Association between the tumor necrosis factor locus and the clinical outcome of Leishmania chagasi infection.

abstract：:The cellular source of interleukin-6 (IL-6) during infection of mice with Listeria monocytogenes was investigated both in vitro and in vivo. Peritoneal cells taken at intervals from infected mice and cultured in vitro without added stimulus produced high titers of IL-6 peaking 2 days postinfection in a time course sim...

journal_title：Infection and immunity

authors： Liu Z,Cheers C

更新日期：1993-06-01 00:00:00

abstract：:Science has always been a competitive undertaking. Despite recognition of the benefits of cooperation and team science, reduced availability of funding and jobs has made science more competitive than ever. Here we consider the benefits of competition in providing incentives to scientists and the adverse effects of com...

journal_title：Infection and immunity

authors： Fang FC,Casadevall A

更新日期：2015-04-01 00:00:00

abstract：:UV-inactivated Sendai virus is mitogenic for murine splenocytes, whereas infectious Sendai virus kills spleen cells in vitro. The isolated hemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins of Sendai virus are also mitogenic for cultured mouse spleen cells. A mixture of these glycoproteins (1 microgram/well...

journal_title：Infection and immunity

authors： Kizaka S,Goodman-Snitkoff G,McSharry JJ

更新日期：1983-05-01 00:00:00

abstract：:In this study we tested the in vitro and in vivo anti-Cryptococcus neoformans activity of an antilaminarin (anti-beta-glucan) monoclonal antibody (MAb 2G8) (immunoglobulin G2b) which was previously shown to inhibit the growth of beta-glucan-exposing Candida albicans cells. Here we show that MAb 2G8 binds to the cell w...

journal_title：Infection and immunity

authors： Rachini A,Pietrella D,Lupo P,Torosantucci A,Chiani P,Bromuro C,Proietti C,Bistoni F,Cassone A,Vecchiarelli A

更新日期：2007-11-01 00:00:00

abstract：:Although nasal vaccination has emerged as an interesting alternative to systemic or oral vaccination, knowledge is scarce about the immune responses after such immunization in humans. In the present study, we have compared the kinetics and organ distribution of the antibody responses after nasal and oral vaccination. ...

journal_title：Infection and immunity

authors： Rudin A,Johansson EL,Bergquist C,Holmgren J

更新日期：1998-07-01 00:00:00

abstract：:Peru-15 is a live attenuated oral vaccine derived from a Vibrio cholerae O1 El Tor Inaba strain by a series of deletions and modifications, including deletion of the entire CT genetic element. Peru-15 is also a stable, motility-defective strain and is unable to recombine with homologous DNA. We wished to determine whe...

journal_title：Infection and immunity

authors： Cohen MB,Giannella RA,Bean J,Taylor DN,Parker S,Hoeper A,Wowk S,Hawkins J,Kochi SK,Schiff G,Killeen KP

更新日期：2002-04-01 00:00:00

abstract：:Differences in acid tolerance among representative oral streptococci were found to be related more closely to the dynamic permeabilities of the bacteria to protons than to differences in the sensitivities of cell membranes to gross damage caused by environmental acidification. For Streptococcus mutans GS-5, Streptococ...

journal_title：Infection and immunity

authors： Bender GR,Sutton SV,Marquis RE

更新日期：1986-08-01 00:00:00

abstract：:Synthetic Escherichia coli lipid A and synthetic S-[2,3-bis-(palmitoyloxy)propyl]-N-palmitoylpentapeptide (tripalmitoyl pentapeptide [TPP]), representing the mitogenically active principles of bacterial lipopolysaccharide (LPS) and lipoprotein, respectively, were compared for their mitogenic activities on splenocytes ...

journal_title：Infection and immunity

authors： Brade L,Bessler WG,Brade H

更新日期：1988-05-01 00:00:00

abstract：:To demonstrate local synthesis of anti-Mycobacterium leprae antibodies, biopsies from skin lesions of leprosy patients were cultured in vitro in a medium containing 14C-labeled lysine and isoleucine, and the culture fluids were analyzed by crossed immunoelectrophoresis with intermediate gel and autoradiography. The re...

journal_title：Infection and immunity

authors： Lai A Fat RF,Chan Pin Jin J,van Furth R,Harboe M

更新日期：1980-02-01 00:00:00

abstract：:The interactions between Klebsiella pneumoniae and the host environment at the site of infection are largely unknown. Pulmonary surfactant serves as an initial point of contact for inhaled bacteria entering the lung and is thought to contain molecular cues that aid colonization and pathogenesis. To gain insight into t...

