Increased vulnerability of dopaminergic neurons in MPTP-lesioned interleukin-6 deficient mice.

abstract：:Quinolinic acid (QA) has been shown to evoke neurotoxic events via NMDA receptor (NMDAR) overactivation and oxidative stress. NMDARs are particularly vulnerable to free radicals, which can modulate protein tyrosine kinase (PTK) and phosphotyrosine phosphatase (PTP) activities. The src family of tyrosine kinases are as...

journal_title：Journal of neurochemistry

authors： Metere A,Mallozzi C,Minetti M,Domenici MR,Pèzzola A,Popoli P,Di Stasi AM

更新日期：2006-06-01 00:00:00

abstract：:Aspartic acid (Asp) undergoes l-isomer-selective efflux transport across the blood-brain barrier (BBB). This transport system appears to play an important role in regulating l- and d-Asp levels in the brain. The purpose of this study was to identify the responsible transporters and elucidate the mechanism for l-isomer...

journal_title：Journal of neurochemistry

authors： Tetsuka K,Takanaga H,Ohtsuki S,Hosoya K,Terasaki T

更新日期：2003-11-01 00:00:00

abstract：:The carbohydrate content of human brain glycoproteins was studied during development from the age of 12 fetal weeks to 8 postnatal months. The concentration of all the glycoprotein monosaccharides increased with age. The total amount of glycoprotein monosaccharides per lipid-free dry tissue increased by about 150% fro...

journal_title：Journal of neurochemistry

authors： Korpeinen T,Mononen I,Krusius T,Järnefelt J

更新日期：1982-12-01 00:00:00

abstract：:We show that the expression of the gene encoding glial fibrillary acidic protein (GFAP) gene is affected by at least three cis-acting elements. A positive regulatory element that is located between nucleotides -1,631 and -1,479 can confer cell type-specific expression on a heterologous gene. A second regulatory elemen...

journal_title：Journal of neurochemistry

authors： Sarkar S,Cowan NJ

更新日期：1991-08-01 00:00:00

abstract：:Major depressive disorder is a severe and chronic illness with high lifetime prevalence and a high incidence of suicide as the cause of death for patients with this diagnosis. Major depressive disorder is often treated with anti-depressants. Although these drugs have been used for many years, their exact mode of actio...

journal_title：Journal of neurochemistry

authors： Gulbins E,Walter S,Becker KA,Halmer R,Liu Y,Reichel M,Edwards MJ,Müller CP,Fassbender K,Kornhuber J

更新日期：2015-07-01 00:00:00

abstract：:The importance of the nuclear receptor nurr1 for the appropriate development of mesencephalic dopamine-synthesizing neurons has been clearly demonstrated through the targeted disruption of the nurr1 gene. The persistence of nurr1 expression in adult tissue suggests a possible role for this transcription factor in the ...

journal_title：Journal of neurochemistry

authors： Sacchetti P,Mitchell TR,Granneman JG,Bannon MJ

更新日期：2001-03-01 00:00:00

abstract：:Stroke is the third leading cause of death as dementia is a main symptom of Alzheimer's disease. One of the important mechanisms in the pathogeny of stroke is free radical production during the reperfusion period, therefore the effects of a type of natural antioxidant, i.e. Crataegus flavonoids (CF), on brain ischemic...

journal_title：Journal of neurochemistry

authors： Zhang DL,Zhang YT,Yin JJ,Zhao BL

更新日期：2004-07-01 00:00:00

abstract：:In the present study, by means of genetic, biochemical, morphological, and electrophysiological approaches, the role of large-conductance voltage- and Ca(2+)-dependent K(+) channels (BK channels) in the release of excitatory and non-excitatory neurotransmitters at hippocampal and non-hippocampal sites has been investi...

journal_title：Journal of neurochemistry

authors： Martire M,Barrese V,D'Amico M,Iannotti FA,Pizzarelli R,Samengo I,Viggiano D,Ruth P,Cherubini E,Taglialatela M

更新日期：2010-10-01 00:00:00

abstract：:Tanycytes are glial cells in the hypothalamus that are functionally part of the blood-brain barrier. They can sense nutrients and metabolites in the circulation such as glucose, then signal to neuronal systems to influence ingestive behaviour and energy storage, and ultimately affect body weight. The complex structure...

journal_title：Journal of neurochemistry

authors： Ebling FJP

更新日期：2020-11-09 00:00:00

abstract：:Disulfide-bridged S100b protein formation, aircatalyzed and induced by thiol/disulfide exchange, was studied under various ionic conditions. As native, physiological disulfide-bridged proteins are obtained easily from their reduced counterparts under appropriate redox conditions, this work was performed to determine w...

