The molecular basis of brain injury and brain edema: the role of oxygen free radicals.

Abstract:

:This review article outlines basic concepts and pathophysiological aspects of the chemistry of oxygen free radicals in all forms of brain injury and brain edema. Recent experimental studies have demonstrated that oxygen free radicals may be important mediators of brain injury and brain edema, and pharmacological antagonism of oxygen free radicals shows beneficial therapeutic results. A number of fundamental questions need to resolved, and advanced techniques for detecting oxygen free radicals will be needed. No clinical data are available, but oxygen free radical scavengers may possibly become a critical therapeutic modality for brain injury and brain edema.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Ikeda Y,Long DM

doi

10.1097/00006123-199007000-00001

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

1-11

issue

1

eissn

0148-396X

issn

1524-4040

journal_volume

27

pub_type

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