journal_title：Infection and immunity

authors： Willsey GG,Ventrone S,Schutz KC,Wallace AM,Ribis JW,Suratt BT,Wargo MJ

更新日期：2018-06-21 00:00:00

abstract：:The effect of ingestion of heat-killed Histoplasma capsulatum yeast cells on the metabolism of arachidonic acid (20:4) to prostenoids and leukotrienes was examined in murine peritoneal macrophages (M phi s). H. capsulatum-containing M phi s exhibited a metabolite profile similar to that of zymosan-challenged phagocyte...

journal_title：Infection and immunity

authors： Wolf JE,Massof SE,Peters SP

更新日期：1992-07-01 00:00:00

abstract：:Peptidoglycan from a Staphylococcus epidermidis strain, isolated from a patient with septicemia, was preincubated with human serum. This mixture was then investigated for its potency to induce tumor necrosis factor (TNF) secretion by human blood monocytes. TNF was measured in the supernatants by using a bioassay and/o...

journal_title：Infection and immunity

authors： Mattsson E,Rollof J,Verhoef J,Van Dijk H,Fleer A

更新日期：1994-09-01 00:00:00

abstract：:We have developed an in vitro assay to study the intramacrophage replication of Mycobacterium tuberculosis or Mycobacterium bovis BCG. In this assay, extracellular mycobacterial replication was avoided by using a small infecting inoculum and a new method for efficiently removing nonphagocytocytized bacilli. The abilit...

journal_title：Infection and immunity

authors： Zlotnik A,Crowle AJ

更新日期：1982-08-01 00:00:00

abstract：:Random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of Plasmodium berghei, strain NYU-2, in combination with Corynebacterium parvum and/or living BCG. A high proportion of intravenously immunized mice survived virulent challenge, but subcutaneous vaccination was less effective. Vac...

journal_title：Infection and immunity

authors： Murphy JR,Lefford MJ

更新日期：1978-12-01 00:00:00

abstract：:The relationship between the selective abilities of bacteria to adhere and their predilections for colonizing different mammalian hosts was investigated by using bacteria indigenous to the tongue dorsum of humans and rats as models. Streptococcus salivarius and S. sanguis averaged 22.6 and 2.8%, respectively, of the c...

journal_title：Infection and immunity

authors： Gibbons RJ,Spinell DM,Skobe Z

更新日期：1976-01-01 00:00:00

abstract：:El Tor and non-O1 strains of Vibrio cholerae were analyzed to determine whether synthesis of secreted hemolysin was influenced by the concentration of iron in the medium. Synthesis of hemolysin was found to be iron regulated in both El Tor and non-O1 isolates. Increased levels of hemolytic activity were detected in su...

journal_title：Infection and immunity

authors： Stoebner JA,Payne SM

更新日期：1988-11-01 00:00:00

abstract：:A major ceramide monohexoside (CMH) was purified from lipidic extracts of Cryptococcus neoformans. This molecule was analyzed by high-performance thin-layer chromatography (HPTLC), gas chromatography coupled with mass spectrometry, and fast atom bombardment-mass spectrometry. The cryptococcal CMH is a beta-glucosylcer...

journal_title：Infection and immunity

authors： Rodrigues ML,Travassos LR,Miranda KR,Franzen AJ,Rozental S,de Souza W,Alviano CS,Barreto-Bergter E

更新日期：2000-12-01 00:00:00

abstract：:Vibrio cholerae is the causative bacteria of the diarrheal disease cholera, but it also persists in aquatic environments, where it displays an expression profile that is distinct from that during infection. Upon entry into the host, a tightly regulated circuit coordinates the induction of two major virulence factors: ...

journal_title：Infection and immunity

authors： Hay AJ,Yang M,Xia X,Liu Z,Hammons J,Fenical W,Zhu J

更新日期：2016-12-29 00:00:00

abstract：:Sendai virus hemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins, F and HN, were separated from Triton X-100- or Nonidet P-40-solubilized envelopes as unadsorbed and eluted fractions, respectively, by using glutaralde-hyde-treated chicken erythrocytes. These separated glycoproteins were biologically active. ...

journal_title：Infection and immunity

authors： Hosaka Y

更新日期：1980-10-01 00:00:00

abstract：:Attempts were made to isolate an antigen(s) from Candida albicans suitable for detecting hypersensitivity in a murine model of candidiasis. Using footpad reactivity in cutaneously infected animals as the assay, comparisons were made of two commercial extracts and cell wall and cytoplasmic preparations made in the labo...

