Hot spot mutations of hepatitis B virus pre-C/C gene and its promotor in Chinese patients and the clinical implications.

abstract：OBJECTIVE:To investigate the use of the Gibbs-Sampler method in evaluating the relationship between clinic events and health risks in a meta-analysis of multiple clinical trials. METHODS:By using a generalized linear model with random-effects, Gibbs-Sampler technique was used in a meta-analysis of multiple clinical tr...

journal_title：Chinese medical journal

authors： Wang Y,Wang Y,Li L,Wang Z,Macus F,Salim Y

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Subcapital femoral neck fracture in young adults has many complications, and the incidence is increasing year-by-year. The selection of the proper operation method to avoid them is an ambiguous matter. This study aimed to evaluate the treatment effect of subcapital femoral neck fracture by the capsulotomy an...

journal_title：Chinese medical journal

authors： Liu C,Liu MT,Li P,Xu HH

更新日期：2015-02-20 00:00:00

abstract：BACKGROUND:Recently, substrate mapping (SM) has been described to facilitate catheter ablation of stable and unstable ventricular tachycardia (VT) after myocardial infarction. However, SM is time consuming with potential disadvantages of multiple ablation lines such as impairment of ventricular function or proarrhythmi...

journal_title：Chinese medical journal

authors： Li YG,Grönefeld G,Israel C,Lu SB,Wang QS,Meng S,Hohnloser SH

更新日期：2006-07-20 00:00:00

abstract：OBJECTIVE:To study the interruptive effect of hepatitis B virus (HBV) specific immunolobulin (HBIG) before delivery in attempt to prevent intrauterine transmission of HBV. METHODS:Nine hundred and eighty HBsAg carrier pregnant women were randomly divided into HBIG group and control group. Each subject in the HBIG grou...

journal_title：Chinese medical journal

authors： Zhu Q,Yu G,Yu H,Lu Q,Gu X,Dong Z,Zhang X

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Bone grafting is commonly used to repair bone defects. As the porosity of the graft scaffold increases, bone formation increases, but the strength decreases. Early attempts to engineer materials were not able to resolve this problem. In recent years, nanomaterials have demonstrated the unique ability to impr...

journal_title：Chinese medical journal

authors： Tang D,Xu G,Yang Z,Holz J,Ye X,Cai S,Yuan W,Wang Y

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and the clinico-pathological manifestations in patients with immunoglobulin nephropathy (IgAN). METHODS:A flanking primer pair and an insertion-specific primer pair were used to perform two polyme...

journal_title：Chinese medical journal

authors： Chen X,Liu S,Ye Y,Xu Q

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:To explore the methods of lens-sparing (without lensectomy), non-silicone oil tamponade and no scleral buckling for treatment of early giant retinal tears. METHODS:Thirteen cases of early retinal detachment of proliferative vitreoretinopathy (PVR) grade C2-D1, with giant tear extending from 135 degrees to 27...

journal_title：Chinese medical journal

authors： Xu X,Zhang X,Wu N,Ho PC

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:To detect occult metastases in lymph nodes from patients with colorectal carcinoma and its clinical significance. METHODS:The metastases in 260 lymph nodes from 39 histologically verified colorectal cancer patients were studied by both hematoxylin-eosin (HE) staining and cytokeratin-20 (CK20) specific RT-PCR...

journal_title：Chinese medical journal

authors： Liu Z,Ye X,Bi W,Wang M,Li Y,Chen T

更新日期：2002-04-01 00:00:00

abstract：:[This corrects the article DOI: 10.4103/0366-6999.181956.]. ...

journal_title：Chinese medical journal

authors：

更新日期：2016-07-20 00:00:00

abstract：OBJECTIVE:To characterize the mRNA expression of CXC chemokine IL-8, CC chemokine monocyte chemothractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES), and a newly defined DC chemokine DC-CK1 as well as the expression of IL-8 receptor, MCP-1 receptor and RANTES receptor i...

journal_title：Chinese medical journal

authors： Zhu K,Shen Q,Ulrich M,Zheng M

更新日期：2000-12-01 00:00:00

abstract：:Eight strains of sonicated Helicobacter pylori (H. pylori) were pooled as group antigen to detect the serum IgG antibody to H. pylori in patients with various gastroduodenal diseases and subjects at health check-up. The enzyme-linked immunosorbent assay method used had a sensitivity of 94%, a specificity of 87%, and a...

