromosomes 3, 8, 9, 13, and 19 were studied by repeated fluorescence in situ hybridization, high-resolution cytometry, and three-dimensional image analysis in human blood lymphocytes before and after stimulation. Telomeres were found on the ...

journal_title：Experimental cell research

authors： Amrichová J,Lukásová E,Kozubek S,Kozubek M

更新日期：2003-09-10 00:00:00

abstract：:We have studied the use of electrofusion to obtain hybridomas producing antigen-specific antibodies after immunization of murine lymphocytes in vitro. Under optimal conditions fusion frequencies of the order of magnitude of 10(-3) were obtained, which is approximately 80-fold higher than the mean value obtained with f...

journal_title：Experimental cell research

authors： van Duijn G,Langedijk JP,de Boer M,Tager JM

更新日期：1989-08-01 00:00:00

abstract：:Transfection of primary rat keratinocytes with the polyomavirus large T gene promotes the establishment of cell lines. The keratinocytes express the large T protein and can be continuously cultured in medium containing a low concentration of calcium. The immortalized keratinocytes retain the ability to differentiate w...

journal_title：Experimental cell research

authors： Bayley SA,Stones AJ,Smith CG

更新日期：1988-07-01 00:00:00

abstract：:Identification of transcription factors expressed by differentiated cells is informative not only of tissue-specific pathways, but to help identify master regulators for cellular reprogramming. If applied, such an approach could generate healthy autologous tissue-specific cells for clinical use where cells from the ho...

journal_title：Experimental cell research

authors： Hustler A,Eardley I,Hinley J,Pearson J,Wezel F,Radvanyi F,Baker SC,Southgate J

更新日期：2018-08-15 00:00:00

abstract：:Implantation of myoblasts is a strategy used to enhance the regeneration of skeletal muscle tissue in vivo. In mouse models, myogenic cell lines and primary cells have been employed with different yields of adult muscle tissue formed. The present work is a study of some developmental features of expanded primary mouse...

journal_title：Experimental cell research

authors： Lorenzon P,Bernareggi A,Degasperi V,Nurowska E,Wernig A,Ruzzier F

更新日期：2002-08-01 00:00:00

abstract：:Scavenger receptor class A (SR-A) facilitates the development of atherosclerosis, which might be due to its role in the uptake of modified low-density lipoproteins. However, the receptor is also suggested to be important for cell adhesion, thereby potentially influencing the residence time of cells in vivo. Using SR-A...

journal_title：Experimental cell research

authors： van Velzen AG,Suzuki H,Kodama T,van Berkel TJ

更新日期：1999-07-10 00:00:00

abstract：:It has been reported that cholesterol-lowing agents can ameliorate severity of myocarditis. However, the beneficial effect of the agents has been claimed to be independent of cholesterol reduction as there is no significant change in the plasma cholesterol level in myocarditis. In the present study, using experimental...

journal_title：Experimental cell research

authors： Chang H,Wang Y,Wu Y,Ma P,Song Y,Liu C,Ye Y,Qi JH,Qi Z

更新日期：2020-10-01 00:00:00

abstract：:Mdg1/ERdj4, a mammalian chaperone that belongs to the HSP40 protein family, has been reported to be located in the endoplasmic reticulum (ER), is induced by ER stress, and protects ER stressed cells from apoptosis. Here we show that under normal physiological conditions, Mdg1/ERdj4 is expressed at various levels in th...

journal_title：Experimental cell research

authors： Berger BJ,Müller TS,Buschmann IR,Peters K,Kirsch M,Christ B,Pröls F

更新日期：2003-10-15 00:00:00

abstract：:We have compared dye coupling in pairs of small (less than 10 microns in diameter) and large (greater than 20 microns in diameter) keratinocytes isolated from normal human epidermis, using Lucifer yellow microinjection. Under control conditions, dye coupling was found in only 1 out of the 25 small pairs tested, wherea...

journal_title：Experimental cell research

authors： Salomon D,Chanson M,Vischer S,Masgrau E,Vozzi C,Saurat JH,Spray DC,Meda P

更新日期：1992-08-01 00:00:00

abstract：:Long-term biological effects of epidermal growth factor (EGF), insulin, insulin-like growth factor-I (IGF-I), and transforming growth factor-beta (TGF-beta) were examined with human epidermoid carcinoma KB cells. EGF inhibited the growth of KB cells in both serum-containing and serum-free synthetic media by reducing t...

journal_title：Experimental cell research

authors： Koyasu S,Kadowaki T,Nishida E,Tobe K,Abe E,Kasuga M,Sakai H,Yahara I

更新日期：1988-05-01 00:00:00

abstract：:Oxysterol-binding protein (OSBP)-related proteins (ORPs) are conserved lipid binding proteins found in organisms ranging from yeast to mammals. Recent findings have indicated that these proteins mainly localize to contact sites of 2 different membranous organelles. ORP6, a member of the ORP subfamily III, is one of th...

journal_title：Experimental cell research

authors： Mochizuki S,Miki H,Zhou R,Kido Y,Nishimura W,Kikuchi M,Noda Y

更新日期：2018-09-15 00:00:00

abstract：:The effect of 1 microM antimycin on the proliferative properties, metabolism and basic cell composition of Ehrlich ascites tumour cells cultured in the second in vitro passage was studied. Continuous drug exposure of asynchronous cells caused rapid cessation of cell growth, characterized by the cell number and DNA, RN...

journal_title：Experimental cell research

authors： Löffler M

更新日期：1985-03-01 00:00:00