Cell Therapy for Stroke: A Mechanistic Analysis.

Abstract:

:Cell therapy has been widely recognized as a promising strategy to enhance recovery in stroke survivors. However, despite an abundance of encouraging preclinical data, successful clinical translation remains elusive. As the field continues to advance, it is important to reexamine prior clinical trials in the context of their intended mechanisms, as this can inform future preclinical and translational efforts. In the present work, we review the major clinical trials of cell therapy for stroke and highlight a mechanistic shift between the earliest studies, which aimed to replace dead and damaged neurons, and later ones that focused on exploiting the various neuromodulatory effects afforded by stem cells. We discuss why both mechanisms are worth pursuing and emphasize the means through which cell replacement can still be achieved.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Gu BJ,Kung DK,Chen HI

doi

10.1093/neuros/nyaa531

subject

Has Abstract

pub_date

2020-12-28 00:00:00

eissn

0148-396X

issn

1524-4040

pii

6054569

pub_type

杂志文章
  • In-Pipeline Stenosis: Incidence, Predictors, and Clinical Outcomes.

    abstract:BACKGROUND:The Pipeline Embolization Device is a widely utilized flow diverter in the treatment of intracranial aneurysms. OBJECTIVE:To assess the incidence, clinical significance, predictors, and outcomes of in-Pipeline stenosis (IPS). METHODS:Angiographic studies in 139 patients treated between 2011 and 2013 were i...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000908

    authors: Chalouhi N,Polifka A,Daou B,Kung D,Barros G,Tjoumakaris S,Gonzalez LF,Starke RM,Hasan D,Judy B,Rosenwasser RH,Jabbour P

    更新日期:2015-12-01 00:00:00

  • Posterior-only approach for en bloc sacrectomy: clinical outcomes in 36 consecutive patients.

    abstract:BACKGROUND:En bloc resection of primary sacral tumors has a demonstrated survival benefit. Total and high sacral amputations are traditionally performed by using a staged anterior and subsequent posterior approach. However, we have found that en bloc resection and biomechanical reconstruction of the spinal column is po...

    journal_title:Neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.1227/NEU.0b013e31825d01d4

    authors: Clarke MJ,Dasenbrock H,Bydon A,Sciubba DM,McGirt MJ,Hsieh PC,Yassari R,Gokaslan ZL,Wolinsky JP

    更新日期:2012-08-01 00:00:00

  • Dependence of subarachnoid hemorrhage on climate conditions: a systematic meteorological analysis from the dusseldorf metropolitan area.

    abstract:OBJECTIVE:A number of publications suggest that there are seasonal influences on the incidence of subarachnoid hemorrhage (SAH). Most series agree on a peak incidence during springtime. Meteorological influences have been assumed to be obvious explanations for seasonal variations. Furthermore, the perceived clustering ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000325864.91584.c7

    authors: Beseoglu K,Hänggi D,Stummer W,Steiger HJ

    更新日期:2008-05-01 00:00:00

  • Prediction of obliteration after gamma knife surgery for cerebral arteriovenous malformations.

    abstract:OBJECTIVE:To define the factors of importance for the obliteration of cerebral arteriovenous malformations (AVMs), thus making a prediction of the probability for obliteration possible. METHODS:In 945 AVMs of a series of 1319 patients treated with the gamma knife during 1970 to 1990, the relationship between patient, ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199703000-00001

    authors: Karlsson B,Lindquist C,Steiner L

    更新日期:1997-03-01 00:00:00

  • Cervical spine reoperation rates and hospital resource utilization after initial surgery for degenerative cervical spine disease in 12,338 patients in Washington State.

    abstract:OBJECTIVE:Patients undergoing surgery for degenerative cervical spine disease may require future surgery for disease progression. We investigated factors related to the rate of additional cervical spine surgery, the associated length of stay, and hospital charges. METHODS:The was a longitudinal retrospective cohort st...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000360347.10596.BD

    authors: King JT Jr,Abbed KM,Gould GC,Benzel EC,Ghogawala Z

    更新日期:2009-12-01 00:00:00

  • The arteries of the corpus callosum: a microsurgical anatomic study.

    abstract:OBJECTIVE:The corpus callosum is the major commissural pathway connecting the hemispheres of the human brain. It is particularly important, because various tumors and vascular lesions can be located in and around the corpus callosum, and it is a route through which pass several surgical approaches. Performing accurate ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199612000-00001

    authors: Türe U,Yaşargil MG,Krisht AF

    更新日期:1996-12-01 00:00:00

  • Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: initial experience in 51 patients.

