Dissociation between prostaglandin levels and blood flow to the retina and choroid in the newborn pig after nonsteroidal antiinflammatory drugs.

abstract：PURPOSE:The purpose of this study was to identify a new Pseudomonas protease and determine its possible role in keratitis. METHODS:Concentrated culture supernatants of the Pseudomonas aeruginosa strains PA103 and ATCC 19660 were analyzed by zymography. P. aeruginosa small protease (PASP) was purified from strain PA103...

journal_title：Investigative ophthalmology & visual science

authors： Marquart ME,Caballero AR,Chomnawang M,Thibodeaux BA,Twining SS,O'Callaghan RJ

更新日期：2005-10-01 00:00:00

abstract：Purpose:Understanding the role of mitochondria in retinal ganglion cells (RGCs) is relevant to human disease as studies have shown mitochondrial abnormalities in primary open-angle glaucoma patients. This study seeks to determine the effects of the sigma-1 receptor (σ-1r) and its agonists on mitochondrial function in o...

journal_title：Investigative ophthalmology & visual science

authors： Ellis DZ,Li L,Park Y,He S,Mueller B,Yorio T

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Retinopathy of prematurity (ROP) is a major problem among very preterm survivors of neonatal intensive care. Neovascularization of the retina is prominent in the proliferative stages of ROP and is under the control of several factors such as vascular endothelial growth factor (VEGF). This study was undertaken o...

journal_title：Investigative ophthalmology & visual science

authors： Cooke RW,Drury JA,Mountford R,Clark D

更新日期：2004-06-01 00:00:00

abstract：:The secretion of the aqueous humor has been proposed to occur as the result of active Na+ transport by a ouabain-sensitive Na-K ATPase. We have examined the localization of this enzyme in the epithelium of rabbit ciliary body pars plicata using [3H]ouabain autoradiography. Single ciliary processes were isolated and in...

journal_title：Investigative ophthalmology & visual science

authors： Usukura J,Fain GL,Bok D

更新日期：1988-04-01 00:00:00

abstract：Purpose:Synthesis of keratan sulfate (KS) relies on coordinated action of multiple enzymes, including the N-acetylglucosamine-transferring enzyme, β-1,3-N-acetylglucosaminyltransferase-7 (β3GnT7). A mouse model deficient in β3GnT7 was developed to explore structural changes in KS and the extracellular matrix (ECM; i.e....

journal_title：Investigative ophthalmology & visual science

authors： Littlechild SL,Young RD,Caterson B,Yoshida H,Yamazaki M,Sakimura K,Quantock AJ,Akama TO

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To compare two spectral domain optical coherence tomography (SD-OCT) devices for the identification of angle structures and the presence of angle closure. METHODS:This was a prospective comparative study. Consecutive patients underwent gonioscopy and anterior segment imaging using two SD-OCT devices (iVue and ...

journal_title：Investigative ophthalmology & visual science

authors： Quek DT,Narayanaswamy AK,Tun TA,Htoon HM,Baskaran M,Perera SA,Aung T

更新日期：2012-08-03 00:00:00

abstract：PURPOSE:To develop an imaging technique that maps the distribution of free cystine in the rat lens at subcellular resolution and enables cystine accumulation to be compared with the expression of the cystine-glutamate exchanger (Xc-). METHODS:Whole lenses were fixed, cryoprotected, and then cryosectioned in either an ...

journal_title：Investigative ophthalmology & visual science

authors： Li L,Lim J,Jacobs MD,Kistler J,Donaldson PJ

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To examine the extent to which the two major determinants of refractive error, corneal curvature and axial length, are scaled relative to one another by shared genetic variants, along with their relationship to the genetic scaling of height. METHODS:Corneal curvature, axial length, and height were measured in ...

journal_title：Investigative ophthalmology & visual science

authors： Guggenheim JA,Zhou X,Evans DM,Timpson NJ,McMahon G,Kemp JP,St Pourcain B,Northstone K,Ring SM,Fan Q,Wong TY,Cheng CY,Khor CC,Aung T,Saw SM,Williams C

更新日期：2013-03-07 00:00:00

abstract：PURPOSE:To examine the involvement of p27(KIP1) in the regulation of the proliferation of the developing corneal endothelium. METHODS:Central and peripheral corneas in C57Bl6 mice at postnatal day (P)1, P11, and 12 weeks after birth were analyzed by immunocytochemistry with anti-p27(KIP1), -p57(KIP2), and -proliferati...

journal_title：Investigative ophthalmology & visual science

authors： Yoshida K,Kase S,Nakayama K,Nagahama H,Harada T,Ikeda H,Harada C,Imaki J,Ohgami K,Shiratori K,Ilieva IB,Ohno S,Nishi S,Nakayama KI

