Abstract:
:Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of ageing appear, causing disease formation. Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economical burdens. In seeking to ameliorate ageing and age-related diseases, the search for anti-ageing drugs has been of much interest. Numerous studies have shown that the plant polyphenol, resveratrol (3,5,4'-trihydroxystilbene), extends the lifespan of several species, prevents age-related diseases, and possesses anti-inflammatory, and anti-cancer properties. The beneficial effects of resveratrol are believed to be associated with the activation of a longevity gene, SirT1. In this review, we discuss the pathogenesis of age-related neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and cerebrovascular disease. The therapeutic potential of resveratrol, diet and the roles of stem cell therapy are discussed to provide a better understanding of the ageing mystery.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Hung CW,Chen YC,Hsieh WL,Chiou SH,Kao CLdoi
10.1016/j.arr.2010.08.006subject
Has Abstractpub_date
2010-11-01 00:00:00pages
S36-46eissn
1568-1637issn
1872-9649pii
S1568-1637(10)00063-2journal_volume
9 Suppl 1pub_type
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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doi:10.1016/j.arr.2020.101149
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2014.02.004
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2016.06.006
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101114
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2014.09.002
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2016.09.007
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journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2011.11.002
更新日期:2012-01-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.04.001
更新日期:2018-07-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2004.01.003
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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