[Chronic rhinitis--effect of topical administration of corticosteroids on eosinophilic leukocytes].

Abstract:

:Clinical manifestation of chronic rhinitis is due to local release of mediators from inflammatory cells. Eosinophil leukocytes are important in pathogenesis of nasal hypersensitivity as well as nasal hyperreactivity [1, 2]. The aim of the study was to follow-up the effect of local corticosteroid treatment on a number of eosinophils in nasal secretion of patients with chronic rhinitis. The study was prospective and controlled. A total number of 88 subjects was included in the study. Patients with chronic rhinitis who were treated with local corticosteroids (63) constituted the experimental group (37 with isolated allergic rhinitis, 10 with isolated nonallergic noninfective hyperreactive rhinitis, 10 with allergic rhinitis associated with nasal polyposis and 6 with nonallergic noninfective hyperreactive rhinitis associated with nasal polyposis). There were 25 patients with chronic rhinitis in the control group (18 with isolated allergic rhinitis, 2 with isolated nonallergic noninfective hyperreactive rhinitis, 3 with allergic rhinitis associated with nasal polyposis, and 2 with nonallergic noninfective, hyperreactive rhinitis associated with nasal polyposis). During the treatment with beclomethasone dipropionate aqueous nasal spray (daily dose was 400 micrograms during 6 weeks for isolated rhinitis and 6 months for associated forms of rhinitis), control examinations were regulary performed. The first control was after one week, the second after six weeks, the third after three months and the fourth after six months. The same control was carried out in the control group of patients who were without therapy. Cytological examination of nasal secretions included brush method of collecting secretions, staining smears with Leishman's stain and light microscopic scrutinising of nasal smear magnified up to 1000 times. The results of the study demonstrated the highly significant decrease in the number of eosinophils after the therapy in patients with isolated allergic rhinitis (x2(FR) = 71,121, DF = 2, p < 0.01), in patients with isolated hyperreactive rhinitis (x2(FR) = 19,050, DF = 2, p < 0.01), in patients with allergic rhinitis associated with nasal polyposis (x2(FR) = 26,730, DF = 3, p < 0.01), as well as in patients with hyperreactive rhinitis associated with nasal polyposis (x2(FR) = 17,000, DF = 3, p < 0.01). There were no significant differences in control group of patients, neither in subgroup with allergic rhinitis (x2(FR) = 2,528, DF = 2, p > 0.05) nor in subgroup with hyperreactive rhinitis associated with nasal polyposis (x2(FR) = 0.250, DF = 2, p > 0.05) (Table 2). Local corticosteroids have the potential to influence the regulation of eosinophil apoptosis. The induction of apoptosis by beclomethasone dipropionate treatment is an efficient way to remove eosinophil leukocytes from inflammatory sites [8]. The locally used corticosteroids in chronic rhinitis reduced significantly the number of eosinophils in nasal secretion. This result proves immunomodulatory effects of these medicaments in the pathogenesis of chronic rhinitis.

journal_name

Srp Arh Celok Lek

authors

Ursulović D,Janosević L,Janosević S

doi

10.2298/sarh0208243u

keywords:

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

243-6

issue

7-8

eissn

0370-8179

issn

2406-0895

journal_volume

130

pub_type

临床试验,杂志文章
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    doi:10.2298/sarh04s1109g

    authors: Grković S,Jesić M,Jesić M,Maglajlić S

    更新日期:2004-10-01 00:00:00

  • [Current diagnosis of classic mastitis carcinomatosa].

    abstract::Mastitis carcinomatosa (inflammatory carcinoma) is a very rare form of breast cancer, with a rapid progress, generalisation and dissemination into the vital organs, and lethal issue. Inflammatory carcinoma of the breast (ICB) accounts for 1 to 4 per cent of all breast carcinomas. Only 3 to 6 per cent of patients survi...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:

    authors: Borojević N,Trbojević P,Zamurović J

    更新日期:1990-03-01 00:00:00

  • [Therapeutic use of glucocorticoids and immunosuppressive agents].