journal_title：Journal of neurochemistry

authors： Mely Y,Gérard D

更新日期：1990-10-01 00:00:00

abstract：:The regional distribution and acylation of intraventricularly injected [14C]cadaverine was studied in the rat brain over a 48-h period. The concentrations of labeled cadaverine and its acyl derivatives, N-monoacetylcadaverine and N-monopropionylcadaverine, were determined in the telencephalon, striatum, hypothalamus, ...

journal_title：Journal of neurochemistry

authors： Salzman SK,Stepita-Klauco M

更新日期：1981-11-01 00:00:00

abstract：:Using nuclear reaction 6Li(n, alpha)3H and dielectric detectors, we have studied the distribution of Li in the brain of adult mice, following Li treatment of the animals. Two strains of animals were used in parallel: "quaking" dysmyelinating mutants and normally myelinated controls. The distribution appeared to be sha...

journal_title：Journal of neurochemistry

authors： Heurteaux C,Baumann N,Lachapelle F,Wissocq JC,Thellier M

更新日期：1986-04-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) activates a variety of signaling molecules to exert various functions in the nervous system, including neuronal differentiation, survival, and regulation of synaptic plasticity. Previously, we have suggested that BIT/SHPS-1 (brain immunoglobulin-like molecule with tyrosine-base...

journal_title：Journal of neurochemistry

authors： Araki T,Yamada M,Ohnishi H,Sano SI,Hatanaka H

更新日期：2000-10-01 00:00:00

abstract：:Nigrostriatal neurodegeneration in Parkinson's disease (PD) has been postulated to be caused by various pathological conditions, such as mitochondrial defects, oxidative stress, and ubiquitin-proteasome system (UPS) dysfunction. Pharmacological strategies designed to interfere with these pathological pathways may effe...

journal_title：Journal of neurochemistry

authors： Zhu W,Xie W,Pan T,Jankovic J,Li J,Youdim MB,Le W

更新日期：2008-06-01 00:00:00

abstract：:The myelin transcription factor 1 (Myt1) gene family is comprised of three zinc finger genes [Myt1, Myt1L (Myt1-Like) and NZF3] of the structurally unique CCHHC class that are expressed predominantly in the developing CNS. To understand the mechanism by which this family regulates neural differentiation, we searched f...

journal_title：Journal of neurochemistry

authors： Romm E,Nielsen JA,Kim JG,Hudson LD

更新日期：2005-06-01 00:00:00

abstract：:Manganese is an essential nutrient, integral to proper metabolism of amino acids, proteins and lipids. Excessive environmental exposure to manganese can produce extrapyramidal symptoms similar to those observed in Parkinson's disease (PD). We used in vivo and in vitro models to examine cellular and circuitry alteratio...

journal_title：Journal of neurochemistry

authors： Stanwood GD,Leitch DB,Savchenko V,Wu J,Fitsanakis VA,Anderson DJ,Stankowski JN,Aschner M,McLaughlin B

更新日期：2009-07-01 00:00:00

abstract：:Oxidative stress and free radical damage have been implicated in the neurodegenerative changes characteristic of several neurodegenerative diseases, including Alzheimer's disease. There is experimental evidence that the neurotoxicity of beta-amyloid is mediated via free radicals, and as the deposition of beta-amyloid ...

journal_title：Journal of neurochemistry

authors： Davis DR,Anderton BH,Brion JP,Reynolds CH,Hanger DP

更新日期：1997-04-01 00:00:00

abstract：:Amino acid and monoamine concentrations were examined in tissue extracts of caudate nucleus of genetic substrains of BALB/c mice susceptible or resistant to audiogenic seizures. Amino acids [aspartate, glutamate, glycine, taurine, serine, gamma-aminobutyric acid (GABA)], monoamines, and related metabolites were separa...

journal_title：Journal of neurochemistry

authors： Vriend J,Alexiuk NA,Green-Johnson J,Ryan E

更新日期：1993-04-01 00:00:00

abstract：:In all the species examined thus far, the behavior of microglia during development appears to be highly stereotyped. This reproducibility supports the notion that these cells have a physiological role in development. Microglia are macrophages that migrate from the yolk sac and colonize the central nervous system early...

journal_title：Journal of neurochemistry

authors： Pont-Lezica L,Béchade C,Belarif-Cantaut Y,Pascual O,Bessis A

更新日期：2011-12-01 00:00:00

abstract：:Phosphatidylserine (PS), which is synthesized in mammalian tissues by the exchange between free serine and the nitrogen bases present in membrane glycerophospholipids, is strictly required for protein kinase C (PKC) activity. PKC, as other molecules involved in signal transduction, is present in lipid rafts, considere...