    abstract:OBJECTIVE:We report the safety and feasibility of using convection-enhanced delivery to administer Cotara (Peregrine Pharmaceuticals, Inc., Tustin, CA), a novel radioimmunotherapeutic agent, to patients with malignant glioma. METHODS:Between April 1998 and November 2002, 51 patients with histologically confirmed malig...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1227/01.neu.0000159649.71890.30

    authors: Patel SJ,Shapiro WR,Laske DW,Jensen RL,Asher AL,Wessels BW,Carpenter SP,Shan JS

    更新日期:2005-06-01 00:00:00

  • Dorsal brain stem lipomas: case report.

    abstract::Intracranial lipomas are uncommon and rarely symptomatic lesions accounting for 0.06 to 0.46% of intracranial lesions. The management of symptomatic dorsal brain stem lipomas was once limited to cerebrospinal fluid diversion, but with recent advances in microsurgery, they now may be directly treated. We report three p...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199605000-00035

    authors: Baeesa SS,Higgins MJ,Ventureyra EC

    更新日期:1996-05-01 00:00:00

  • Image-guided robotic radiosurgery

    abstract::PURPOSE: To describe the design and performance of a novel frameless system for radiosurgery. This technology, called image-guided radiosurgery (IGR), eliminates the need for stereotactic frame fixation by relating the identified lesion to radiographic landmarks. CONCEPT: IGR uses a lightweight x-band linear accelerat...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Adler JR Jr,Murphy MJ,Chang SD,Hancock SL

    更新日期:1999-06-01 00:00:00

  • The beaten copper cranium: a correlation between intracranial pressure, cranial radiographs, and computed tomographic scans in children with craniosynostosis.

    abstract:OBJECTIVE:The beaten copper appearance of the cranium, as well as other cranial radiographic and computed tomographic findings in children with craniosynostosis, is often interpreted by clinicians as evidence of elevated intracranial pressure (ICP). However, a correlation between radiological findings and ICP measureme...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199610000-00007

    authors: Tuite GF,Evanson J,Chong WK,Thompson DN,Harkness WF,Jones BM,Hayward RD

    更新日期:1996-10-01 00:00:00

  • Magnetoencephalographic study of posterior tibial nerve stimulation in patients with intracranial lesions around the central sulcus.

    abstract:OBJECTIVE:To study interhemispheric differences of somatosensory evoked field (SEF) characteristics and the spatial distribution of equivalent current dipole sources in patients with unilateral hemispheric lesions around the central sulcus region. METHODS:In 17 patients with perirolandic lesions, averaged somatosensor...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000306099.45764.5c

    authors: Willemse RB,de Munck JC,van't Ent D,Ris P,Baayen JC,Stam CJ,Vandertop WP

    更新日期:2007-12-01 00:00:00

  • Localization of stereotactic targets by microrecordings of thalamic somatosensory evoked potentials.

    abstract::To improve the localization of stereotactic targets, somatosensory evoked potentials (SEPs) were recorded from the thalamus and subthalamic area using a specially designed semimicroelectrode in 61 patients and a conventional "macroelectrode" in 17 patients. By means of the semimicroelectrode, median nerve stimulation ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199102000-00008

    authors: Shima F,Morioka T,Tobimatsu S,Kavaklis O,Kato M,Fukui M

    更新日期:1991-02-01 00:00:00

  • Granulocytic sarcoma presenting as an epidural mass with cord compression.

    abstract::Granulocytic sarcoma (GS) usually occurs during the course of, or as a presenting sign of myelogenous leukemia. Rarely it is found before peripheral blood or bone marrow evidence of leukemia is present. We describe a man who presented with low back pain and lower extremity weakness. He had spinal cord compression due ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198901000-00024

    authors: Ripp DJ,Davis JW,Rengachary SS,Lotuaco LG,Watanabe IS

    更新日期:1989-01-01 00:00:00

  • Novel, compact, intraoperative magnetic resonance imaging-guided system for conventional neurosurgical operating rooms.

    abstract:OBJECTIVE:Preliminary clinical experience with a novel, compact, intraoperative magnetic resonance imaging (MRI)-guided system that can be used in an ordinary operating room is presented. DESCRIPTION OF INSTRUMENTATION:The system features an MRI scanner integrated with an optical and MRI tracking system. Scanning and ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200104000-00021

    authors: Hadani M,Spiegelman R,Feldman Z,Berkenstadt H,Ram Z

    更新日期:2001-04-01 00:00:00

  • A comparative effectiveness analysis of alternative strategies to assess hypothalamic-pituitary-adrenal axis function after microsurgical resection of pituitary tumors.