    abstract::Pharmacotherapy of autoimmune thyroid disease (AITD) is complex. Apart from the replacement hormone therapy, antithyroid agents, beta adrenoceptor blockers and other drugs, in regard to the present symptoms, it also includes the administration of glucocorticoids and immunosuppressive agents. Physiological actions of g...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:10.2298/sarh05s1067g

    authors: Grbović L,Radenković M

    更新日期:2005-10-01 00:00:00

  • [Problems with current hypertension definition in children].

    abstract::The Task Force data have added immeasurably to our understanding of the normal distribution of blood pressure in children. However, the manner in which arterial hypertension is defined in children is not without problems. The main problem is that the current definition of hypertension in children is not based on the e...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Peco-Antić A

    更新日期:2008-01-01 00:00:00

  • Heterotopic pregnancy after in vitro fertilization and embryo transfer: a case report.

    abstract:INTRODUCTION:Heterotopic pregnancy is a life-threatening complication of pregnancy defined as coexistent intrauterine and ectopic gestation. Its diagnosis is frequently overlooked and delayed. CASE OUTLINE:A 28-year-old woman experienced acute abdominal pain in pregnancy achieved by in vitro fertilization. Since all p...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Sparić R,Buzadzić S,Argirović R,Bratić D,Plećas D

    更新日期:2012-07-01 00:00:00

  • [Making a diagnosis of different lesions of vocal fold mucosa by contact endoscopy--the first usage in our clinical practice].

    abstract::During laryngomicroscopy, the superficial layers of vocal fold epithelium can be examined in vivo and in situ by contact endoscopy. Methylene blue is applied initially to stain the epihelial cells of the vocal folds. When in contact with mucosal tissue, this endoscope provides 60 and 150 times magnification and clear ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0504134j

    authors: Jovanović MB,Perović-Jovanović J,Milenkovć S

    更新日期:2005-03-01 00:00:00

  • [Effectiveness of peritoneal dialysis].

    abstract:INTRODUCTION:In the last few years, an increasing number of patients suffering from terminal renal disease of various leading causes was treated with renal replacement therapy. Peritonaeal dialysis involves an exchange of water and solutes between blood in the peritonaeal capillaries and dialysate in the peritonaeal ca...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0512498j

    authors: Jovanović N,Lausević M,Nesić V,Stojimirović B

    更新日期:2005-11-01 00:00:00

  • [Moderate ischemic mitral regurgitation: to operate or to ignore?].

    abstract:INTRODUCTION:Moderate ischemic mitral regurgitation (MR) is characterized by significant, symptomatic multivessel coronary disease and mitral regurgitation 2-3+. CASE OUTLINE:A 60-year-old patient was admitted at the Cardiovascular Institute "Dedinje" due to the symptoms of unstable angina pectoris. He survived a myoc...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0906275t

    authors: Tasić N,Otasević P,Bosković S,Popov P

    更新日期:2009-05-01 00:00:00

  • [Clinical significance of infection with cag A and vac A positive Helicobacter pylori strains].

    abstract::Clinical relevance of infection with different Helicobacter pylori strains was reviewed in this paper. Helicobacter pylori (H. pylori) infection plays a role in pathogenesis of chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. Extragastric manifestations of H. pylori infection most pro...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:10.2298/sarh0412458s

    authors: Sokić-Milutinović A,Todorović V,Milosavljević T

    更新日期:2004-11-01 00:00:00

  • [Stylocarotid syndrome: a case report].

    abstract:INTRODUCTION:The American otolaryngologist Eagle was the first to describe styloid syndrome in 1937 and the syndrome was named after him (Eagle's syndrome). The original description of two separate syndromes is connected with his name: classical syndrome, which almost constantly occurs after tonsillectomy and carotid a...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0812650p

    authors: Petrović B,Radak D,Kostić V,Covicković-Sternić N

    更新日期:2008-11-01 00:00:00

  • [Subclinical disorders of left ventricular function in diabetics detected by echocardiography].