journal_title：Journal of neurochemistry

authors： Buratta S,Felicetti M,Mozzi R

更新日期：2007-11-01 00:00:00

abstract：:Postmortem changes in catecholamines, indoleamines, and their metabolites in rat brain regions following decapitation were determined by LCEC. In the three regions studied neurotransmitter levels declined after decapitation, whereas the metabolite levels increased. Microwave irradiation at 10 kW rapidly inactivated br...

journal_title：Journal of neurochemistry

authors： Ikarashi Y,Sasahara T,Maruyama Y

更新日期：1985-09-01 00:00:00

abstract：:PC12D cells, a new subline of conventional PC12 cells, respond not only to nerve growth factor but also to cyclic AMP by extending their neurites. These cells are flat in shape and are similar in appearance to PC12 cells that have been treated with nerve growth factor for a few days. In both cell lines, we have charac...

journal_title：Journal of neurochemistry

authors： Katoh-Semba R,Oohira A,Sano M,Watanabe K,Kitajima S,Kashiwamata S

更新日期：1989-03-01 00:00:00

abstract：:Recent etiological study in twins (Tanner et al. 1999) strongly suggests that environmental factors play an important role in typical, non-familial Parkinson's disease (PD), beginning after age 50. Epidemiological risk factor analyses of typical PD cases have identified several neurotoxicants, including MPP(+) (the ac...

journal_title：Journal of neurochemistry

authors： Chun HS,Gibson GE,DeGiorgio LA,Zhang H,Kidd VJ,Son JH

更新日期：2001-02-01 00:00:00

abstract：:Dystrobrevin binding protein-1 (dysbindin-1), a candidate gene for schizophrenia, modulates cognition, synaptic plasticity and frontocortical circuitry and interacts with glutamatergic and dopaminergic transmission. Loss of dysbindin-1 modifies cellular trafficking of dopamine (DA) D2 receptors to increase cell surfac...

journal_title：Journal of neurochemistry

authors： Schmieg N,Rocchi C,Romeo S,Maggio R,Millan MJ,Mannoury la Cour C

更新日期：2016-03-01 00:00:00

abstract：:'Metabolism' refers to the vast collection of chemical processes that occur within a living organism. Within this broad designation, one can identify metabolism events that relate specifically to energy homeostasis, whether they occur at the subcellular, cellular, organ, or whole organism level. This review operationa...

journal_title：Journal of neurochemistry

authors： Swerdlow RH

更新日期：2016-10-01 00:00:00

abstract：:Rats were administered [3H]fucose by intracranial injection and synaptic membranes (SMs) isolated 18 h later. Oligosaccharides associated with SM glycoproteins were prepared by hydrazinolysis and analyzed by a combination of affinity chromatography on concanavalin A (Con A)-agarose, ion-exchange chromatography on DEAE...

journal_title：Journal of neurochemistry

authors： Stanojev D,Gurd JW

更新日期：1987-05-01 00:00:00

abstract：:To determine whether prolonged nicotine exposure persistently inactivates rat alpha4beta2 nicotinic receptors expressed in Xenopus oocytes, we measured the voltage-clamped alpha4beta2 response to acetylcholine (ACh) before and 24 h after, 1-h or 12-h incubations in 10 microm nicotine. A 12-h incubation in 10 microm ni...

journal_title：Journal of neurochemistry

authors： Jia L,Flotildes K,Li M,Cohen BN

更新日期：2003-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that represents the most common type of dementia among elderly people. Amyloid beta (Aβ) peptides in extracellular Aβ plaques, produced from the amyloid precursor protein (APP) via sequential processing by β- and γ-secretases, impair hippocampal synaptic plastic...

journal_title：Journal of neurochemistry

authors： Kuwabara Y,Ishizeki M,Watamura N,Toba J,Yoshii A,Inoue T,Ohshima T

更新日期：2014-08-01 00:00:00

abstract：:Melanocortin-4 receptors (MC4 R) are unique among G-protein-coupled receptors (GPCRs) as they have endogenous ligands that can exhibit inverse agonistic properties in the case of elevated basal activity. It is known that the constitutive activity of GPCRs strongly affects the ligand-dependent physiological responses, ...

journal_title：Journal of neurochemistry

authors： Link R,Veiksina S,Tahk MJ,Laasfeld T,Paiste P,Kopanchuk S,Rinken A

更新日期：2020-05-01 00:00:00

abstract：:Cricket (Acheta domesticus) terminal abdominal ganglia (TG) contain high concentrations (approximately 2 pmol/mg protein) of muscarinic and nicotinic cholinergic binding sites, based on the capacity of TG to bind specifically the labelled ligands L-[3H]quinuclidinyl benzilate ([3H]QNB) and [125I]alpha-bungarotoxin ([1...

journal_title：Journal of neurochemistry

authors： Meyer MR,Reddy GR

更新日期：1985-10-01 00:00:00