journal_title：Infection and immunity

authors： Domer JE,Moser SA

更新日期：1978-04-01 00:00:00

abstract：:Glucose has previously been shown to increase the in vitro phagocytosis of unopsonized Pseudomonas aeruginosa by freshly explanted murine peritoneal macrophages (PM) and cultivated alveolar macrophages (AM). This study examined the effect of glucose on the same phagocytosis process in human AM in order to determine wh...

journal_title：Infection and immunity

authors： Wong SY,Guerdoud LM,Cantin A,Speert DP

更新日期：1999-01-01 00:00:00

abstract：:Vibrio vulnificus causes rapidly progressing septicemia with an extremely high mortality rate (≥50%), even with aggressive antibiotic treatment. The bacteria secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins, which are involved in the pathogenesis of Gram-negative Vibrio species. Recently, we repo...

journal_title：Infection and immunity

authors： Lee TH,Cha SS,Lee CS,Rhee JH,Chung KM

更新日期：2014-11-01 00:00:00

abstract：:Random minitransposon mutagenesis was used to identify genes involved in the survival of Bordetella bronchiseptica within eukaryotic cells. One of the mutants which exhibited a reduced ability to survive intracellularly harbored a minitransposon insertion in a locus (ris) which displays a high degree of homology to tw...

journal_title：Infection and immunity

authors： Jungnitz H,West NP,Walker MJ,Chhatwal GS,Guzmán CA

更新日期：1998-10-01 00:00:00

abstract：:OKM5 antigen and thrombospondin are currently under investigation as potential receptors on the surface of human monocytes, endothelial cells, and melanomas responsible for the cytoadherence of Plasmodium falciparum-infected erythrocytes. We have studies the binding capacity of six human melanoma cell lines and relate...

journal_title：Infection and immunity

authors： Panton LJ,Leech JH,Miller LH,Howard RJ

更新日期：1987-11-01 00:00:00

abstract：:The macrophage has previously been implicated in contributing to the renal inflammation associated with hemolytic-uremic syndrome (HUS). However, there is currently no in vivo model detailing the contribution of the renal macrophage to the kidney disease associated with HUS. Therefore, renal macrophage recruitment and...

journal_title：Infection and immunity

authors： Keepers TR,Gross LK,Obrig TG

更新日期：2007-03-01 00:00:00

abstract：:Previous studies have shown that tumor necrosis factor alpha (TNF-alpha) plays a pathophysiologic role in sepsis induced in rat pups by group B streptococci (GBS). In this model, TNF-alpha is also partially responsible for the induction of interleukin-6 (IL-6). The present study was undertaken to investigate the role ...

journal_title：Infection and immunity

authors： Mancuso G,Tomasello F,Migliardo M,Delfino D,Cochran J,Cook JA,Teti G

更新日期：1994-11-01 00:00:00

abstract：:Cell-mediated immunity plays an important role in immunity to the pathogenic fungus Cryptococcus neoformans. However, the antigen specificity of the T-cell response to C. neoformans remains largely unknown. In this study, we used two approaches to determine the antigen specificity of the T-cell response to C. neoforma...

journal_title：Infection and immunity

authors： Lindell DM,Ballinger MN,McDonald RA,Toews GB,Huffnagle GB

更新日期：2006-08-01 00:00:00

abstract：:Clostridium perfringens is an anaerobic, Gram-positive bacterium that causes a range of diseases in humans, including lethal gas gangrene. We have recently shown that strains of C. perfringens move across the surface of agar plates by a unique type IV pilus (TFP)-mediated social motility that had not been previously d...

journal_title：Infection and immunity

authors： Rodgers K,Arvidson CG,Melville S

更新日期：2011-08-01 00:00:00

abstract：:Intact tissues are relatively resistant to Pseudomonas aeruginosa-induced disease, and injury predisposes tissue to infection. Intact epithelia contain polarized cells that have distinct apical and basolateral membranes with unique lipids and proteins. In this study, the role of cell polarity in epithelial cell suscep...

journal_title：Infection and immunity

authors： Fleiszig SM,Evans DJ,Do N,Vallas V,Shin S,Mostov KE

更新日期：1997-07-01 00:00:00

abstract：:Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GalNAc- and sialic acid-reactive lectins, respectively, were adherent to immobilized secretory immunoglobulin A (IgA) and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge ...

journal_title：Infection and immunity

authors： Ruhl S,Sandberg AL,Cole MF,Cisar JO

更新日期：1996-12-01 00:00:00