    abstract::In diabetic patients, without coronary heart disease and hypertension, left ventricular filing dysfunction exist, that is registered by echocardiography. It is manifested as greater peak flow velocity during atrial systole and as shorter time from the aortic second heart sound to the peak of the early diastolic flow v...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Visekruna T,Mijalković D,Djurić B,Pudar-Branković G

    更新日期:1992-07-01 00:00:00

  • [Pseudoarthrosis of the scaphoid bone associated with carpal collapse: factors in choice of surgical approach].

    abstract:INTRODUCTION:The most common fracture involving the wrist is a fracture of the scaphoid bone [1], and only 5% to 10% of these fractures proceed to nonunion. Although not symptomatic initially, most (if not all) nonunions later produce a painful wrist with impaired function, clinically significant loss of motion, increa...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Miric D,Senohradski K,Vucetic C,Djordjevic Z

    更新日期:2001-05-01 00:00:00

  • [Peritoneal dialysis in the treatment of acute renal insufficiency].

    abstract::106 patients with acute renal failure (ARF) treated with peritoneal dialysis (PD) for the last 15 years (except for postrenal ARF treated only with HD, or ARF with conservative treatment) were analyzed. The commonest causes were sepsis (3), hemorrhagic fever (17) and complications of some internal or surgical disease ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Iknomovski J,Majster Z

    更新日期:1996-01-01 00:00:00

  • Temperature variation on root surface with three root-end cavity preparation techniques.

    abstract:INTRODUCTION:Thermal changes can occur on the external root surface when root-end cavity preparation is performed, which may damage periodontal ligament cells and alveolar bone. OBJECTIVE:The purpose of this study was to evaluate the temperature changes during preparation of the root-end cavities at 1 and 3 mm to the ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1310597b

    authors: Bodrumlu E,Keskiner I,Sumer M,Telcioglu NT

    更新日期:2013-09-01 00:00:00

  • [Inhibition of angiogenesis in the cornea with amiloride].

    abstract:INTRODUCTION:For its transparency, avascularity and possibility of measurement of the new vessels ingrowth, cornea is a frequent model for angiogenesis research. New vessels are made in several phases: after the action of the stimulus, there is a localised fragmentation of the basal membrane and the extracellular matri...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Ignjatović Z,Nikolić Lj

    更新日期:1996-05-01 00:00:00

  • Implementation of multiple intelligences theory in the English language course syllabus at the University of Nis Medical School.

    abstract:INTRODUCTION:Theory of multiple intelligences (MI) is considered an innovation in learning the English language because it helps students develop all eight intelligences that, on the other hand, represent ways people understand the world around them, solve problems and learn. They are: verbal/linguistic, logical/mathem...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Bakić-Mirić N

    更新日期:2010-01-01 00:00:00

  • [The value of neuroendocrine markers for response to therapy and survival in patients with advanced non-small cell lung cancer].

    abstract:INTRODUCTION:Non-small cell lung cancer (NSCLC) accounts for about 70-80% of all lung cancers. In comparison with small cell lung cancer, NSCLC has relatively low therapy response. Discovery of neuroendocrine markers within the NSCLC group (10-30%) has initiated the issue of their importance in the therapy and prognosi...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1002037p

    authors: Petrović M,Ilić N,Baskić D

    更新日期:2010-01-01 00:00:00

  • Development and evaluation of the nurse quality of communication with patient questionnaire.