    abstract:BACKGROUND:Observational methods can be used in conjunction with the comparative effectiveness research (CER) paradigm to inform decisions between alternative patient management strategies in real-world clinical settings. OBJECTIVE:To present a brief review of current observational research regarding 3 strategies for ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e31820cd45a

    authors: Marko NF,Weil RJ

    更新日期:2011-06-01 00:00:00

  • Feasibility of radiosurgery for malignant brain tumors in infants by use of image-guided robotic radiosurgery: preliminary report.

    abstract:OBJECTIVE:The benefits of radiation therapy are generally denied to infants with malignant brain tumors because of the risk of devastating cognitive decline. Efforts to limit this morbidity with radiosurgical techniques have not been feasible for infants because of the dual requirements of rigid head fixation and high ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1227/01.neu.0000137332.03970.57

    authors: Giller CA,Berger BD,Gilio JP,Delp JL,Gall KP,Weprin B,Bowers D

    更新日期:2004-10-01 00:00:00

  • Pipeline embolization device for the treatment of intra- and extracranial fusiform and dissecting aneurysms: initial experience and long-term follow-up.

    abstract:BACKGROUND:Flow-diverting stents offer a promising treatment option for complex aneurysms. OBJECTIVE:To evaluate the safety and efficacy of the Pipeline embolization device (PED) in the treatment of fusiform and dissecting aneurysms. METHODS:Sixty-five consecutive patients with 69 fusiform and dissecting aneurysms un...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000431

    authors: Fischer S,Perez MA,Kurre W,Albes G,Bäzner H,Henkes H

    更新日期:2014-10-01 00:00:00

  • Polyamine and prostaglandin markers in focal cerebral ischemia.

    abstract::This study examines the pathophysiology of stroke secondary to focal cerebral ischemia. The interaction of arachidonic acid metabolites and polyamines, a class of ubiquitous ornithine-derived molecules with important membrane effects on edema, Ca++-dependent endocytosis, platelet function, and prostaglandin (PG) forma...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198510000-00017

    authors: Dempsey RJ,Roy MW,Meyer K,Tai HH,Olson JW

    更新日期:1985-10-01 00:00:00

  • Intraventricular hematoma secondary to a ventriculoperitoneal shunt.

    abstract::A rare and serious complication of ventriculoperitoneal shunt is reported. A huge intraventricular hematoma was confirmed by computed tomography scanning and autopsy. This is the first report of such a complication in a newborn with hydrocephalus. ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198203000-00016

    authors: Kuwamura K,Kokunai T

    更新日期:1982-03-01 00:00:00

  • Interleukin-12-based immunotherapy against rat 9L glioma.

    abstract:OBJECTIVE:Interleukin-12 (IL-12) may be useful for immunotherapy against gliomas because it can reverse the glioma-induced suppression of T-cell proliferation and interferon-gamma production. We postulated that peripheral infusion of IL-12 along with irradiated tumor cells can lead to immunological rejection of 9L glio...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199804000-00097

    authors: Jean WC,Spellman SR,Wallenfriedman MA,Hall WA,Low WC

    更新日期:1998-04-01 00:00:00

  • Surgery on anterior foramen magnum meningiomas using a conventional posterior suboccipital approach: a report on an experience with 17 cases.

    abstract:OBJECTIVE:The advantages of a posterior "conventional" suboccipital approach with a midline incision over lateral, anterolateral, and anterior approaches to anteriorly placed foramen magnum meningiomas are discussed. METHODS:From 1991 to March 2000, 17 patients with foramen magnum meningiomas arising from the anterior...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006123-200107000-00016

    authors: Goel A,Desai K,Muzumdar D

    更新日期:2001-07-01 00:00:00

  • Volumetric stereotaxy and the supratentorial occipitosubtemporal approach in the resection of posterior hippocampus and parahippocampal gyrus lesions.

    abstract:OBJECTIVE:Resection of intracranial tumors in the posterior hippocampus and the parahippocampal gyrus can be associated with significant morbidity because of the parenchymal resection and the cortical retraction often required in gaining access to this infrequently explored region. With the use of image guidance, the o...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200205000-00010

    authors: Russell SM,Kelly PJ

    更新日期:2002-05-01 00:00:00

  • Thoracoscopic microdiscectomy.

