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Effect of cortisol on the in vitro hepatic conversion of thyroxine to triiodothyronine in brook charr (Salvelinus fontinalis Mitchill).

Abstract：

:In vitro studies with liver homogenates of brook charr (Salvelinus fontinalis) demonstrate that the conversion of thyroxine (T4) to triiodothyronine (T3) is dependent upon temperature, pH, substrate, and homogenate concentration, supporting the hypothesis of an enzymatic hepatic T4 to T3 conversion. Dithiothreitol has a marked stimulatory effect on the rate of conversion. The kinetics of the conversion, determined by Lineweaver-Burke analysis suggest a Michaelis-Menten (Km) constant of 1.3 x 10(-8) M, and a maximum velocity (Vmax) of 0.42 pmol/mg protein/h. In brook charr given intraperitoneal implants of hydrogenated coconut oil containing cortisol at levels of 0, 5, and 50 mg/kg body weight, and sampled after 56 days, T4 to T3 conversion by homogenates of hepatic tissue in vitro was significantly (P less than 0.01) higher in the fish implanted with 50 mg/kg of cortisol than in either of the other two groups. However, plasma cortisol, L-thyroxine (T4) and triiodo-L-thyronine (T3) concentrations, plasma T3:T4 ratios and hepatosomatic index were not significantly different in the three treatment groups.

journal_name

Gen Comp Endocrinol

journal_title

General and comparative endocrinology

authors

Vijayan MM,Flett PA,Leatherland JF

doi

10.1016/0016-6480(88)90151-7

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

312-8

issue

2

eissn

0016-6480

issn

1095-6840

pii

0016-6480(88)90151-7

journal_volume

70

pub_type

杂志文章

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