Abstract：
:At older ages, the circadian rhythm of body temperature shows a decreased amplitude, an advanced phase, and decreased stability. The present review evaluates to what extent these changes may result from age-related deficiencies at several levels of the thermoregulatory system, including thermoreception, thermogenesis and conservation, heat loss, and central regulation. Whereas some changes are related to the aging process per se, others appear to be secondary to other factors, for which the risk increases with aging, notably a decreased level of fitness and physical activity. Moreover, functional implications of the body temperature rhythm are discussed. For example, the relation between circadian rhythm and thermoregulation has hardly been investigated, while evidence showed that sleep quality is dependent on both aspects. It is proposed that the circadian rhythm in temperature in homeotherms should not be regarded as a leftover of ectothermy in early evolution, but appears to be of functional significance for physiology from the level of molecules to cognition. A new view on the functional significance of the circadian rhythm in peripheral vasodilation and the consequent out-of-phase rhythms in skin and core temperature is presented. It is unlikely that the strong, daily occurring, peripheral vasodilation primarily represents heat loss in response to a lowering of set point, since behavioral measures are simultaneously taken in order to prevent heat loss. Several indications rather point towards a supportive role in immunological host defense mechanisms. Given the functional significance of the temperature rhythm, research should focus on the feasibility and effectiveness of methods that can in principle be applied in order to enhance the weakened circadian temperature rhythm in the elderly.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Van Someren EJ,Raymann RJ,Scherder EJ,Daanen HA,Swaab DFdoi
10.1016/s1568-1637(02)00030-2keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
721-78issue
4eissn
1568-1637issn
1872-9649pii
S1568163702000302journal_volume
1pub_type
杂志文章,评审abstract：:Aging impairs blood vessel function and leads to cardiovascular disease. The mechanisms underlying the age-related endothelial, smooth muscle and extracellular matrix vascular dysfunction are discussed. Vascular dysfunction is caused by: (1) Oxidative stress enhancement. (2) Reduction of nitric oxide (NO) bioavailabil...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2014.10.001
更新日期：2014-11-01 00:00:00
abstract：:Autophagy is a lysosomal degradation process and protective housekeeping mechanism to eliminate damaged organelles, long-lived misfolded proteins and invading pathogens. Autophagy functions to recycle building blocks and energy for cellular renovation and homeostasis, allowing cells to adapt to stress. Modulation of a...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2018.08.004
更新日期：2018-11-01 00:00:00
abstract：:A healthy functioning immune system is critical to stave off infectious diseases, but as humans and other organisms age, their immune systems decline. As a result, diseases that were readily thwarted in early life pose nontrivial harm and can even be deadly in late life. Immunosenescence is defined as the general dete...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.01.011
更新日期：2019-05-01 00:00:00
abstract：:This systematic review and meta-analysis investigates the impact of cognitive training and general mental stimulation on the cognitive and everyday functioning of older adults without known cognitive impairment. We examine transfer and maintenance of intervention effects, and the impact of training in group versus ind...
journal_title：Ageing research reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.arr.2014.02.004
更新日期：2014-05-01 00:00:00
abstract：:Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of ageing appear, c...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2010.08.006
更新日期：2010-11-01 00:00:00
abstract：:The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant c...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2018.01.001
更新日期：2018-03-01 00:00:00
abstract：:It has been well-established that the age-related loss of muscle mass and strength, or sarcopenia, impairs skeletal muscle function and reduces functional performance at a more advanced age. Skeletal muscle satellite cells (SC), as precursors of new myonuclei, have been suggested to be involved in the development of s...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.05.003
更新日期：2009-10-01 00:00:00
abstract：:Both cancer and Alzheimer's disease (AD) are emerging as metabolic diseases in which aberrant/dysregulated glucose metabolism and bioenergetics occur, and play a key role in disease progression. Interestingly, an enhancement of glucose uptake, glycolysis and pentose phosphate pathway occurs in both cancer cells and am...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100915
更新日期：2019-08-01 00:00:00
abstract：:Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused o...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2006.03.006
更新日期：2006-05-01 00:00:00
abstract：:Ageing is manifested as functional and structural deterioration that affects cell and tissue physiology. mRNA translation is a central cellular process, supplying cells with newly synthesized proteins. Accumulating evidence suggests that alterations in protein synthesis are not merely a corollary but rather a critical...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2014.12.008
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Aging is an important contributor to olfactory system deterioration in humans, leading to increased health and safety risks as well as affecting the quality of life. However, it is currently unknown when age-related olfactory deterioration begins in humans and thus when to initiate interventions to prevent o...