    abstract::The thorascopic approach for the microsurgical removal of herniated thoracic discs is described, and perioperative management is also discussed. The microsurgical techniques used for decompression of the spinal canal in the thoracic spine are presented in detail. The diagnostic imaging, surgical positioning, approach,...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200201000-00018

    authors: Oskouian RJ Jr,Johnson JP,Regan JJ

    更新日期:2002-01-01 00:00:00

  • The NASSAU (New ASSessment of cerebral Arteriovenous Malformations yet Unruptured) Analysis: Are the Results From The ARUBA Trial Also Applicable to Unruptured Arteriovenous Malformations Deemed Suitable for Gamma Knife Surgery?

    abstract:BACKGROUND:The optimal management of unruptured brain arteriovenous malformations (AVMs) is controversial after the ARUBA trial. OBJECTIVE:To confirm or repudiate the ARUBA conclusion that "medical management only is superior to medical management with interventional therapy for unruptured brain arteriovenous malforma...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyy391

    authors: Karlsson B,Jokura H,Yang HC,Yamamoto M,Martinez R,Kawagishi J,Guo WY,Beute G,Pan DHC,Aiyama H,Chung WY,Söderman M,Yeo TT

    更新日期:2019-07-01 00:00:00

  • Increasing recovery time between injuries improves cognitive outcome after repetitive mild concussive brain injuries in mice.

    abstract:BACKGROUND:Although previous evidence suggests that the cognitive effects of concussions are cumulative, the effect of time interval between repeat concussions is largely unknown. OBJECTIVE:To determine the effect of time interval between repeat concussions on the cognitive function of mice. METHODS:We used a weight-...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e318265a439

    authors: Meehan WP 3rd,Zhang J,Mannix R,Whalen MJ

    更新日期:2012-10-01 00:00:00

  • Stereotactic 125iodine brachytherapy for the treatment of singular brain metastases: closing a gap?

    abstract:BACKGROUND:Brain metastases represent the most common intracranial tumors and are associated with very poor prognosis. OBJECTIVE:To investigate the feasibility, survival, and cerebral disease control of patients with singular brain metastases treated with stereotactic 125iodine brachytherapy (SBT), to identify prognos...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e31820b526a

    authors: Ruge MI,Suchorska B,Maarouf M,Runge M,Treuer H,Voges J,Sturm V

    更新日期:2011-05-01 00:00:00

  • International subarachnoid aneurysm trial 2009: endovascular coiling of ruptured intracranial aneurysms has no significant advantage over neurosurgical clipping.

    abstract::In the May 2009 issue of The Lancet Neurology, the 5-year follow-up results of the International Subarachnoid Aneurysm Trial (ISAT) were published. The authors concluded that, although the significant difference between coiling and neurosurgical clipping of ruptured intracranial aneurysms in terms of death and severe ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000368152.67151.73

    authors: Bakker NA,Metzemaekers JD,Groen RJ,Mooij JJ,Van Dijk JM

    更新日期:2010-05-01 00:00:00

  • Cord compression secondary to cervical disc herniation associated with calcification of the ligamentum flavum: case report.

    abstract:OBJECTIVE AND IMPORTANCE:Calcification of the ligamentum flavum is a rare disease that occurs almost exclusively in elderly Japanese people. We report the case of a young Caucasian woman who presented with a C5-C6 disc herniation associated with a cervical calcified ligamentum flavum. CLINICAL PRESENTATION:The patient...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200103000-00047

    authors: Ugarriza LF,Cabezudo JM,Porras LF,Rodríguez-Sánchez JA

    更新日期:2001-03-01 00:00:00

  • In vitro study of biomechanical behavior of anterior and transforaminal lumbar interbody instrumentation techniques.

    abstract:OBJECTIVE:To study the biomechanical behavior of lumbar interbody instrumentation techniques using titanium cages as either transforaminal lumbar interbody fusion (TLIF) or anterior lumbar interbody fusion (ALIF), with and without posterior pedicle fixation. METHODS:Six fresh-frozen lumbar spines (L1-L5) were loaded w...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000245609.01732.E4

    authors: Niemeyer TK,Koriller M,Claes L,Kettler A,Werner K,Wilke HJ

    更新日期:2006-12-01 00:00:00

  • Sir Victor Horsley (1857-1916): pioneer of neurological surgery.

    abstract::Immortalized in surgical history for the introduction of "antiseptic wax," Sir Victor Horsley played a pivotal role in shaping the face of standard neurosurgical practice. His contributions include the first laminectomy for spinal neoplasm, the first carotid ligation for cerebral aneurysm, the curved skin flap, the tr...

    journal_title:Neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1097/00006123-200203000-00032

    authors: Tan TC,Black PM

    更新日期:2002-03-01 00:00:00