journal_title：Chinese medical journal

authors： Xiao SD,Pan ZJ,Zhang ZH,Jiang SJ

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Since early December 2019, the 2019 novel coronavirus disease (COVID-19) has caused pneumonia epidemic in Wuhan, Hubei province of China. This study aimed to investigate the factors affecting the progression of pneumonia in COVID-19 patients. Associated results will be used to evaluate the prognosis and to f...

journal_title：Chinese medical journal

authors： Liu W,Tao ZW,Wang L,Yuan ML,Liu K,Zhou L,Wei S,Deng Y,Liu J,Liu HG,Yang M,Hu Y

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Epigallocatechin-3-gallate (EGCG) has exhibited antitumor properties in several types of cancers, including nasopharyngeal carcinoma (NPC), but the molecular mechanisms underlying this function remain incompletely understood. The aim of the present study was to characterize the global impact of EGCG on the e...

journal_title：Chinese medical journal

authors： Li BB,Huang GL,Li HH,Kong X,He ZW

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis, but the results from different high TB-endemic countries are different. The aim of this study was to investigate the value of IGRA in the diagnosis of active pulmonary TB (PTB) in China. METHODS:We co...

journal_title：Chinese medical journal

authors： Kang WL,Wang GR,Wu MY,Yang KY,Er-Tai A,Wu SC,Geng SJ,Li ZH,Li MW,Li L,Tang SJ

更新日期：2018-02-05 00:00:00

abstract：BACKGROUND:Anisodamine is widely used in therapy for treating acute glomerulonephritis and diabetic nephropathy because it can improve renal microcirculation. We performed a study to evaluate the preventive effects of anisodamine against contrast-induced nephropathy (CIN) in type 2 diabetics with renal insufficiency un...

journal_title：Chinese medical journal

authors： Geng W,Fu XH,Gu XS,Wang YB,Wang XC,Li W,Jiang YF,Hao GZ,Fan WZ,Xue L

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To investigate the role of AC-cAMP system in the transmission of the action of the growth hormone releasing hormone (GRH) on growth hormone (GH) release in pituitary GH-secreting adenomas. METHODS:The effects of GRH (10(-7) mol/L) on intracellular cAMP levels and GH release and the effects of AC-cAMP stimula...

journal_title：Chinese medical journal

authors： Shi Y,Deng J,Yin J

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), one of the major metabolites from prostaglandin D2 in arachidonic acid metabolic pathway, has potential anti-inflammatory properties. The objective of this study was to explore the effects of 15d-PGJ2-loaded poly(D,L-lactide-co-glycolide) nanocapsules (15d-PGJ2-NC...

journal_title：Chinese medical journal

authors： Tang Q,Chen LL,Wei F,Sun WL,Lei LH,Ding PH,Tan JY,Chen XT,Wu YM

更新日期：2017-02-05 00:00:00

abstract：OBJECTIVE:To investigate the relationship between the presence of the TNF2 allele and plasma concentrations of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptor (sTNF-R) with the development of acute severe pancreatitis (ASP) and severe sepsis. METHODS:Genomic DNA was prepared from peripheral blood leuk...

journal_title：Chinese medical journal

authors： Zhang D,Li J,Jiang Z,Yu B,Tang X,Li W

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Cross-sectional area (CSA) for small pulmonary vessels is considered a parameter of pulmonary vessel alterations in patients with chronic obstructive pulmonary disease. This study was to evaluate the correlation of CSA with airflow obstruction parameters in asthma. Furthermore, we aimed to measure the differ...

journal_title：Chinese medical journal

authors： Wang J,Li MJ,Chang C

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the effects of long-term exposure to traffic-related air pollution on lung function, airway inflammation, and respiratory symptoms. METHODS:We enrolled 1003 residents aged 57.96 ± 8.99 years livi...

journal_title：Chinese medical journal

authors： Hu ZW,Zhao YN,Cheng Y,Guo CY,Wang X,Li N,Liu JQ,Kang H,Xia GG,Hu P,Zhang PJ,Ma J,Liu Y,Zhang C,Su L,Wang GF

