Abstract:
:Cell therapy has been widely recognized as a promising strategy to enhance recovery in stroke survivors. However, despite an abundance of encouraging preclinical data, successful clinical translation remains elusive. As the field continues to advance, it is important to reexamine prior clinical trials in the context of their intended mechanisms, as this can inform future preclinical and translational efforts. In the present work, we review the major clinical trials of cell therapy for stroke and highlight a mechanistic shift between the earliest studies, which aimed to replace dead and damaged neurons, and later ones that focused on exploiting the various neuromodulatory effects afforded by stem cells. We discuss why both mechanisms are worth pursuing and emphasize the means through which cell replacement can still be achieved.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Gu BJ,Kung DK,Chen HIdoi
10.1093/neuros/nyaa531subject
Has Abstractpub_date
2020-12-28 00:00:00eissn
0148-396Xissn
1524-4040pii
6054569pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract:BACKGROUND:The Pipeline Embolization Device is a widely utilized flow diverter in the treatment of intracranial aneurysms. OBJECTIVE:To assess the incidence, clinical significance, predictors, and outcomes of in-Pipeline stenosis (IPS). METHODS:Angiographic studies in 139 patients treated between 2011 and 2013 were i...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000908
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:En bloc resection of primary sacral tumors has a demonstrated survival benefit. Total and high sacral amputations are traditionally performed by using a staged anterior and subsequent posterior approach. However, we have found that en bloc resection and biomechanical reconstruction of the spinal column is po...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1227/NEU.0b013e31825d01d4
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:A number of publications suggest that there are seasonal influences on the incidence of subarachnoid hemorrhage (SAH). Most series agree on a peak incidence during springtime. Meteorological influences have been assumed to be obvious explanations for seasonal variations. Furthermore, the perceived clustering ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000325864.91584.c7
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To define the factors of importance for the obliteration of cerebral arteriovenous malformations (AVMs), thus making a prediction of the probability for obliteration possible. METHODS:In 945 AVMs of a series of 1319 patients treated with the gamma knife during 1970 to 1990, the relationship between patient, ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199703000-00001
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:Patients undergoing surgery for degenerative cervical spine disease may require future surgery for disease progression. We investigated factors related to the rate of additional cervical spine surgery, the associated length of stay, and hospital charges. METHODS:The was a longitudinal retrospective cohort st...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000360347.10596.BD
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:The corpus callosum is the major commissural pathway connecting the hemispheres of the human brain. It is particularly important, because various tumors and vascular lesions can be located in and around the corpus callosum, and it is a route through which pass several surgical approaches. Performing accurate ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199612000-00001
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:We report the safety and feasibility of using convection-enhanced delivery to administer Cotara (Peregrine Pharmaceuticals, Inc., Tustin, CA), a novel radioimmunotherapeutic agent, to patients with malignant glioma. METHODS:Between April 1998 and November 2002, 51 patients with histologically confirmed malig...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1227/01.neu.0000159649.71890.30
更新日期:2005-06-01 00:00:00
abstract::Intracranial lipomas are uncommon and rarely symptomatic lesions accounting for 0.06 to 0.46% of intracranial lesions. The management of symptomatic dorsal brain stem lipomas was once limited to cerebrospinal fluid diversion, but with recent advances in microsurgery, they now may be directly treated. We report three p...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199605000-00035
更新日期:1996-05-01 00:00:00
abstract::PURPOSE: To describe the design and performance of a novel frameless system for radiosurgery. This technology, called image-guided radiosurgery (IGR), eliminates the need for stereotactic frame fixation by relating the identified lesion to radiographic landmarks. CONCEPT: IGR uses a lightweight x-band linear accelerat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:The beaten copper appearance of the cranium, as well as other cranial radiographic and computed tomographic findings in children with craniosynostosis, is often interpreted by clinicians as evidence of elevated intracranial pressure (ICP). However, a correlation between radiological findings and ICP measureme...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199610000-00007
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:To study interhemispheric differences of somatosensory evoked field (SEF) characteristics and the spatial distribution of equivalent current dipole sources in patients with unilateral hemispheric lesions around the central sulcus region. METHODS:In 17 patients with perirolandic lesions, averaged somatosensor...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000306099.45764.5c
更新日期:2007-12-01 00:00:00
abstract::To improve the localization of stereotactic targets, somatosensory evoked potentials (SEPs) were recorded from the thalamus and subthalamic area using a specially designed semimicroelectrode in 61 patients and a conventional "macroelectrode" in 17 patients. By means of the semimicroelectrode, median nerve stimulation ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199102000-00008
更新日期:1991-02-01 00:00:00
abstract::Granulocytic sarcoma (GS) usually occurs during the course of, or as a presenting sign of myelogenous leukemia. Rarely it is found before peripheral blood or bone marrow evidence of leukemia is present. We describe a man who presented with low back pain and lower extremity weakness. He had spinal cord compression due ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198901000-00024
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:Preliminary clinical experience with a novel, compact, intraoperative magnetic resonance imaging (MRI)-guided system that can be used in an ordinary operating room is presented. DESCRIPTION OF INSTRUMENTATION:The system features an MRI scanner integrated with an optical and MRI tracking system. Scanning and ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200104000-00021
