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Localization of nucleoside triphosphatase activity to the inner nuclear envelope and associated heterochromatin.

Abstract：

:Nuclear-envelope nucleoside triphosphatase activity (NTPase), an enzymatic activity thought to participate in RNA transport, was localized in rat liver in situ after brief perfusion with 3% paraformaldehyde. Reaction product was distributed along the nucleoplasmic side of the nuclear envelope (NE) in heterochromatin, was only occasionally found at nuclear pores, and nuclear deposition was selectively blocked by inhibitors of NE NTPase activity. Our results suggest that NTPases, which are active in the NE and which participate in RNA transport, are not specifically associated with nuclear-pore complexes.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Clawson GA,Friend DS,Smuckler EA

doi

10.1016/0014-4827(84)90796-1

subject

Has Abstract

pub_date

1984-11-01 00:00:00

pages

310-4

issue

1

eissn

0014-4827

issn

1090-2422

pii

0014-4827(84)90796-1

journal_volume

155

pub_type

杂志文章

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