Cell Therapy for Stroke: A Mechanistic Analysis.

Abstract:

:Cell therapy has been widely recognized as a promising strategy to enhance recovery in stroke survivors. However, despite an abundance of encouraging preclinical data, successful clinical translation remains elusive. As the field continues to advance, it is important to reexamine prior clinical trials in the context of their intended mechanisms, as this can inform future preclinical and translational efforts. In the present work, we review the major clinical trials of cell therapy for stroke and highlight a mechanistic shift between the earliest studies, which aimed to replace dead and damaged neurons, and later ones that focused on exploiting the various neuromodulatory effects afforded by stem cells. We discuss why both mechanisms are worth pursuing and emphasize the means through which cell replacement can still be achieved.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Gu BJ,Kung DK,Chen HI

doi

10.1093/neuros/nyaa531

subject

Has Abstract

pub_date

2020-12-28 00:00:00

eissn

0148-396X

issn

1524-4040

pii

6054569

pub_type

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