更新日期：2016-09-20 00:00:00

abstract：BACKGROUND:Pancreatic cancer is a highly malignant tumor affecting an ever increasing number of patients with a mean 5-year survival rate below 4%. Therefore, gene therapy for cancer has become a potential novel therapeutic modality. In this study we sought to determine the inhibitory effects of adenovirus-mediated hum...

journal_title：Chinese medical journal

authors： Pan XT,Zhu QY,Li DC,Yang JC,Zhang ZX,Zhu XG,Zhao H

更新日期：2008-10-20 00:00:00

abstract：OBJECTIVE:The objective was to provide a brief history of J wave syndromes and to summarize our current understanding of their molecular, ionic, cellular mechanisms, and clinical features. We will also discuss the existing debates and further direction in basic and clinical research for J wave syndromes. DATA SOURCES:...

journal_title：Chinese medical journal

authors： Li GL,Yang L,Cui CC,Sun CF,Yan GX

更新日期：2015-04-05 00:00:00

abstract：BACKGROUND:Long-term use of benzalkonium chloride (BAC)-preserved drugs is often associated with ocular surface toxicity. Ocular surface symptoms had a substantial impact on the glaucoma patients' quality of life and compliance. This study aimed to investigate the effects of sodium hyaluronate (SH) on ocular surface to...

journal_title：Chinese medical journal

authors： Liu X,Yu FF,Zhong YM,Guo XX,Mao Z

更新日期：2015-09-20 00:00:00

abstract：BACKGROUND:Tenofovir disoproxil (TDF) is a promising salvage therapy for patients with chronic hepatitis B (CHB) who failed regimens of other nucleoside analogues (NAs). In this study, we aimed to investigate the clinical efficacy and safety of TDF monotherapy in Chinese CHB patients with genotypic resistance. METHODS...

journal_title：Chinese medical journal

authors： Zhou J,Liu YY,Lian JS,Pan LF,Yang JL,Huang JR

更新日期：2017-04-20 00:00:00

abstract：OBJECTIVE:To study the preventive effect of artemether (Art) in protecting the people from schistosome infection during flood fighting in schistosomiasis endemic area of Poyang Lake, Jiangxi Province. METHODS:From mid July to mid August in 1996, the water level in Poyang Lake rose due to torrential rains and 2 embankm...

journal_title：Chinese medical journal

authors： Song Y,Xiao S,Wu W,Zhang S,Xie H,Xu X,Hu X,Cui Q,Chen M,Zheng J

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Distal pancreatectomy traditionally included splenectomy; the spleen, however, is an important organ in the immunologic defense of the host and is worthy of preservation. The aim of this research was to study the feasibility, safety and clinical effects of spleen and splenic vessel-preserving distal pancreat...

journal_title：Chinese medical journal

authors： Ma JP,Chen CQ,Peng L,Zhao G,Cai SR,Hu SX,He YL,Zhan WH

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:To investigate the status of the drug resistance and the ampC gene expression of Enterobacter cloacae. METHODS:Disk diffusion tests were made for detecting the susceptibility of antimicrobial agents against Enterobacter cloacae. AmpC gene was amplified by polymerase chain reaction (PCR) and verified by DNA s...

journal_title：Chinese medical journal

authors： Zhou Z,Li L,Yu Y,Ma Y

更新日期：2003-08-01 00:00:00

abstract：:Dextrocardia is a rare anomaly where the heart is located on the right side of the chest instead of the normal left side. Ablation of atrial fibrillation (AF) with such an inverted anatomy may be challenging for the manipulation of the catheters. Here we report a case of dextrocardia who underwent ablation for persist...

journal_title：Chinese medical journal

authors： Xue ZM,Sang CH,Dong JZ,Ma CS

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:To study mitogen-activated protein kinase (MAPKs) activation in fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) under the stimulation of IL-1 beta, and to elucidate the role of protein tyrosine kinase (PTK) in the activation of MAPKs. METHODS:Primary cultures of RA FLS were used. Western blo...

journal_title：Chinese medical journal

authors： Lu H,Sun T,Yao L,Zhang Y

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:During cardiac arrest, the gastrointestinal tract is sensitive to ischemia. Protection of the gastrointestinal tract is a critical factor in determining prognosis following cardiopulmonary resuscitation (CPR). This study seeks to determine the extent of gastrointestinal tract injury and the potential protect...

journal_title：Chinese medical journal

authors： Lu Y,Wang S,Li CS

更新日期：2012-12-01 00:00:00