Abstract：
:The differential impact of stress on brain functions of males and females has been widely observed in vertebrates. Recent evidence suggests that stress-induced glucocorticoid signaling affects sexual differentiation and sex changes in teleost fish. These facts led us to postulate that there were sex differences in glucocorticoid signaling in the teleost brain that underlie some sex differences in their physiological and behavioral traits. Here we found sexually dimorphic expression of a glucocorticoid receptor gene (gr1) in the brain of medaka fish (Oryzias latipes), with females having greater expression in several preoptic and thalamic nuclei. Further, gr1 exhibits female-biased expression in neurons of the anterior parvocellular preoptic nucleus that produce the neuropeptides vasotocin and gonadotropin-releasing hormone 1 (these neuropeptides have been implicated in the regulation of neuroendocrine and behavioral functions). These findings suggest that glucocorticoids have a greater influence on physiology and behavior mediated by these neuropeptides in females than in males, which may contribute to sex differences in the brain's response to stress.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Kikuchi Y,Hosono K,Yamashita J,Kawabata Y,Okubo Kdoi
10.1016/j.ygcen.2015.09.031subject
Has Abstractpub_date
2015-11-01 00:00:00pages
47-53eissn
0016-6480issn
1095-6840pii
S0016-6480(15)00275-0journal_volume
223pub_type
杂志文章abstract：:Intraperitoneal injection of rainbow trout (Salmo gairdneri) with 0.4 microgram/g of human growth hormone (hGH) increased plasma levels of 3,5,3'-triiodo-L-thyronine (T3) and Vmax of the hepatic microsomal 5'-monodeiodinase enzyme (5'D) that converts thyroxine (T4) to T3, with no effect on Km or plasma T4 levels. A do...
journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
doi：10.1016/0016-6480(88)90005-6
更新日期：1988-02-01 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
doi：10.1006/gcen.1994.1164
更新日期：1994-10-01 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章,评审
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更新日期：2005-05-15 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
doi：10.1016/j.ygcen.2011.02.027
更新日期：2011-05-01 00:00:00
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
pub_type： 杂志文章,评审
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
doi：10.1006/gcen.1994.1043
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journal_title：General and comparative endocrinology
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pub_type： 杂志文章
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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更新日期：2010-08-01 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
doi：10.1006/gcen.1997.6970
更新日期：1997-11-01 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
doi：10.1006/gcen.1997.6996
更新日期：1998-01-01 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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更新日期：1999-07-01 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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更新日期：1998-02-01 00:00:00