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:We showed previously that single nucleotide polymorphism (SNP) rs662702 in PAX6 may be located in a microRNA-328 binding site that causes susceptibility to high myopia. Our study was done to elucidate the role of PAX6 and its relationship with microRNA-328 in myopia. METHODS:A luciferase assay was used to conf...

journal_title：Investigative ophthalmology & visual science

authors： Chen KC,Hsi E,Hu CY,Chou WW,Liang CL,Juo SH

更新日期：2012-05-31 00:00:00

abstract：:PURPOSE. To investigate the effects and possible mechanisms of rat bone marrow mesenchymal stem cell (BMSC) transplantation on the light-damaged retinal structure and the apoptosis of photoreceptors. METHODS. DAPI-labeled BMSCs were transplanted into the subretinal space of light-damaged Sprague-Dawley rats 10 days af...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Wang W

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To examine immune processes in the lacrimal gland of patients with chronic graft-versus-host disease (cGVHD) by evaluating the expression of surface molecules associated with T-cell activation. METHODS:Antibodies to CD4, CD8, CD34, CD40, CD54, CD80, CD86, CD154, and HLA-DR were used for immunohistochemical ana...

journal_title：Investigative ophthalmology & visual science

authors： Ogawa Y,Kuwana M,Yamazaki K,Mashima Y,Yamada M,Mori T,Okamoto S,Oguchi Y,Kawakami Y

更新日期：2003-05-01 00:00:00

abstract：:The color matches of 46 retinitis pigmentosa (RP) patients were found to differ significantly from those of 55 unaffected observers. The color matches of group I (trichromatic) RP observers were more protanomalous (i.e., required a greater red/green mixture ratio) than those of unaffected observers. The matches of gro...

journal_title：Investigative ophthalmology & visual science

authors： Young RS,Fishman GA

更新日期：1980-08-01 00:00:00

abstract：Purpose:The three-dimensional configurations of rod and cone bipolar cell (BC) dendrites and horizontal cell (HC) processes outside rod and cone synaptic terminals have not been fully elucidated. We reveal how these neurites are mutually arranged to coordinate formation and maintenance of the postsynaptic complex of ri...

journal_title：Investigative ophthalmology & visual science

authors： Tsukamoto Y,Iseki K,Omi N

更新日期：2021-01-04 00:00:00

abstract：PURPOSE:The virulence of any given strain of herpes simplex virus (HSV) is probably due to the effects of the constellation of genes in that strain and how they act in concert to promote disease. The goal of this work was to develop a system to identify and study the role of multiple genes in HSV disease. METHODS:Mixe...

journal_title：Investigative ophthalmology & visual science

authors： Brandt CR,Kolb AW,Shah DD,Pumfery AM,Kintner RL,Jaehnig E,Van Gompel JJ

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:Retinal nerve fiber (RNFL) thickness and visual field loss data from patients with glaucoma were analyzed in the context of a model, to better understand individual variation in structure versus function. METHODS:Optical coherence tomography (OCT) RNFL thickness and standard automated perimetry (SAP) visual fi...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Anderson SC,Wall M,Raza AS,Kardon RH

更新日期：2009-09-01 00:00:00

abstract：Purpose:Conjunctival squamous cell carcinoma (SCC), a type of ocular surface neoplasia, is primarily treated by surgical resection and topical immuno- or chemotherapy. Metastatic disease may be treated with systemic chemo- or immunotherapy, albeit with variable response. The purpose of this study was to determine wheth...

journal_title：Investigative ophthalmology & visual science

authors： Nagarajan P,El-Hadad C,Gruschkus SK,Ning J,Hudgens CW,Sagiv O,Gross N,Tetzlaff MT,Esmaeli B

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To describe and interpret "choroidal caverns," an unreported optical coherence tomography (OCT) finding in the choroid of patients with geographic atrophy (GA) secondary to atrophic AMD. METHODS:Retrospective analysis of patients with GA. Main outcomes measures included estimation of the prevalence of choroida...

journal_title：Investigative ophthalmology & visual science

authors： Querques G,Costanzo E,Miere A,Capuano V,Souied EH

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:We investigated the response of retinal vessel diameters and oxygen saturation to flicker light stimulation of neuronal activity in patients with diabetic retinopathy. METHODS:We included 18 patients with nonproliferative diabetic retinopathy (mean age 62.2 ± 8.3 years, diabetes type 1 in 4 patients and type 2...

journal_title：Investigative ophthalmology & visual science

authors： Hammer M,Heller T,Jentsch S,Dawczynski J,Schweitzer D,Peters S,Schmidtke KU,Müller UA

更新日期：2012-06-26 00:00:00

abstract：:The mitotic rate and goblet cell content of conjunctival epithelium following total or central corneal epithelial removal using n-heptanol was measured to determine how the conjunctival epithelium responds to injury and whether conjuctiva responds to central corneal epithelial loss. One day following a wound that remo...

