Abstract:
:The effects of mannitol on the cerebral microcirculation were studied using isolated perfused intracerebral (parenchymal) arterioles in rats. After vessels developed spontaneous tone, increasing concentrations of mannitol were applied extraluminally. Mannitol induced vasodilation in a dose-dependent manner. In an initial series of vessels, a 2% mannitol solution produced a maximal increase of vessel diameter of 35.8 +/- 2.2% (mean +/- SEM; n = 5). The degree of vasodilation was comparable to that produced by a sucrose solution of nearly equal osmolarity, suggesting that mannitol produced nonspecific vasodilation by increasing osmolarity. Organ bath solution pH was varied to 6.8 and 7.6 from the control pH of 7.3 in order to examine the effects of mannitol on vessels with different degrees of vessel tone. The mannitol dose-response curves in these vessels were parallel to each other, indicating that vasodilating effects of mannitol are essentially constant irrespective of the initial tone state of the vessel. In a second series of experiments, the effects of intraluminally applied mannitol on intracerebral arterioles were examined and compared to extraluminal application. Intraluminal application of 2% mannitol solutions produced a 42.6 +/- 2.0% (n = 5) increase in vessel diameter, which was not significantly different from that produced by extraluminal application (42.5 +/- 2.9%; n = 5; p = 0.89). Our results indicate that the direct action of mannitol on vascular smooth muscle in intracerebral arterioles is vasodilation.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Takayasu N,Dacey RG Jrdoi
10.1097/00006123-198911000-00009subject
Has Abstractpub_date
1989-11-01 00:00:00pages
747-51; discussion 751-2issue
5eissn
0148-396Xissn
1524-4040journal_volume
25pub_type
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