Abstract：
:The developmental expression of gonadotropin-releasing hormone receptor (GnRH-R) and its splice variants was examined in the gonads of tammar wallaby pouch young in order to elucidate the functional role of GnRH-R in the developing testis and ovary. Wallaby GnRH-R, like eutherian GnRH-Rs, contains three exons and two introns. In the present study, the transcripts of two splice variants (GnRH-R Delta 1 and GnRH-R Delta 2) were cloned from the pituitary. GnRH-R Delta 1 contained a 291 bp deletion from nucleotide positions 232 to 522 within exon 1. This transcript appears to be distinctive in the wallaby and has not been reported in other species. GnRH-R Delta 2 contained a 220 bp deletion from nucleotide positions 523 to 742, corresponding to exon 2. We examined the subcellular localization of the wild type GnRH-R and its splice variants with confocal microscopy, showing that both the wild type receptor and the splice variants were membrane-associated molecules. The different pattern of expression of the wild type receptor and the variants transcripts found in adult and neonatal tissues suggests a specific developmental regulation of the GnRH-R Delta 2 transcript. In addition, the developmental expression of the GnRH-R and GnRH-R Delta 1 transcripts showed a possible association with key physiological events during gonadal development in the wallaby pouch young, suggesting that GnRH-R may be involved in the regulation of early development in the testis and ovary.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Cheung TC,Hearn JPdoi
10.1016/s0016-6480(03)00146-1keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
88-99issue
1eissn
0016-6480issn
1095-6840pii
S0016648003001461journal_volume
133pub_type
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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