journal_title：Ageing research reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.arr.2017.08.004
更新日期：2017-11-01 00:00:00
abstract：:Coronary artery disease is the leading cause of death in industrialized countries for people older than 65 years of age. The reasons are still unclear. A reduction of endogenous mechanisms against ischemic insults has been proposed to explain this phenomenon. Cardiac ischemic preconditioning represents the most powerf...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.07.001
更新日期：2010-04-01 00:00:00
abstract：INTRODUCTION:Many transplant studies in elderly patients focus on survival and mortality rates. It was the aim of this review to evaluate publications dealing with individual patient performance and independence. METHODS:The literature search included all articles retrievable for the hit "transplantation in elderly re...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2011.06.003
更新日期：2012-01-01 00:00:00
abstract：:Fibrosis is universally observed in multiple aging-related diseases and progressions and is characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various human organs and eventually results in organ failure. Noncoding RNAs (ncRNAs) have emerged as essential regulators of cellular signali...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.04.001
更新日期：2019-07-01 00:00:00
abstract：:The use of non-human primate models is required to understand the ageing process and evaluate new therapies against age-associated pathologies. The present article summarizes all the contributions of the grey mouse lemur Microcebus murinus, a small nocturnal prosimian primate, to the understanding of the mechanisms of...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2011.07.001
更新日期：2012-01-01 00:00:00
abstract：:The aging of the human adrenal cortex presents several problems of interest to the cell biologist, as the interplay of changes in growth, differentiation, apoptosis and cellular senescence affect the properties of the tissue over the life span. The human adrenal cortex also presents an interesting case of tumor progre...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/s1568-1637(01)00007-1
更新日期：2002-04-01 00:00:00
abstract：:Persons aged 80 years and older are the fastest growing segment of the population. As more individuals live longer, we should try to understand the mechanisms involved in healthy ageing and preserving functional independence in later life. In elderly people, functional independence is directly dependent on physical fi...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2012.09.003
更新日期：2013-01-01 00:00:00
abstract：:Within the last years, a rapidly growing number of polyphenolic compounds with neuroprotective effects have been described. Many efforts have been made to explore the mechanisms behind the neuroprotective action of polyphenols. However, many pathways and mechanisms considered for mediating these effects are rather gen...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2012.01.006
更新日期：2012-04-01 00:00:00
abstract：:Emerging data show that the health and economic impacts of COVID-19 are being disproportionately borne by individuals who are not only biologically, but also socially vulnerable. Based on preliminary data from Sweden and other reports, in this paper we propose a conceptual framework whereby different factors related t...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101149
更新日期：2020-11-01 00:00:00
abstract：:A wide array of cell signaling mediators and their interactions play vital roles in neuroinflammation associated with ischemia, brain trauma, developmental disorders and age-related neurodegeneration. Along with neurons, microglia and astrocytes are also affected by the inflammatory cascade by releasing pro-inflammato...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.02.004
更新日期：2017-07-01 00:00:00
abstract：:As human life expectancy rises, the aged population will increase. Aging is accompanied by changes in tissue structure, often resulting in functional decline. For example, aging within blood vessels contributes to a decrease in blood flow to important organs, potentially leading to organ atrophy and loss of function. ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.09.007
更新日期：2017-03-01 00:00:00
abstract：:Uncoupling proteins (UCPs), which dissipate the mitochondrial proton gradient, have the ability to decouple mitochodrial respiration from ATP production. Since mitochondrial electron transport is a major source of free radical production, it is possible that UCP activity might impact free radical production. Free radi...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2006.03.007
更新日期：2006-05-01 00:00:00
abstract：:The amyloid cascade hypothesis, which implicates the amyloid Aβ peptide as the pathological initiator of both familial and sporadic, late onset Alzheimer's disease (AD), continues to guide the majority of research. We believe that current evidence does not support the amyloid cascade hypothesis for late onset AD. Inst...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2013.10.001
更新日期：2014-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder involving deposition of misfolded proteins in vulnerable brain regions leading to inexorable and progressive neuronal loss and deterioration of cognitive functions. The AD brain displays features typical of chronic inflammation as defined by the presence of acti...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2011.12.004
更新日期：2012-04-01 00:00:00
abstract：:Aging is associated with a general decline in physiological functions including cognitive functions. Given that the hippocampus is known to be critical for certain forms of learning and memory, it is not surprising that a number of neuronal processes in this brain area appear to be particularly vulnerable to the aging...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2004.05.002
更新日期：2004-11-01 00:00:00
abstract：:Elder abuse has devastating consequences for older persons such as a poor quality of life, psychological distress, and loss of property and security. It is also associated with increased mortality and morbidity. Elder abuse is a problem that manifests itself in both rich and poor countries and at all levels of society...
journal_title：Ageing research reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.arr.2012.04.001
更新日期：2013-01-01 00:00:00
abstract：:As we age, our skeletal muscle becomes smaller and weaker. In addition, the remaining muscle is more susceptible to damage, particularly following exercise, recovery from damage is severely impaired and muscle is unable to adapt rapidly following sequential periods of exercise. The mechanisms by which skeletal muscle ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/s0047-6374(01)00368-2
更新日期：2002-02-01 00:00:00
abstract：:The global population is aging, leading to an increasing burden of age-related neurodegenerative disease. Efforts to intervene against age-related dementias in older adults have generally proven ineffective. These failures suggest that a lifetime of brain aging may be difficult to reverse once widespread deterioration...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101075
更新日期：2020-08-01 00:00:00
abstract：:Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are only partly understood. Therefore, studying the basic mechanisms underlying structural and functional recovery after brain injury in aged subjects is of conside...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.10.008
更新日期：2011-01-01 00:00:00
abstract：:A literature search was carried out to review the influence of 'ageing' on pharmacotherapeutic decision-making, specifically how 'age' is defined and considered in the utilisation of medication. Embase, Medline, International Pharmaceutical Abstracts, and Google scholar were canvassed in a three-tiered search accordin...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2015.07.006
更新日期：2015-11-01 00:00:00
