Cell Therapy for Stroke: A Mechanistic Analysis.


:Cell therapy has been widely recognized as a promising strategy to enhance recovery in stroke survivors. However, despite an abundance of encouraging preclinical data, successful clinical translation remains elusive. As the field continues to advance, it is important to reexamine prior clinical trials in the context of their intended mechanisms, as this can inform future preclinical and translational efforts. In the present work, we review the major clinical trials of cell therapy for stroke and highlight a mechanistic shift between the earliest studies, which aimed to replace dead and damaged neurons, and later ones that focused on exploiting the various neuromodulatory effects afforded by stem cells. We discuss why both mechanisms are worth pursuing and emphasize the means through which cell replacement can still be achieved.






Gu BJ,Kung DK,Chen HI




Has Abstract


2020-12-28 00:00:00








  • Distribution of angiographic vasospasm after subarachnoid hemorrhage: implications for diagnosis by transcranial Doppler ultrasonography.

    abstract::A study was undertaken to determine how frequently angiographic vasospasm occurs outside the normal access range of transcranial Doppler ultrasound in patients who have suffered a subarachnoid hemorrhage. Vasospasm located in the basal vessels is readily identifiable using transcranial Doppler ultrasound whereas spasm...


    pub_type: 杂志文章


    authors: Newell DW,Grady MS,Eskridge JM,Winn HR

    更新日期:1990-10-01 00:00:00

  • Alterations in Cortical Thickness and Subcortical Volume are Associated With Neurological Symptoms and Neck Pain in Patients With Cervical Spondylosis.

    abstract:BACKGROUND:Advanced cervical spondylosis (CS) can cause structural damage to the spinal cord resulting in long-term neurological impairment including neck pain and motor weakness. We hypothesized long-term structural reorganization within the brain in patients with CS. OBJECTIVE:To explore the associations between cor...


    pub_type: 杂志文章


    authors: Woodworth DC,Holly LT,Mayer EA,Salamon N,Ellingson BM

    更新日期:2019-03-01 00:00:00

  • Flow Diversion for Treatment of Intracranial Aneurysms in Pediatric Patients: Multicenter Case Series.

    abstract:BACKGROUND:Though the Pipeline Embolization Device (Medtronic) is approved for use in adults 22 yr and older, the high efficacy and long-term durability of the device is attractive for treatment of intracranial aneurysms in younger patients who often have aneurysms less amenable to traditional endovascular treatments. ...


    pub_type: 杂志文章,多中心研究


    authors: Cherian J,Srinivasan V,Froehler MT,Grossberg JA,Cawley CM,Hanel RA,Puri A,Dumont T,Ducruet AF,Albuquerque F,Arthur A,Cheema A,Spiotta A,Anadani M,Lopes D,Saied A,Kim L,Kelly CM,Chen PR,Mocco J,De Leacy R,Powers

    更新日期:2020-07-01 00:00:00

  • Sensory and motor interhemispheric integration after section of different portions of the anterior corpus callosum in nonepileptic patients.

    abstract:OBJECTIVE:We evaluated somatosensory and motor interhemispheric integration in four patients who underwent transection of different portions of the anterior corpus callosum (CC) for removal of an intraventricular cyst. The study goal was to relate their performances to the topographical organization of the CC. METHODS...


    pub_type: 杂志文章


    authors: Caillé S,Sauerwein HC,Schiavetto A,Villemure JG,Lassonde M

    更新日期:2005-07-01 00:00:00

  • The silent loss of neuronavigation accuracy: a systematic retrospective analysis of factors influencing the mismatch of frameless stereotactic systems in cranial neurosurgery.

    abstract:BACKGROUND:Neuronavigation has become an intrinsic part of preoperative surgical planning and surgical procedures. However, many surgeons have the impression that accuracy decreases during surgery. OBJECTIVE:To quantify the decrease of neuronavigation accuracy and identify possible origins, we performed a retrospectiv...


    pub_type: 杂志文章


    authors: Stieglitz LH,Fichtner J,Andres R,Schucht P,Krähenbühl AK,Raabe A,Beck J

    更新日期:2013-05-01 00:00:00

  • Rare Variants in Cardiomyopathy Genes Associated With Stress-Induced Cardiomyopathy.

    abstract:BACKGROUND:Stress-induced cardiomyopathy (SIC) is a poorly understood condition associated with periods of emotional and physical stress. The clinical approaches for management of SIC are supportive and reactive to patient symptoms. OBJECTIVE:To utilize next-generation exome sequencing to define genetic variation asso...


    pub_type: 杂志文章


    authors: Kalani MY,Siniard AL,Corneveaux JJ,Bruhns R,Richholt R,Forseth J,Zabramski JM,Nakaji P,Spetzler RF,Huentelman MJ

