Sequence analysis, endocrine regulation, and signal transduction of GnRH receptors in teleost fish.

Abstract:

:Three gonadotropin-releasing hormones (GnRHs) and three cognate receptors have been identified in vertebrates, with distinct distributions and functions. According to their sequences, the receptors can be grouped into distinct classes: types I, II, and III. One branch contains all type-I GnRH receptors (GnRH-R-I) from mammals and fish; another branch clusters mainly amphibian and human type-II GnRH receptors; and a third branch includes evolved fish, mainly perciform species, type-III GnRH receptors. Taken tilapia GnRH receptors as a model, the present study summarizes the information regarding the amino-acid residues assumed to be involved in the receptors' structure, binding, activation, and intracellular signal transduction, including arrangement of the disulfide bonds, glycosylation sites, coupling to G proteins, and protein kinase A or protein kinase C phosphorylation sites.

journal_name

Gen Comp Endocrinol

authors

Levavi-Sivan B,Avitan A

doi

10.1016/j.ygcen.2005.01.019

keywords:

subject

Has Abstract

pub_date

2005-05-15 00:00:00

pages

67-73

issue

1-2

eissn

0016-6480

issn

1095-6840

pii

S0016-6480(05)00031-6

journal_volume

142

pub_type

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