Abstract:
:The nucleus accumbens is a brain region in which limbic and motor inputs converge. How these information modalities shape accumbens output is not clearly understood. Here, we report that synaptic inputs from the prefrontal cortex and limbic structures interact differently depending on their timing. Coincident inputs may result in enhancing information flow through the nucleus accumbens. Responses to asynchronous inputs are affected by their relative order of arrival, with limbic inputs allowing subsequent prefrontal responses, and prefrontal inputs dampening limbic responses. These mechanisms allow for both coincidence detection and input selection in this integrative brain region.
journal_name
Proc Natl Acad Sci U S Aauthors
Goto Y,O'Donnell Pdoi
10.1073/pnas.202303199keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
13189-93issue
20eissn
0027-8424issn
1091-6490pii
202303199journal_volume
99pub_type
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