Abstract:
:This review article outlines basic concepts and pathophysiological aspects of the chemistry of oxygen free radicals in all forms of brain injury and brain edema. Recent experimental studies have demonstrated that oxygen free radicals may be important mediators of brain injury and brain edema, and pharmacological antagonism of oxygen free radicals shows beneficial therapeutic results. A number of fundamental questions need to resolved, and advanced techniques for detecting oxygen free radicals will be needed. No clinical data are available, but oxygen free radical scavengers may possibly become a critical therapeutic modality for brain injury and brain edema.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Ikeda Y,Long DMdoi
10.1097/00006123-199007000-00001subject
Has Abstractpub_date
1990-07-01 00:00:00pages
1-11issue
1eissn
0148-396Xissn
1524-4040journal_volume
27pub_type
杂志文章,评审相关文献
NEUROSURGERY文献大全abstract:OBJECTIVE:Most of the endoscopes used for endonasal transsphenoidal surgery use 4-mm diameter lenses. The applicability of a newly developed neuroendoscope with a lens diameter of only 2 mm was tested in endonasal transsphenoidal pituitary surgery. METHODS:The newly developed rigid-rod neuroendoscope with a 2-mm lens ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000255381.64969.C8
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:Cerebral syphilitic gummata are rare manifestations of tertiary, meningovascular syphilis. No extensive characterization of these lesions has been published recently, and only a few small reviews containing imaging findings have been published to date. To better characterize cerebral gummata, we present a cas...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.NEU.0000337079.12137.89
更新日期:2009-03-01 00:00:00
abstract::Fifty-one surgical decompressions without nerve transposition for ulnar neuropathy were performed in 46 patients. All of the patients were men with an average age of 59 years at the time of surgery. The follow-up range was between 5 and 32 months (average, 17.8 months). The disease involved the nondominant arm in 24 p...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199011000-00007
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVE:To analyze the risk factors of worst outcome associated with moderate head injury. METHODS:Data on patients with moderate head injury were collected prospectively in 11 Italian neurosurgical units over a period of 18 months. Patients older than 18 years with blunt head injury and at least one Glasgow Coma Sc...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1227/01.NEU.0000340796.18738.F7
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Anterior cingulotomy (AC) can be an effective therapy for patients with severe obsessive-compulsive disorder who are refractory to traditional medical therapy. For patients who do not respond to AC, the benefit of additional lesion procedures vs continued medical management remains unknown. OBJECTIVE:To det...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31827b9c7c
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Animal studies suggest that ischemic preconditioning prolongs coagulation times. OBJECTIVE:Because coagulation changes could hinder the translation of preconditioning into clinical settings where hemorrhage may be an issue, such as ischemic or hemorrhagic stroke, we evaluated the effects of remote ischemic ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000098
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Rugby is characterized by high-speed collisions among the players that predispose them to injuries, particularly to the head, neck, and spine. OBJECTIVE:To evaluate the effectiveness of current neurological injury prevention strategies in rugby union. METHODS:Systematic review in May 2010. We assessed the ...
journal_title:Neurosurgery
pub_type: 杂志文章,meta分析,评审
doi:10.1227/NEU.0b013e3181f209f1
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration. OBJECTIVE:To determine if fluorescence represents a prognostic marker in LGG. METHODS:Seventy-four consecutive patients with LGG (World Health Organiza...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyy365
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:Herpes virus encephalitis is a rare, life-threatening complication of therapy in patients with brain tumors. A surgical therapeutic approach may be needed because the infection can be resistant to acyclovir in immunocompromised patients, and complications and long-term sequelae are frequent. CLINICAL PRESENT...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000325885.00033.c3
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Nimodipine is commonly used to improve neurological outcomes after subarachnoid hemorrhage. Although nimodipine reportedly has high specificity for the cerebral vasculature, adverse systemic effects such as hypotension have been described. This case report describes a patient with traumatic sub...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200011000-00048
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Over the last several decades, significant advances have occurred in the assessment and management of spinal deformity. OBJECTIVE:The primary focus of this narrative review is on recent advances in adult thoracic, thoracolumbar, and lumbar deformities, with additional discussions of advances in cervical def...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1093/neuros/nyw048
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:Delayed cerebral ischemia resulting from vasospasm is a major cause of morbidity and death in patients with aneurysmal subarachnoid hemorrhage. Milrinone, because it inhibits Type IV cyclic adenosine monophosphate-specific phosphodiesterase enzyme in both cardiac and vascular smooth muscle, is a powerful inot...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199702000-00025
更新日期:1997-02-01 00:00:00
abstract::Bullfighting is a highly popular activity during festivities in Spain and Latin America. A scientific society for bullfight injuries, Congreso Internacional de Cirugía Taurina, was founded on November 24, 1974, in recognition of the distinctive pattern of injury that results from bull goring, and a subspecialty of gen...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/NEU.0b013e3182191fb1
更新日期:2011-08-01 00:00:00
abstract::A case of choroid plexus papilloma of the cerebellopontine angle that was revealed by a subarachnoid hemorrhage in a 5-year-old boy is presented. Subarachnoid hemorrhage and choroid plexus papilloma in children are discussed. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198407000-00023
更新日期:1984-07-01 00:00:00
abstract::THE VIETNAM WAR touched a generation of Americans with its human tragedy, sacrifice, and strife. In terms of casualties, it was the fourth most costly war in American history. However, despite a monumental military effort and modern technology, the war was lost as support from the American public and its elected offic...
