Temperospatial expression of matrix metalloproteinases 1, 2, 3, and 9 during early tooth development.

Abstract:

:Odontogenesis involves a complex series of processes including epithelial-mesenchymal interactions, morphogenesis, differentiation, fibrillogenesis, and mineralization. Extracellular (ECM) remodeling plays a critical role in the rapid morphological changes that accompany these events. It is proposed that matrix metalloproteinases (MMPs) participate in the remodeling of tooth-specific matrices that accompanies the developmental events. MMPs are zinc-requiring endopeptidases that are centrally involved in the controlled turnover of ECM components and are key to a varied range of developmental processes. Thus, the aim of this study was to examine the expression of MMPs 1, 2, 3, and 9 within the developing tooth germ of Wistar rats, using immunohistochemical localisation. During the bud stage, MMPs 1, 2, 3, and 9 were expressed within both epithelial and mesenchymal cells. Later on, during the cap stage, differential expression was observed; of note was the expression of MMP 3 within the enamel knot. This study reports the temperospatial expression of MMPs 1, 2, 3, and 9 during early tooth development, and points to them having a key role during this important developmental period.

journal_name

Connect Tissue Res

authors

Randall LE,Hall RC

doi

10.1080/03008200290000538

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

205-11

issue

2-3

eissn

0300-8207

issn

1607-8438

journal_volume

43

pub_type

杂志文章
  • Joint immobilization induced hypoxic and inflammatory conditions in rat knee joints.

    abstract::The purpose of this study was to examine the hypoxic and inflammatory conditions after immobilization in the joint capsule of rat knees. The unilateral knee joints of adult male rats were immobilized with an internal fixator (Im group) for 1 day, 3 days, and 1, 2, 4, 8, and 16 weeks. Sham-operated animals had holes dr...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207.2013.786056

    authors: Yabe Y,Hagiwara Y,Suda H,Ando A,Onoda Y,Tsuchiya M,Hatori K,Itoi E

    更新日期:2013-01-01 00:00:00

  • Characterization of a self-associating glycoprotein from bovine ligamentum nuchae exhibiting dual amine oxidase activity.

    abstract::A homogeneous preparation of glycoprotein (apparent molecular weight 34,000) has been isolated from bovine ligamentum nuchae by treatment of the tissue with 5 M guanidine HCl and 2-mercaptoethanol. The preparation exhibits amine oxidase activity which is only marginally inhibited by beta-aminopropionitrile. ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208109152380

    authors: Serafini-Fracassini A,Ventrella G,Griffiths R,Hinnie J

    更新日期:1981-01-01 00:00:00

  • Enamel specific protein kinases and state of phosphorylation of purified amelogenins.

    abstract::Ameloblastic tissue samples from unerupted bone molars were used to prepare subcellular enamel protein kinase preparations, nuclear + plasma membrane, cytosolic and microsomal, and used in in vitro phosphorylation of purified 20 kDa bovine amelogenin in the presence of 32P-ATP. Both cytosolic and microsomal preparatio...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209809017041

    authors: Salih E,Huang JC,Strawich E,Gouverneur M,Glimcher MJ

    更新日期:1998-01-01 00:00:00

  • Identification of genes required for the spontaneous repair of partial-thickness cartilage defects in immature rats.

    abstract:PURPOSE:Our previous study showed that partial-thickness articular cartilage defects (PTCDs) created in immature rats spontaneously healed to resemble normal hyaline cartilage, but that of mature rats did not. To identify molecules involved in the spontaneous cartilage repair observed in this model, gene expression was...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207.2015.1121250

    authors: Ikegawa N,Sasho T,Yamaguchi S,Saito M,Akagi R,Muramatsu Y,Akatsu Y,Fukawa T,Nakagawa K,Nakajima A,Suzuki T,Takahashi K

    更新日期:2016-05-01 00:00:00

  • MicroRNA-155 suppresses the catabolic effect induced by TNF-α and IL-1β by targeting C/EBPβ in rat nucleus pulposus cells.

    abstract:AIM:miR-155 is a pro-inflammatory or anti-inflammatory factor depending on the cell type in which it is expressed. miR-155 controls apoptosis and matrix degradation in nucleus pulposus (NP) cells in vitro. The aim of this study is to explore the effect of miR-155 in vivo and further investigate the mechanism of miR-155...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008207.2018.1483356

    authors: Zhou J,Liang A,Hong J,Sun J,Lin X,Peng Y,Wang X,Sun S,Xiao D,Xu K,Ye W

    更新日期:2019-03-01 00:00:00

  • Functional and molecular changes in colony stimulating factor secretion by osteoblasts.

