Abstract:
OBJECTIVE:To describe the pathological features of three very similar and unusual primary central nervous system tumors that are not readily recognized as conventional ependymomas but which, by ultrastructural examination, have an ependymomatous character. METHODS:Three distinctive tumors were found in a review of our files for cases of ependymoma. In each case, hematoxylin and eosin-stained sections were reviewed, and immunostains for epithelial membrane antigen, cytokeratin, vimentin, and glial fibrillary acidic protein were performed on formalin-fixed, paraffin-embedded sections. Electron microscopy was performed in each case. RESULTS:The tumors had a diffuse myxoid background, often containing tightly clustered cells that mimicked multinucleated giant cells, but lacking perivascular pseudorosettes or central lumen rosettes. Glial fibrillary acidic protein and vimentin immunostains did not reveal perivascular processes. Epithelial membrane antigen immunostains showed a dot-like cytoplasmic immunoreactivity in some cell clusters in two of the three cases. Cytokeratin was negative in all three cases. However, ultrastructurally, the cells of each tumor had extensive surface microvilli; the giant cell-like clusters had cells with extensive close appositions, some junctions, and, in two cases, lumina with microvilli. Two of the patients were adults (both with temporal lobe tumors), and one patient was 13 years old and had a cervical spinal cord intramedullary tumor. Each tumor was sharply circumscribed from adjacent central nervous system tissue but was not encapsulated. One of the cases in an adult was mitotically highly active; this tumor recurred locally 4 years after initial gross total excision. CONCLUSION:These tumors are unusual variants of ependymoma. This pattern of ependymoma is sufficiently distinctive to be recognized in hematoxylin and eosin stains once the architecture of the epithelioid clusters is appreciated.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Kleinman GM,Zagzag D,Miller DCdoi
10.1227/01.neu.0000079628.55729.12keywords:
subject
Has Abstractpub_date
2003-09-01 00:00:00pages
743-7; discussion 747-8issue
3eissn
0148-396Xissn
1524-4040journal_volume
53pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract::This review article outlines basic concepts and pathophysiological aspects of the chemistry of oxygen free radicals in all forms of brain injury and brain edema. Recent experimental studies have demonstrated that oxygen free radicals may be important mediators of brain injury and brain edema, and pharmacological antag...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-199007000-00001
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:The most common postoperative complication of the transsphenoidal approach is cerebrospinal fluid (CSF) rhinorrhea. If the dura is widely opened beyond the sellar floor and massive intraoperative CSF leakage is encountered, then the conventional packing method, in which the sella turcica is filled with pieces...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000108780.72365.dc
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To search for correlations between specific anatomic, geometric, and morphological properties of the trigeminal nerve and the success of radiosurgical treatment and elimination of facial hypesthesia as a complication. METHODS:Forty-six patients with at least 6 months of follow-up after CyberKnife (Accuray, I...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000340795.87734.70
更新日期:2009-02-01 00:00:00
abstract::The authors present a patient with a large arteriovenous malformation in the temperoparietooccipital region of the dominant hemisphere that caused seizures, a homonymous hemianopia, and broad neuropsychological disturbances probably caused by a cerebral steal syndrome. There was no history of hemorrhage. Surgical rese...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198712000-00009
更新日期:1987-12-01 00:00:00
abstract::Two case reports of compression of the cervical spinal cord associated with silicone-coated Dacron dural grafts are presented. In both cases, the cervical spinal cord was distorted and compressed by an intense tissue reaction that encapsulated the synthetic graft. At least two factors are thought to play a role in pre...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198901000-00022
更新日期:1989-01-01 00:00:00
abstract::Cerebral arterial vasospasm continues to be a major secondary medical complication of aneurysmal subarachnoid hemorrhage. Despite hypervolemic hemodilution, arterial hypertension, and pharmacological therapy, morbidity and mortality due to vasospasm remain high. The authors discuss a patient with vasospasm who did not...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199505000-00024
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:Medical students applying for neurosurgery residency positions almost all aspire to become academic neurosurgeons. However, most graduates of neurosurgery residency programs ultimately follow careers in private practice. We hypothesized that there might be factors in a resident's application, interviews, or p...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000255445.51989.33
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:Pediatric epilepsy surgery candidates with unilateral congenital or early-acquired brain lesions may present with refractory seizures and generalized electroencephalographic features such as electrical status epilepticus in sleep (ESES). The purpose of our study was to review the clinical presentation, neuroi...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000336767.14252.76
更新日期:2009-02-01 00:00:00
abstract::With the advent of more sensitive diagnostic techniques, we are encountering an increasing number of young patients harboring cerebral astrocytoma. The great danger in such patients is that the astrocytoma cells will undergo dedifferentiation to a higher state of malignancy. An essential question is whether the use of...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198706000-00028
更新日期:1987-06-01 00:00:00
abstract::The authors describe a new suction device with prehensile properties that has proved itself particularly useful in the removal of certain types of tumor, especially extramedullary. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198710000-00031
更新日期:1987-10-01 00:00:00
abstract:OBJECTIVE:To analyze the risk factors of worst outcome associated with moderate head injury. METHODS:Data on patients with moderate head injury were collected prospectively in 11 Italian neurosurgical units over a period of 18 months. Patients older than 18 years with blunt head injury and at least one Glasgow Coma Sc...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1227/01.NEU.0000340796.18738.F7
更新日期:2009-04-01 00:00:00
abstract::Thirty-five consecutive adults with Chiari malformation and progressive symptoms underwent surgical treatment at a single institution over a 3-year period. All patients underwent magnetic resonance imaging scan before and after surgery. Images of the craniovertebral junction confirmed tonsillar herniation in all cases...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:Previous reports identified the presence of traumatic subarachnoid hemorrhage (tSAH) on admission computed tomographic (CT) scans as an independent prognostic factor in worsening outcomes. The mechanism underlying the link between tSAH and prognosis has not been clarified. The aim of this study was to investi...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200202000-00006