    更新日期:2016-06-01 00:00:00

  • Liliequist's membrane is a fold of the arachnoid mater: study using sheet plastination and scanning electron microscopy.

    abstract:OBJECTIVE:The subarachnoid space consists of a number of distinct subarachnoid cisterns. They are separated from each other by trabecular walls, one of which is Liliequist's membrane. The aim of this study was to investigate the anatomic characteristics of Liliequist's membrane. METHODS:The study used a combined appro...


    pub_type: 杂志文章


    authors: Zhang M,An PC

    更新日期:2000-10-01 00:00:00

  • Defining Glioblastoma Resectability Through the Wisdom of the Crowd: A Proof-of-Principle Study.

    abstract:BACKGROUND:Extent of resection (EOR) correlates with glioblastoma outcomes. Resectability and EOR depend on anatomical, clinical, and surgeon factors. Resectability likely influences outcome in and of itself, but an accurate measurement of resectability remains elusive. An understanding of resectability and the factors...


    pub_type: 杂志文章


    authors: Sonabend AM,Zacharia BE,Cloney MB,Sonabend A,Showers C,Ebiana V,Nazarian M,Swanson KR,Baldock A,Brem H,Bruce JN,Butler W,Cahill DP,Carter B,Orringer DA,Roberts DW,Sagher O,Sanai N,Schwartz TH,Silbergeld DL,Sisti M

    更新日期:2017-04-01 00:00:00

  • Therapeutic modalities for the management of cerebral vasospasm: timing of endovascular options.

    abstract:OBJECTIVES:To determine if a window of time could be defined during which angioplasty would be most effective in reversing neurological decline and ultimately improving outcome. METHODS:Of a group of 466 patients, 93 underwent endovascular management of clinical vasospasm that was medically refractory. Eighty-four of ...


    pub_type: 杂志文章


    authors: Rosenwasser RH,Armonda RA,Thomas JE,Benitez RP,Gannon PM,Harrop J

    更新日期:1999-05-01 00:00:00

  • Ruptured arteriovenous malformation in the auditory nerve: technical case report.

    abstract:OBJECTIVE AND IMPORTANCE:Arteriovenous malformations in the cranial nerves are very rare, and only one case has been reported in the literature. To our knowledge, this is the first case report of an arteriovenous malformation in the auditory nerve. CLINICAL PRESENTATION:A 30-year-old woman presented with a subarachnoi...


    pub_type: 杂志文章


    authors: Oya S,Matsui T,Asai A

    更新日期:2005-06-01 00:00:00

  • Meningioma with intracerebral hematoma.

    abstract::A case of spontaneous intracranial hemorrhage associated with a meningioma is presented. Intracranial hemorrhage has been reported to be associated with meningioma in 45 cases. A comprehensive review of the subject is presented. The importance of the diagnosis of associated hemorrhage and subsequent surgical intervent...


    pub_type: 杂志文章


    authors: Kohli CM,Crouch RL

    更新日期:1984-08-01 00:00:00

  • Leptomeningeal cyst resulting from adulthood trauma: case report.

    abstract::The authors report a rare sequelae of a skull fracture in an adult, a leptomeningeal cyst. A unique method for repairing this defect is described as well. ...


    pub_type: 杂志文章


    authors: Halliday AL,Chapman PH,Heros RC

    更新日期:1990-01-01 00:00:00

  • Thrombectomy Technique Predicts Outcome in Posterior Circulation Stroke-Insights from the STAR Collaboration.

    abstract:BACKGROUND:Randomized controlled trials evaluating mechanical thrombectomy (MT) for acute ischemic stroke predominantly studied anterior circulation patients. Both procedural and clinical predictors of outcome in posterior circulation patients have not been evaluated in large cohort studies. OBJECTIVE:To investigate t...


    pub_type: 杂志文章


    authors: Alawieh AM,Eid M,Anadani M,Sattur M,Maier IL,Feng W,Goyal N,Starke RM,Rai A,Fargen KM,Psychogios MN,De Leacy R,Grossberg JA,Keyrouz SG,Dumont TM,Kan P,Lena J,Liman J,Arthur AS,Elijovich L,Mccarthy DJ,Saini V,W

    更新日期:2020-10-15 00:00:00

  • Determination of the minimum improvement in pain, disability, and health state associated with cost-effectiveness: introduction of the concept of minimum cost-effective difference.

    abstract:BACKGROUND:Minimum clinical important difference (MCID) has been adopted as the smallest improvement in patient-reported outcome needed to achieve a level of improvement thought to be meaningful to patients. OBJECTIVE:To use a common MCID calculation method with a cost-utility threshold anchor to introduce the concept...


    pub_type: 杂志文章


    authors: Parker SL,McGirt MJ

    更新日期:2015-03-01 00:00:00

  • Impairment of motor recovery after late nerve suture: experimental study in the rabbit. Part 1: functional and electromyographic findings.