    abstract::Two populations of primary osteoblasts and the cloned murine osteoblast cell line MC3T3 were activated with osteotropic agents and the conditioned media tested for the presence of macrophage colony stimulating factor (M-CSF). Differences in ability of the three populations to secrete the cytokine as well as in the eff...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208909023884

    authors: Horowitz MC,Einhorn TA,Philbrick W,Jilka RL

    更新日期:1989-01-01 00:00:00

  • Detailed morphology and distribution of gap junction protein associated with cells from the intra-articular disc of the rat temporomandibular joint.

    abstract::The present study details structural aspects of the cells of the rat intra-articular disc (IAD) of the temporomandibular joint. At the light and electron microscope level, the outline of the cells varied, although a number appeared oval/rounded. Ultrastructurally, the cells contained moderate amounts of the intracellu...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:

    authors: Berkovitz BK,Becker D

    更新日期:2003-01-01 00:00:00

  • Studies on the mechanism of hyaluronate lyase action.

    abstract::Hyaluronate lyase from streptococci group A was purified by chromatography on DEAE-Sephadex A-50 and on Biogel P-150, thereby enriching it about 1,000-fold and separating it into two enzyme fractions with the same amino acid composition. The photooxidation of hyaluronate lyase in the presence of methylene blue results...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207509152171

    authors: Greiling H,Stuhlsatz HW,Eberhard T,Eberhard A

    更新日期:1975-01-01 00:00:00

  • Metabotropic glutamate receptor 1 promotes cementoblast proliferation via MAP kinase signaling pathways.

    abstract:PURPOSE/AIM:Glutamate is one of the signaling molecules responsible for transmission in the central nervous system. Periodontal ligament (PDL) cells were recently reported to express metabotropic glutamate receptors (mGluRs). However, the functions of mGluR signaling in PDL cells or PDL-related cells remain largely unk...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008207.2016.1195826

    authors: Kanaya S,Komatsu H,Shimauchi H,Nemoto E

    更新日期:2016-09-01 00:00:00

  • An estimate of the mean length of collagen fibrils in rat tail-tendon as a function of age.

    abstract::A theoretical expression has been derived for the mean collagen fibril length in tendon based on the assumption that collagen fibrils originate in cell surface invaginations and terminate either at some remote cell surface or another collagen fibril bundle. The expression thus determined requires knowledge of the effe...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208909016814

    authors: Craig AS,Birtles MJ,Conway JF,Parry DA

    更新日期:1989-01-01 00:00:00

  • Depolymerization and de-N-acetylation of glycosaminoglycuronans by the action of alkali in the presence of sodium borohydride.

    abstract::Depolymerization of Ch-4-S, Ch-6-S, HA and HP was observed by gel filtration after treatment with 2-10 N NaOH or Ba(OH)2 in the presence of NaBH4 at 80-83 degrees for 1-5 hr. Depolymerized products were isolated after these treatments. 4-Deoxy-alpha-L-threo-4-enohexopyranosyluronic acid residue as the nonreducing end ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207509152343

    authors: Hirano S,Ishigami M,Koga Y

    更新日期:1975-01-01 00:00:00

  • Tissue engineered cartilage integration to live and devitalized cartilage: a study by reflectance mode confocal microscopy and standard histology.

    abstract::This study investigated the in vivo formation of engineering cartilage within living or devitalized cartilage discs using reflectance mode confocal microscopy and conventional light microscopy. Pig articular chondrocytes were suspended in fibrin glue and placed between two cartilage discs. Four experimental groups wer...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200600809935

    authors: Peretti GM,Campo-Ruiz V,Gonzalez S,Randolph MA,Wei Xu J,Morse KR,Roses RE,Yaremchuk MJ

    更新日期:2006-01-01 00:00:00

  • The effects of collagen fragments on the extracellular matrix metabolism of bovine and human chondrocytes.

    abstract::Cartilage matrix degradation generates collagen type II fragments. The objective of this study is to explore the possibility that these collagen fragments may be part of an endogenous metabolic feedback. Initially, collagen fragments were extracted from normal or osteoarthritic cartilage, as part of a matrix fragment ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008200109014250

    authors: Jennings L,Wu L,King KB,Hämmerle H,Cs-Szabo G,Mollenhauer J

    更新日期:2001-01-01 00:00:00

  • Enamel matrix proteins and ameloblast biology.

