Abstract：
:Aging impairs blood vessel function and leads to cardiovascular disease. The mechanisms underlying the age-related endothelial, smooth muscle and extracellular matrix vascular dysfunction are discussed. Vascular dysfunction is caused by: (1) Oxidative stress enhancement. (2) Reduction of nitric oxide (NO) bioavailability, by diminished NO synthesis and/or augmented NO scavenging. (3) Production of vasoconstrictor/vasodilator factor imbalances. (4) Low-grade pro-inflammatory environment. (5) Impaired angiogenesis. (6) Endothelial cell senescence. The aging process in vascular smooth muscle is characterized by: (1) Altered replicating potential. (2) Change in cellular phenotype. (3) Changes in responsiveness to contracting and relaxing mediators. (4) Changes in intracellular signaling functions. Systemic arterial hypertension is an age-dependent disorder, and almost half of the elderly human population is hypertensive. The influence of hypertension on the aging cardiovascular system has been studied in models of hypertensive rats. Treatment for hypertension is recommended in the elderly. Lifestyle modifications, natural compounds and hormone therapies are useful for initial stages and as supporting treatment with medication but evidence from clinical trials in this population is needed. Since all antihypertensive agents can lower blood pressure in the elderly, therapy should be based on its potential side effects and drug interactions.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Rubio-Ruiz ME,Pérez-Torres I,Soto ME,Pastelín G,Guarner-Lans Vdoi
10.1016/j.arr.2014.10.001subject
Has Abstractpub_date
2014-11-01 00:00:00pages
132-47eissn
1568-1637issn
1872-9649pii
S1568-1637(14)00110-Xjournal_volume
18pub_type
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journal_title：Ageing research reviews
pub_type： 杂志文章,meta分析,评审
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journal_title：Ageing research reviews
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journal_title：Ageing research reviews
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pub_type： 杂志文章,评审
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journal_title：Ageing research reviews
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
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journal_title：Ageing research reviews
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journal_title：Ageing research reviews
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journal_title：Ageing research reviews
pub_type： 杂志文章,meta分析
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
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journal_title：Ageing research reviews
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journal_title：Ageing research reviews
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
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journal_title：Ageing research reviews
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,meta分析,评审
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
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journal_title：Ageing research reviews
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
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journal_title：Ageing research reviews
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