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Observational methods can be used in conjunction with the comparative effectiveness research (CER) paradigm to inform decisions between alternative patient management strategies in real-world clinical settings. OBJECTIVE:To present a brief review of current observational research regarding 3 strategies for ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31820cd45a
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:The benefits of radiation therapy are generally denied to infants with malignant brain tumors because of the risk of devastating cognitive decline. Efforts to limit this morbidity with radiosurgical techniques have not been feasible for infants because of the dual requirements of rigid head fixation and high ...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1227/01.neu.0000137332.03970.57
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Flow-diverting stents offer a promising treatment option for complex aneurysms. OBJECTIVE:To evaluate the safety and efficacy of the Pipeline embolization device (PED) in the treatment of fusiform and dissecting aneurysms. METHODS:Sixty-five consecutive patients with 69 fusiform and dissecting aneurysms un...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0000000000000431
更新日期:2014-10-01 00:00:00
abstract::This study examines the pathophysiology of stroke secondary to focal cerebral ischemia. The interaction of arachidonic acid metabolites and polyamines, a class of ubiquitous ornithine-derived molecules with important membrane effects on edema, Ca++-dependent endocytosis, platelet function, and prostaglandin (PG) forma...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198510000-00017
更新日期:1985-10-01 00:00:00
abstract::A rare and serious complication of ventriculoperitoneal shunt is reported. A huge intraventricular hematoma was confirmed by computed tomography scanning and autopsy. This is the first report of such a complication in a newborn with hydrocephalus. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198203000-00016
更新日期:1982-03-01 00:00:00
abstract:OBJECTIVE:Interleukin-12 (IL-12) may be useful for immunotherapy against gliomas because it can reverse the glioma-induced suppression of T-cell proliferation and interferon-gamma production. We postulated that peripheral infusion of IL-12 along with irradiated tumor cells can lead to immunological rejection of 9L glio...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199804000-00097
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:The advantages of a posterior "conventional" suboccipital approach with a midline incision over lateral, anterolateral, and anterior approaches to anteriorly placed foramen magnum meningiomas are discussed. METHODS:From 1991 to March 2000, 17 patients with foramen magnum meningiomas arising from the anterior...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-200107000-00016
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:Resection of intracranial tumors in the posterior hippocampus and the parahippocampal gyrus can be associated with significant morbidity because of the parenchymal resection and the cortical retraction often required in gaining access to this infrequently explored region. With the use of image guidance, the o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200205000-00010
更新日期:2002-05-01 00:00:00
abstract::The thorascopic approach for the microsurgical removal of herniated thoracic discs is described, and perioperative management is also discussed. The microsurgical techniques used for decompression of the spinal canal in the thoracic spine are presented in detail. The diagnostic imaging, surgical positioning, approach,...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200201000-00018
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The optimal management of unruptured brain arteriovenous malformations (AVMs) is controversial after the ARUBA trial. OBJECTIVE:To confirm or repudiate the ARUBA conclusion that "medical management only is superior to medical management with interventional therapy for unruptured brain arteriovenous malforma...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyy391
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Although previous evidence suggests that the cognitive effects of concussions are cumulative, the effect of time interval between repeat concussions is largely unknown. OBJECTIVE:To determine the effect of time interval between repeat concussions on the cognitive function of mice. METHODS:We used a weight-...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e318265a439
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Brain metastases represent the most common intracranial tumors and are associated with very poor prognosis. OBJECTIVE:To investigate the feasibility, survival, and cerebral disease control of patients with singular brain metastases treated with stereotactic 125iodine brachytherapy (SBT), to identify prognos...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31820b526a
更新日期:2011-05-01 00:00:00
abstract::In the May 2009 issue of The Lancet Neurology, the 5-year follow-up results of the International Subarachnoid Aneurysm Trial (ISAT) were published. The authors concluded that, although the significant difference between coiling and neurosurgical clipping of ruptured intracranial aneurysms in terms of death and severe ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000368152.67151.73
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Calcification of the ligamentum flavum is a rare disease that occurs almost exclusively in elderly Japanese people. We report the case of a young Caucasian woman who presented with a C5-C6 disc herniation associated with a cervical calcified ligamentum flavum. CLINICAL PRESENTATION:The patient...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200103000-00047
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To study the biomechanical behavior of lumbar interbody instrumentation techniques using titanium cages as either transforaminal lumbar interbody fusion (TLIF) or anterior lumbar interbody fusion (ALIF), with and without posterior pedicle fixation. METHODS:Six fresh-frozen lumbar spines (L1-L5) were loaded w...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000245609.01732.E4
更新日期:2006-12-01 00:00:00
abstract::Immortalized in surgical history for the introduction of "antiseptic wax," Sir Victor Horsley played a pivotal role in shaping the face of standard neurosurgical practice. His contributions include the first laminectomy for spinal neoplasm, the first carotid ligation for cerebral aneurysm, the curved skin flap, the tr...
journal_title:Neurosurgery
pub_type: 传,历史文章,杂志文章
doi:10.1097/00006123-200203000-00032
更新日期:2002-03-01 00:00:00