    abstract::To study the motor recovery after increasingly late nerve suture, we severed 75 rabbit peroneal nerves and reanastomosed them by microsurgical epineural technique after a delay of up to 12 months. Functional, electromyographic, and morphological parameters were used to evaluate the quality of motor function 6 months a...


    pub_type: 杂志文章


    authors: Richter HP

    更新日期:1982-01-01 00:00:00

  • Papillary tumors of the pineal region: case report.

    abstract:OBJECTIVE:The pineal region is a rare intracranial site for metastasis. We report three patients initially considered to have metastatic papillary adenocarcinoma to the pineal region. On review, these papillary, keratin-positive neoplasms meet the criteria for papillary tumor of the pineal region (PTPR). CLINICAL PRES...


    pub_type: 杂志文章


    authors: Dagnew E,Langford LA,Lang FF,DeMonte F

    更新日期:2007-05-01 00:00:00

  • The use of susceptibility-weighted imaging as an indicator of retrograde leptomeningeal venous drainage and venous congestion with dural arteriovenous fistula: diagnosis and follow-up after treatment.

    abstract:BACKGROUND:Retrograde leptomeningeal venous drainage (RLVD) in dural arteriovenous fistulas (DAVFs) is associated with intracerebral hemorrhage and nonhemorrhagic neurological deficits or death. Angiographic evidence of RLVD is a definite indication for treatment, but less invasive methods of identifying RLVD are requi...


    pub_type: 杂志文章


    authors: Nakagawa I,Taoka T,Wada T,Nakagawa H,Sakamoto M,Kichikawa K,Hironaka Y,Motoyama Y,Park YS,Nakase H

    更新日期:2013-01-01 00:00:00

  • Surgical expertise in neurosurgery: integrating theory into practice.

    abstract::: The development of technical skills is a major goal of any neurosurgical training program. Residency programs in North America are focused on achieving an adequate level of training to produce technically competent surgeons. The training requirements and educational environments needed to produce expert surgeons are...


    pub_type: 杂志文章,评审


    authors: Gélinas-Phaneuf N,Del Maestro RF

    更新日期:2013-10-01 00:00:00

  • Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: initial experience in 51 patients.

    abstract:OBJECTIVE:We report the safety and feasibility of using convection-enhanced delivery to administer Cotara (Peregrine Pharmaceuticals, Inc., Tustin, CA), a novel radioimmunotherapeutic agent, to patients with malignant glioma. METHODS:Between April 1998 and November 2002, 51 patients with histologically confirmed malig...


    pub_type: 杂志文章,多中心研究


    authors: Patel SJ,Shapiro WR,Laske DW,Jensen RL,Asher AL,Wessels BW,Carpenter SP,Shan JS

    更新日期:2005-06-01 00:00:00

  • Real-time atlas-based stereotactic neuronavigation.

    abstract:BACKGROUND:Surgery for tumors in eloquent brain faces immense challenges when attempting to maximize resection and avoid neurological deficits. OBJECTIVE:In order to give the surgeon real-time atlas-based anatomic information linked to the patient's anatomy, we developed a software-based interface between deformable a...


    pub_type: 杂志文章


    authors: Vabulas M,Kumar VA,Hamilton JD,Martinez JJ,Rao G,Sawaya R,Prabhu SS

    更新日期:2014-01-01 00:00:00

  • Saccular intracranial aneurysm disease: distribution of site, size, and age suggests different etiologies for aneurysm formation and rupture in 316 familial and 1454 sporadic eastern Finnish patients.

    abstract:OBJECTIVE:Finnish saccular intracranial aneurysm (sIA) disease associates to 2q33, 8q11, and 9p21 loci and links to 19q13, Xp22, and kallikrein cluster in sIA families. Detailed phenotyping of familial and sporadic sIA disease is required for fine mapping of the Finnish sIA disease. METHODS:Eastern Finland, which is p...


    pub_type: 杂志文章


    authors: Huttunen T,von und zu Fraunberg M,Frösen J,Lehecka M,Tromp G,Helin K,Koivisto T,Rinne J,Ronkainen A,Hernesniemi J,Jääskeläinen JE

    更新日期:2010-04-01 00:00:00

  • Recurrent subarachnoid hemorrhage from untreated ruptured vertebrobasilar dissecting aneurysms.

    abstract::The clinical characteristics of vertebrobasilar dissecting aneurysms occurring with subarachnoid hemorrhage (SAH) were reviewed in 42 patients, with particular focus on the time, incidence, and outcome in association with subsequent rupture. Twenty-nine patients underwent 31 surgical procedures, and the remaining 13 p...