更新日期:2002-02-01 00:00:00
abstract::Neurosurgery in Uganda was virtually non-existent up until late 1960s. This changed when Dr. Jovan Kiryabwire spearheaded development of a neurosurgical unit at Mulago Hospital in Kampala. His work ethic and vision set the stage for rapid expansion of neurosurgical care in Uganda.At the beginning of the 2000s, Uganda ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyw159
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:The promising results of the Solitaire Flow Restoration (FR) With the Intention for Thrombectomy (SWIFT) trial recently led to Food and Drug Administration (FDA) approval of the Solitaire FR stent retriever device for recanalization of cerebral vessels in patients with acute ischemic stroke. OBJECTIVE:To re...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1227/01.neu.0000429859.96652.57
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:The prognosis of giant aneurysms remains poor despite recent advances in microneurosurgery. Thick-walled and partially calcified giant aneurysms with an atheromatic base are difficult to clip safely. Special techniques allowing reshaping of the base and ensuring the stability of clips are often needed. We pre...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000330400.68015.88
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:In Asian populations, moyamoya disease has a well-defined phenotype including a bimodal age of presentation with children typically presenting with ischemic phenomena and adults presenting with hemorrhage. Studies have provided evidence that moyamoya disease in the United States may exhibit a different pheno...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e318253ab8e
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Accidental vessel occlusion is one major risk of intracranial aneurysm surgery potentially causing cerebral ischemia. The intraoperative assessment of cerebral ischemia remains a technological challenge. OBJECTIVE:As a novel approach, cortical tissue integrity was monitored using simultaneous measurements o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e3182178bc9
更新日期:2011-08-01 00:00:00
abstract::Cell therapy has been widely recognized as a promising strategy to enhance recovery in stroke survivors. However, despite an abundance of encouraging preclinical data, successful clinical translation remains elusive. As the field continues to advance, it is important to reexamine prior clinical trials in the context o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyaa531
更新日期:2020-12-28 00:00:00
abstract::To elucidate the pathophysiology of mental disturbances associated with chronic subdural hematoma, we performed quantitative and three-dimensional measurements of cerebral blood flow (CBF) on xenon-enhanced computed tomographic scans in 12 patients who had chronic subdural hematomas and manifested mental disturbances....
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199203000-00010
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:The incidence of traumatic craniocervical artery dissection varies in published trauma series. OBJECTIVE:To determine the frequency of traumatic craniocervical artery injury in polytrauma patients by using standardized whole-body trauma computed tomography with adapted computed tomography angiography of the...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31821a8701
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:This work evaluates the potential of lipid-coated microbubbles (LCM) as a delivery vehicle for lipid-soluble antineoplastic agents. We have shown, in rats, the selective affinity of intravenously administered LCM for tumor cells. They are internalized by the tumor cells both in vitro and in vivo. The specific...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199706000-00028
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:Dural replacements are used in cranial surgery when primary closure of native dura is not possible. The goal is to recreate a watertight barrier to prevent cerebrospinal fluid leakage with few associated complications. We reviewed a single-institution experience with a variety of dural substitutes in posterio...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000334414.79963.59
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Stent-assisted coiling in the setting of subarachnoid hemorrhage remains controversial. Currently, there is a paucity of data regarding the utility of this procedure and the risks of hemorrhagic and ischemic complications. OBJECTIVE:To assess the utility of stent-assisted coil embolization and pretreatment ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e318246a4b1
更新日期:2012-06-01 00:00:00
abstract::We describe a very rare case of distal anterior choroidal artery aneurysm. A 34-year-old woman was admitted to our hospital because of headache and vomiting. Computed tomographic scans revealed a diffuse intraventricular hematoma and a thin subarachnoid hemorrhage. Cerebral angiography disclosed a saccular aneurysm in...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/00006123-199305000-00018
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Cerebrovascular autoregulation (CA) is an important hemodynamic mechanism that protects the brain against inappropriate fluctuations in cerebral blood flow in the face of changing cerebral perfusion pressure. Temporal CA failure is associated with worse outcomes in various acute neurological diseases. An int...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000001192
更新日期:2016-07-01 00:00:00
abstract::The computed tomographic (CT) scan has replaced angiography in the preoperative neurodiagnostic evaluation of the common pediatric posterior fossa tumors. This case report illustrates that rarely an atypical vascular anomaly may masquerade as a neoplasm and angiography must not be dismissed if the CT scan is any way a...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198006000-00011
更新日期:1980-06-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Herein we describe two cases of extracranial-intracranial vein graft bypasses for the treatment of giant intracranial aneurysms in prepubertal pediatric patients. One patient is, we think, the youngest patient reported in the literature to have been successfully treated in such a manner, with a...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200203000-00048
更新日期:2002-03-01 00:00:00
abstract::Recent advances in electronics and microprocessors have enabled the development of a compact portable cerebral blood flow (CBF) machine capable of being transported to the patient's bedside. We have used such a device, the Novo Cerebrograph 2a, during the past 7 months on a regular basis in the day to day management o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198410000-00008
更新日期:1984-10-01 00:00:00
abstract::Although multiple cerebral aneurysms ae well recognized, a new aneurysm has only rarely been documented after successful treatment for an aneurysm elsewhere. In our consecutive series of 986 patients with intracranial saccular arterial aneurysm collected from 1975 to 1990, nine patients who had previously unverified (...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199304000-00004
更新日期:1993-04-01 00:00:00