journal_title：Investigative ophthalmology & visual science

authors： Danjo S,Friend J,Thoft RA

更新日期：1987-09-01 00:00:00

abstract：PURPOSE:To characterize retinal autoantigens in patients with cancer-associated retinopathy (CAR). METHODS:The sera of 4 patients with CAR were examined by western blot analysis, and the proteins specifically probed were partially purified from bovine retinas and identified by Edman sequence analysis of the proteolyti...

journal_title：Investigative ophthalmology & visual science

authors： Ohguro H,Ogawa K,Nakagawa T

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:The efficacy of the peptide Ac-EEED on reducing cell adhesion and proliferation in vitro and choroidal neovascularization (CNV) in vivo was examined. METHODS:The peptide chimera containing the Ac-EEED sequence was chemically linked to the N terminus of the XMTM delivery peptide from the E(rns) viral surface pr...

journal_title：Investigative ophthalmology & visual science

authors： Caballero S,Yang R,Grant MB,Chaqour B

更新日期：2011-04-16 00:00:00

abstract：PURPOSE:To investigate the patterns of retinal nerve fiber layer (RNFL) defects in mean deviation-matched early glaucomatous eyes with either superior or inferior visual hemifield loss. METHODS:Seventy-five open-angle glaucoma patients with isolated parafoveal scotoma (PFS) within a central 10° of fixation, and 62 pat...

journal_title：Investigative ophthalmology & visual science

authors： Choi JA,Park HY,Jung KI,Hong KH,Park CK

更新日期：2013-10-23 00:00:00

abstract：:Cellular retinol binding protein (CRBP) was localized in the rat retina by means of light and electron microscopic immunocytochemistry. The peroxidase-antiperoxidase (PAP) method employed at the light microscopic level showed that CRBP is sharply localized to the retinal pigment epithelium (RPE). None was detectable i...

journal_title：Investigative ophthalmology & visual science

authors： Bok D,Ong DE,Chytil F

更新日期：1984-08-01 00:00:00

abstract：Purpose:The purpose of this study was to clarify the interactions between macrophages (MPs) and RPE cells in coculture systems to investigate the functional plasticity of RPE cells. Methods:Adherent peritoneal cells or murine MP cell line Raw 264.7 was cocultured with primary RPE cells taken from C57BL/6 mice, with or...

journal_title：Investigative ophthalmology & visual science

authors： Yamawaki T,Ito E,Mukai A,Ueno M,Yamada J,Sotozono C,Kinoshita S,Hamuro J

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To establish, using adaptive optics scanning laser ophthalmoscopy (AOSLO), that the retinal parafoveal capillary network is altered before the onset of diabetic retinopathy in adult patients with type 2 diabetes. METHODS:AOSLO videos were acquired in the parafoveal region of one eye from control subjects and f...

journal_title：Investigative ophthalmology & visual science

authors： Tam J,Dhamdhere KP,Tiruveedhula P,Manzanera S,Barez S,Bearse MA Jr,Adams AJ,Roorda A

更新日期：2011-11-29 00:00:00

abstract：PURPOSE:To investigate the involvement of the p38 mitogen-activated protein (MAP) kinase and phosphatidylinositol-3 (PI-3) kinase-Akt signaling pathways after pathologic stimulation by N-methyl-D-aspartate (NMDA) receptors of retinal neurons in vivo. METHODS:NMDA (2-200 nmol), SB203580 (0.2-10 nmol, an inhibitor of p3...

journal_title：Investigative ophthalmology & visual science

authors： Manabe S,Lipton SA

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine the relationship between objectively measured ambient light exposure and longitudinal changes in axial eye growth in childhood. METHODS:A total of 101 children (41 myopes and 60 nonmyopes), 10 to 15 years of age participated in this prospective longitudinal observationa...

journal_title：Investigative ophthalmology & visual science

authors： Read SA,Collins MJ,Vincent SJ

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To evaluate the physiological characteristics of the macula in patients with Vogt-Koyanagi-Harada disease during the convalescent stage with specific reference to the kinetics of foveal cone photopigment regeneration. METHODS:Six eyes of three patients at the convalescent stage of Vogt-Koyanagi-Harada disease ...

journal_title：Investigative ophthalmology & visual science

authors： Okamoto Y,Miyake Y,Horio N,Takakuwa H,Yamamoto E,Terasaki H

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To assess cross-sectional and longitudinal associations between exposure to Chlamydia pneumoniae infection and age-related macular degeneration (AMD) in the nested case-control sample drawn from the Blue Mountains Eye Study (BMES) cohort. METHODS:The BMES examined 3654 persons aged 49 to 97 years during 1992 t...

journal_title：Investigative ophthalmology & visual science

authors： Robman L,Mahdi OS,Wang JJ,Burlutsky G,Mitchell P,Byrne G,Guymer R,Taylor H

更新日期：2007-09-01 00:00:00