    abstract::The paper reviews the changes in ameloblast ultrastructure, concomitant with the changes in its functions across the major stages of amelogenesis. It describes the mechanisms associated with the major events in biosynthesis and degradation of the major enamel proteins (amelogenins and tuftelin/enamelins) and with the ...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:10.3109/03008209509013710

    authors: Deutsch D,Catalano-Sherman J,Dafni L,David S,Palmon A

    更新日期:1995-01-01 00:00:00

  • The biology of meniscal pathology in osteoarthritis and its contribution to joint disease: beyond simple mechanics.

    abstract::The meniscal cartilages in the knee function to improve congruity of the medial and lateral femoro-tibial joints and play critical roles in load distribution and joint stability. Meniscal tears of various configurations are one of the most common conditions of the knee and are associated with an increased risk of deve...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:10.1080/03008207.2017.1284824

    authors: Melrose J,Fuller ES,Little CB

    更新日期:2017-01-01 00:00:00

  • Differences in the fibril structure of corneal and tendon collagen. An electron microscopy and X-ray diffraction investigation.

    abstract::A detailed analysis of the D-period and axial electron density distribution of cornea and tendon collagen was carried out by means of X-ray diffraction and electron microscopy. Ultrastructural observations were made on replicas of freeze fractured and deep-etched specimens. Synchrotron radiation was used to obtain hig...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208609001985

    authors: Marchini M,Morocutti M,Ruggeri A,Koch MH,Bigi A,Roveri N

    更新日期:1986-01-01 00:00:00

  • Analysis of osteopontin in mouse growth plate cartilage by application of laser capture microdissection and RT-PCR.

    abstract::Gene expression of osteopontin (OPN) has been investigated in mice by application of laser capture microdissection (LCM) and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. LCM permits individual cells to be isolated ("captured") from tissue sections for molecular analyses. In this study, chondrocyt...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:

    authors: Landis WJ,Jacquet R,Hillyer J,Zhang J

    更新日期:2003-01-01 00:00:00

  • Structural analysis of glycosaminoglycans and proteoglycans by means of Raman microspectrometry.

    abstract::Raman spectra have been determined for hyaluronan, chondroitin-4-sulfate, chondroitin-6-sulfate, aggrecan monomers and aggregates. The nature of the saccharides and the pattern of sulfation can be discerned. There were only small spectral changes with pH and ionic composition. Differences between hydroxyl vibrations, ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200802398422

    authors: Ellis R,Green E,Winlove CP

    更新日期:2009-01-01 00:00:00

  • Biologically formed amorphous calcium carbonate.

    abstract::Many organisms from a wide variety of taxa produce amorphous calcium carbonate (ACC), despite the fact that it is inherently unstable and relatively soluble in its pure state. These properties also make it difficult to detect and characterize ACC. Raman spectroscopy is a particularly useful method for investigating AC...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:

    authors: Weiner S,Levi-Kalisman Y,Raz S,Addadi L

    更新日期:2003-01-01 00:00:00

  • Glycosaminoglycan synthesis by Dupuytren's cells in culture.

    abstract::Glycosaminoglycan synthesis by cells cultured from nodule or band tissues of patients with Dupuytren's disease was compared with that of skin fibroblasts cultured from uninvolved areas of the palm. No differences were observed in culture which could account either for the abnormal glycosaminoglycan content or the incr...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208209160272

    authors: Slack C,Flint MH,Thompson BM

    更新日期:1982-01-01 00:00:00

  • Explant models for meniscus metabolism, injury, repair, and healing.

    abstract::Purpose/Aim: Knee meniscus is a wedge-shaped fibrocartilaginous tissue, playing important roles in maintaining joint stability and function. Injuries to the meniscus, particularly with the avascular inner third zone, hardly heal and frequently progress into structural breakdown, followed by the initiation of osteoarth...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008207.2019.1702031

    authors: Tarafder S,Park G,Lee CH

    更新日期:2020-05-01 00:00:00

  • Cartilage, bone and tooth induction during early embryonic mouse mandibular morphogenesis using serumless, chemically-defined medium.

    abstract::Studies were designed to test the hypothesis that plasma- and serum-deprived embryonic cells and tissues in vitro are capable of producing growth regulating factors which augment cartilage, bone and tooth induction during mouse mandibular process development. Embryonic mouse first branchial arch-derived mandibular pro...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:10.3109/03008209009152421

    authors: Slavkin HC,Sasano Y,Kikunaga S,Bessem C,Bringas P Jr,Mayo M,Luo W,Mak G,Rall L,Snead ML