journal_title:Neurosurgery
pub_type: 历史文章,杂志文章
doi:10.1227/01.neu.0000053179.51319.d0
更新日期:2003-04-01 00:00:00
abstract::The effects of mannitol on the cerebral microcirculation were studied using isolated perfused intracerebral (parenchymal) arterioles in rats. After vessels developed spontaneous tone, increasing concentrations of mannitol were applied extraluminally. Mannitol induced vasodilation in a dose-dependent manner. In an init...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198911000-00009
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:In selected patients, extracranial-intracranial bypass remains an important treatment for the prevention of stroke. Traditionally, superficial temporal artery-middle cerebral artery (STA-MCA) bypass uses 1 STA branch. We have adopted a "double-barrel" technique in which both branches are joined with MCA reci...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e318285b587
更新日期:2013-09-01 00:00:00
abstract::Prostaglandin E2, thromboxane B2, and 6-oxo-prostaglandin F1 alpha were assayed in blood and cerebrospinal fluid samples from patients after subarachnoid hemorrhage (SAH) and from a control population. The levels found in samples obtained from patients after SAH were compared with those found in controls and were also...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199201000-00004
更新日期:1992-01-01 00:00:00
abstract::The time course, anatomic distribution, and extent of changes in cerebral lactate, N-acetyl-L-aspartate (NAA), and other metabolite levels determined by three-dimensional in vivo 1H magnetic resonance spectroscopy and single-voxel spectral analysis after middle cerebral artery occlusion in rats. Increased lactate was ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199601000-00030
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:To study the application of navigated stereoscopic display of preoperative three-dimensional (3-D) magnetic resonance angiography and intraoperative 3-D ultrasound angiography in a clinical setting. METHODS:Preoperative magnetic resonance angiography and intraoperative ultrasound angiography are presented as...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000279232.43202.82
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:The recent successful development of chronic stimulation of the motor cortex as a treatment for neuropathic and central pain does not exclude the possibility of eventual side effects, such as epileptic seizure or a lowering of the epileptic threshold. This study evaluates the behavioral and electroencephalogr...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199908000-00030
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Spinal cord cavernous malformations (CMs) are associated with 2 types of angiographically occult "cryptic venous anomalies," which differ in location with respect to the spinal cord. The anatomic distinction between superficial and intramedullary is important in that the latter heighten the risks of CM resec...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31825d8f9a
更新日期:2012-09-01 00:00:00
abstract::Medical and surgical graduate medical education has historically used a halstedian approach of "see one, do one, teach one." Increased public demand for safety, quality, and accountability in the setting of regulated resident work hours and limited resources is driving the development of innovative educational tools. ...
journal_title:Neurosurgery
pub_type: 历史文章,杂志文章,评审
doi:10.1227/NEU.0000000000000093
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Intraoperative neurophysiological monitoring, including upper- and lower-extremity somatosensory evoked potentials (SSEPs), has been used to identify and prevent injury to neurovascular structures during conventional skull base surgery. The expanded endonasal approach (EEA) is a novel minimally invasive appr...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31821606e4
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:Intraoperative rupture (IOR) of an aneurysm is a known risk in the surgical management of intracranial aneurysms. The purpose of this study was to determine the incidence of IOR in a modern surgical series and to assess which factors bear upon it. METHODS:This study retrospectively examined 1269 patients wit...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.neu.0000154697.75300.c2
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Intracranial giant optic nerve gliomas, usually presumed as optic chiasmatic gliomas, are much less common. The architectural tumor form of optic nerve glioma without neurofibromatosis type 1 is usually the expansile-intraneural pattern. The exophytic optic nerve gliomas without neurofibromatos...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000204308.59999.60
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:The biggest downside of cerebral aneurysm coiling is the high rates of recurrence and retreatments. With the increasing number of aneurysm recurrences after failed coiling procedures, the best retreatment strategy remains unknown. OBJECTIVE:To assess the efficacy and safety of the Pipeline Embolization Devi...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000901
更新日期:2015-11-01 00:00:00
abstract::Oligodendrogliomas occur primarily in the cerebral hemispheres of adults. A rare case of an oligodendroglioma in the cerebellum of a child is presented. The tendency for oligodendroglioma to metastasize through the cerebrospinal fluid (CSF) is reviewed and emphasized. A recommendation for CSF cytology and possible spi...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198005000-00010
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether embryonic central nervous system transplants assisted cut dorsal root axons of adult rats to regenerate into the spinal cord. METHODS:Rats received transplants of embryonic spinal cord, hippocampus, or neocortex into dorsal quadrant cavities aspirated in the lum...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199910000-00024
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Epithelial cysts of the central nervous system are unusual entities, with the majority reported to occur in the spinal canal. More unusual is the intracranial presentation, which shows a predilection for midline localization in the posterior fossa, brainstem, and suprasellar regions. This repor...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:
更新日期:2002-08-01 00:00:00