Preparation of collagen-based materials for wound dressing.

Abstract:

OBJECTIVE:To describe the methods which were used to develop collagen-based materials for wound dressing. METHODS:Fresh frozen bovine tendon was treated with 0.05 mol/L acetic acid at pH 3.2 for 48-72 hours, homogenized, filtered, mixed with 8% chondroitin sulphate, for creating a deaerated 1.5%-2.5% collagen solution. The solution was lyophilized in either a pre-frozen or non-pre-frozen mould. The collagen sponge was then cross-linked with 0.25% glutaraldehyde for 24 hours. Three other types of wound dressings were developed using a similar method: collagen membrane with a polyurethane membrane onlay, polyurethane-coated collagen membrane and collagen membrane on gauze. RESULTS:It was demonstrated that the use of frozen bovine tendon was stable, and that the prepared collagen sponge contained pores of 50-400 microm in diameter. CONCLUSIONS:Collagen could be used as wound dressing.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Wu Z,Sheng Z,Sun T,Geng M,Li J,Yao Y,Huang Z

keywords:

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

419-23

issue

3

eissn

0366-6999

issn

2542-5641

journal_volume

116

pub_type

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