    更新日期:1990-01-01 00:00:00

  • Two distinctive BMP-carriers induce zonal chondrogenesis and membranous ossification, respectively; geometrical factors of matrices for cell-differentiation.

    abstract::A partially purified BMP preparation was combined with a fibrous glass membrane (FGM) or porous particles of hydroxyapatite (PPHAP), and then implanted subcutaneously into the backs of rats. As a control of these new carriers, a conventional carrier of insoluble bone matrix (IBM) was also used. These new geometrically...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209509013726

    authors: Kuboki Y,Saito T,Murata M,Takita H,Mizuno M,Inoue M,Nagai N,Poole AR

    更新日期:1995-01-01 00:00:00

  • Expression analysis of angiogenic growth factors and biological axis CXCL12/CXCR4 axis in idiopathic pulmonary fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is associated with aberrant repair, persistence of collagen deposition, and the development of vascular remodeling. However, the role of angiogenesis in the pathogenesis of IPF is still undetermined. The aim of this study was to evaluate the combined mRNA expression of vascular endo...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008200903056150

    authors: Antoniou KM,Soufla G,Lymbouridou R,Economidou F,Lasithiotaki I,Manousakis M,Drositis I,Spandidos DA,Siafakas NM

    更新日期:2010-01-01 00:00:00

  • Modulation of growth factor action by the extracellular matrix.

    abstract::Growth factors were historically defined as molecules produced by the body to regulate cell growth and proliferation. After the identification of their receptors and the intracellular signaling machinery they activate, it is now clear that they are involved in the regulation of multiple processes essential for develop...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:10.1080/03008200802148629

    authors: Oehrl W,Panayotou G

    更新日期:2008-01-01 00:00:00

  • Calcite orientations and composition ranges within teeth across Echinoidea.

    abstract::Sea urchin's teeth from four families of order Echinoida and from orders Temnopleuroida, Arbacioida and Cidaroida were studied with synchrotron X-ray diffraction. The high and very high Mg calcite phases of the teeth, i.e. the first and second stage mineral constituents, respectively, have the same crystallographic or...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207.2014.923865

    authors: Stock SR,Ignatiev K,Lee PL,Almer JD

    更新日期:2014-08-01 00:00:00

  • Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells.

    abstract:UNLABELLED:Keratocystic odontogenic tumors (KCOTs) are locally invasive, rapidly proliferating cystic lesions of the jaw. The bone-invasive nature of these tumors has been previously associated with the expression of matrix metalloproteinases (MMPs), which degrade the extracellular matrix. The purpose of this study was...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207.2014.923875

    authors: Amm HM,Casimir MD,Clark DB,Sohn P,MacDougall M

    更新日期:2014-08-01 00:00:00

  • High-magnitude mechanical strain inhibits the differentiation of bone-forming rat calvarial progenitor cells.

    abstract:PURPOSE:Orthodontic tooth movement occurs during the bone remodeling induced by therapeutic mechanical strain. It is important to investigate the relation between the strength of mechanical stress and bone formation activity. The aim of this study was to determine the effect of high-magnitude mechanical strain on bone ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207.2015.1040878

    authors: Fushiki R,Mayahara K,Ogawa M,Takahashi Y,Karasawa Y,Tsurumachi N,Tamura T,Shimizu N

    更新日期:2015-01-01 00:00:00

  • Alterations of elastin fibrogenesis by inhibition of the formation of desmosine crosslinks. Comparison between the effect of beta-aminopropionitrile (beta-APN) and penicillamine.

    abstract::Experimental lathyrism was induced by feeding newborn chicks a diet containing 0.2 and 0.4% DL-Penicillamine, with or without CuSO4 (10 mg/Kg diet) and Vitamin B6 (100 mg/Kg diet), or 0.015 and 0.1% beta-aminopropionitrile fumarate (beta-APN). After 7, 15, 25 and 55 days of treatment the animals were killed, the aorta...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208509015021

    authors: Ronchetti IP,Contri MB,Fornieri C,Quaglino D Jr,Mori G

    更新日期:1985-01-01 00:00:00

  • Regulation of statoconia mineralization in Aplysia californica in vitro.

    abstract::Statoconia are calcium carbonate inclusions in the lumen of the gravity-sensing organ, the statocyst, of Aplysia californica. The aim of the present study was to examine the role of carbonic anhydrase and urease in statoconia mineralization in vitro. The experiments were performed using a previously described culture ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209609029206

    authors: Pedrozo HA,Schwartz Z,Dean DD,Wiederhold ML,Boyan BD

    更新日期:1996-01-01 00:00:00