Abstract:
:Chronic renal failure (CRF) is almost always associated with high arterial blood pressure. Adequate control of hypertension slows down the progression of the disease, Inhibitors of angiotenzin-converting enzyme (ACE inhibitors) have proved to be very efficacious in decreasing high blood pressure. The aim of this study was to assess the influence of ACE inhibitor enalapril on the progression of CRF in patients with diabetic nephropathy and nephropathies of other origin. During 1998 and 1999 thirty patients (20 males and 10 females, aged 525 +/- 1.3) have been followed-up at the Department of Nephrology, Clinical Centre of Serbia. On regular monthly controls serum creatinine, urea, calcium and protein levels, creatinine clearance, and blood pressure, were measured. All patients were suggested a low protein diet. Progression of the disease was expressed by the slope of the regression line showing reciprocal serum creatinine values. Proteinaemia was significantly higher in diabetic patients after 12 months (p < 0.35), but in the next 12 months the difference between groups disappeared. The same patients had significantly lower serum urea (p < 0.05) after 24 months and creatinine values (p < 0.05) during the whole study. Other variables changed in the same manner and with similar progression in both groups. The direction of slope lines suggested recovery of kidney function in both examined groups. However, a smaller slope in patients with diabetic nephropathy together with other results showed that enalapril had better influence on slowing down the progression of CRF in this group of patients.
journal_name
Srp Arh Celok Lekjournal_title
Srpski arhiv za celokupno lekarstvoauthors
Trbojević J,Stojimirović Bdoi
10.2298/sarh0204087tkeywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
87-90issue
3-4eissn
0370-8179issn
2406-0895journal_volume
130pub_type
杂志文章abstract::The study concerned pathogenetic mechanisms of occurrence of tuberculous meningitis and modern recommendations for therapy. Meningitis has never been a primary localization of tuberculous infection, but the latter appears by dissemination from some primary, extrameningeal focus which is frequently clinically unapparen...
journal_title:Srpski arhiv za celokupno lekarstvo
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更新日期:1996-01-01 00:00:00
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journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 杂志文章
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 杂志文章
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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journal_title:Srpski arhiv za celokupno lekarstvo
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