Fungus-specific translation elongation factor 3 gene present in Pneumocystis carinii.

Abstract:

:Historically, Pneumocystis carinii pneumonia has been the most frequent cause of morbidity and mortality in patients with AIDS. Antiprotozoan drugs are effective in the treatment and prophylaxis of P. carinii pneumonia, which lends credence to the widely held view that P. carinii is a protozoan. However, recent genetic evidence suggests that P. carinii should be classified as a fungus. Translation elongation factor 3 (EF-3) is an essential, soluble translation component which is unique to fungal protein synthesis and is not required for protein synthesis in other eukaryotes. We have identified and isolated a gene for EF-3 from P. carinii, adding more evidence for this organism's assignment as a fungus.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Ypma-Wong MF,Fonzi WA,Sypherd PS

doi

10.1128/IAI.60.10.4140-4145.1992

keywords:

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

4140-5

issue

10

eissn

0019-9567

issn

1098-5522

journal_volume

60

pub_type

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