    pub_type: 杂志文章


    authors: Mizutani T,Aruga T,Kirino T,Miki Y,Saito I,Tsuchida T

    更新日期:1995-05-01 00:00:00

  • Treatment of subaxial cervical spinal injuries.

    abstract:UNLABELLED:SUBAXIAL CERVICAL FACET DISLOCATION INJURIES: STANDARDS:There is insufficient evidence to recommend treatment standards. GUIDELINES:There is insufficient evidence to recommend treatment guidelines. OPTIONS:Closed or open reduction of subaxial cervical facet dislocation injuries is recommended. Treatment o...


    pub_type: 杂志文章,评审


    authors: Hadley MN,Walters BC,Grabb PA,Oyesiku NM,Przybylski GJ,Resnick DK,Ryken TC

    更新日期:2002-03-01 00:00:00

  • When the air hits your brain: cerebral autoregulation of brain oxygenation during aerobic exercise allows transient hyperoxygenation: case report.

    abstract:OBJECTIVE:Cerebral autoregulation maintains a relatively stable cerebral blood flow over a range of perfusion pressures. During exercise, regional cerebral blood flow may be elevated in particular areas of the brain. This case report presents the impact of aerobic exercise on intracranially measured pressure and brain ...


    pub_type: 杂志文章


    authors: Bollo RJ,Williams SC,Peskin CS,Samadani U

    更新日期:2010-08-01 00:00:00

  • Deep Brain Stimulation for Parkinson Disease Does not Worsen or Improve Postural Instability: A Prospective Cohort Trial.

    abstract:BACKGROUND:Falls and postural instability (PI) are major sources of morbidity in Parkinson disease (PD). Deep brain stimulation (DBS) is a major therapy for PD. The effects of DBS on PI and falls remain controversial. OBJECTIVE:To study if DBS worsens PI, validated measures of PI (Timed Up and Go, Berg Balance Scale, ...


    pub_type: 临床试验,杂志文章


    authors: Brandmeir NJ,Brandmeir CL,Carr D,Kuzma K,McInerney J

    更新日期:2018-12-01 00:00:00

  • Extracranial-intracranial (EC-IC) arterial bypass: past performance and current concepts.

    abstract::The authors present a review of published experience with intracranial-extracranial arterial bypass grafting. The procedure is technically feasible and has a relatively low morbidity and mortality when performed by experienced microvascular surgeons. However, its therapeutic value is still unproven. ...


    pub_type: 杂志文章


    authors: Samson DS,Boone S

    更新日期:1978-07-01 00:00:00

  • Chiari I malformation with traumatic syringomyelia and spontaneous resolution: case report and literature review.

    abstract::A case history of a 28-year-old woman who sustained a moderately severe head injury and then developed acute bilateral arm weakness is presented. Magnetic resonance imaging studies revealed a Chiari I malformation with a large cervical syringomyelia (hydromyelia). The patient's arm weakness almost completely resolved ...


    pub_type: 杂志文章,评审


    authors: Olivero WC,Dinh DH

    更新日期:1992-05-01 00:00:00

  • Effect of moderate hypothermia on experimental severe subarachnoid hemorrhage, as evaluated by apparent diffusion coefficient changes.

    abstract:OBJECTIVE:The aims of this study were to investigate the early changes in the mean apparent diffusion coefficient (ADC) after severe subarachnoid hemorrhage (SAH), as a marker of ischemic damage, and to examine the effects of moderate hypothermia, induced at various time points, on ADC changes. METHODS:ADC maps were c...


    pub_type: 杂志文章


    authors: Piepgras A,Elste V,Frietsch T,Schmiedek P,Reith W,Schilling L

    更新日期:2001-05-01 00:00:00

  • Emergency neurosurgical care solutions: acute care surgery, regionalization, and the neurosurgeon: results of the 2008 CNS consensus session.

    abstract:OBJECTIVE:Organized general surgery has recently proposed creation of a new acute care surgery subspecialty to include emergency care of basic neurosurgical and orthopedic surgical problems. Little is known about neurosurgical attitudes toward this proposal and alternative methods of improving access to emergency neuro...


    pub_type: 共识发展会议,杂志文章


    authors: Byrne RW,Bagan BT,Bingaman W,Anderson VC,Selden NR

    更新日期:2011-04-01 00:00:00

  • Techniques for the ventral correction of postsurgical cervical kyphotic deformity.

    abstract::Progressive kyphotic deformity of the cervical spine may be a late sequela of congenital cervical anomalies, degenerative disc disease, neoplasm, cervical trauma, and surgical procedures. Of these, postsurgical kyphosis is the most common and can occur after ventral and dorsal surgeries of the cervical spine. The purp...


    pub_type: 杂志文章


    authors: Stewart TJ,Steinmetz MP,Benzel EC

    更新日期:2005-01-01 00:00:00