    abstract:INTRODUCTION:Nurse/patient relationship as a complex interrelation or as an interaction of the factor patient and factor nurse has been a subject of a number of studies during the past ten years. Nurse/patient communication is a special entity, usually observed within a framework of the wider nurse/patient relationship...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1002079v

    authors: Vuković M,Gvozdenović BS,Stamatović-Gajić B,Ilić M,Gajić T

    更新日期:2010-01-01 00:00:00

  • [Cytology in the diagnosis of diseases of the nose and maxilary sinuses].

    abstract::The aim of this work is to evaluate cytologic examination of secretions of nose and maxillary sinuses in patients with naso-sinusal disorders. The material for cytologic examination is taken from 128 nasal cavities of 101 patients with inflammation or tumour diseases of nose and maxillary sinuses, and from 114 maxilla...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Belić B,Andrić V,Tadić L,Vasković Z,Stojanović S,Krsmanović J

    更新日期:2002-05-01 00:00:00

  • [Drug facilitated sexual assault].

    abstract::In line with the fact that there is little information regarding drug facilitated sexual assault in national medical literature, the authors aimed to prepare a review of the phenomenon based on available international references. Therefore we offered a definition of the concept of sexual assault, and rape in particula...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:

    authors: Alempijević D,Savić S,Stojanović J,Spasić A

    更新日期:2007-03-01 00:00:00

  • [Infected tibial nonunions--treatment by the Ilizarov method: multicentric study].

    abstract:INTRODUCTION:Associated bone tissue defect and infection, commonly result in non-healing, i.e., by the development of infected tibial nonunion. OBJECTIVE:The aim of the paper was to present experiences acquired in the treatment of this problem by the application of the Ilizarov method. METHODS:The analyses enrolled 1...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,多中心研究

    doi:10.2298/sarh1202065v

    authors: Vukašinović Z,Spasovski D,Vučetić Č,Jovanović V,Šešlija I,Živković Z

    更新日期:2012-01-01 00:00:00

  • [Jeune's syndrome (3 case reports)].

    abstract::Jeune's syndrome or asphyxiating thoracic dystrophy is an autosomal recessive osteochondrodysplasia with multisystem involvement. In patients who survive neonatal period in the main clinical feature progressive renal failure is. Renal lesions are variable but is familial juvenile nephronophtisis the most frequent one....

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Novaković I,Kostić M,Popović-Rolović M,Sindjić M,Peco-Antić A,Jovanović O,Krscić D

    更新日期:1996-01-01 00:00:00

  • [Clinical evaluation of Graves ophthalmopathy].

    abstract:INTRODUCTION:Graves ophthalmopathy is an autoimmune disease, which is the consequence of thyroid dysfunction. Ocular manifestations occur in 50% of patients with Graves disease. The changes occur due to the inflammatory cell infiltration of retrobulbar fat tissue and extraocular muscles. Ultrasonography of eye orbit pr...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1212694j

    authors: Janićijević-Petrović MA,Šarenac T,Srećković S,Janićijević K,Petrović M,Vulović D

    更新日期:2012-11-01 00:00:00

  • [Serum antithyroid antibodies in patients with pernicious anemia].

    abstract::We investigated the incidence of thyroid auto-antibodies and their relationship to antigastric antibodies in 20 euthyroid patients with pernicious anaemia. To evaluate possible thyroid dysfunction we also measured total level of thyroid hormones (TT3 and TT4) and TSH in our patients. Histologic evidence of autoimmune ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Kostić N,Jelić S,Han R,Ristić S,Bozanić M

    更新日期:1990-07-01 00:00:00

  • [Gingival and dental parameters in the evaluation of aesthetic characteristics of fixed restoratons (II)].

    abstract::This paper is a continuing evaluation of dental and facial parameters in the estimation of aesthetic characteristic of fixed restorations. First of all, attention is paid to the phenomenon describing the tooth tissue's characteristics (translucency, opalescence, and transparency). The paper also discusses tooth colour...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:10.2298/sarh0506288o

    authors: Obradović-Duricić K

    更新日期:2005-05-01 00:00:00

  • [Multiple endometrial polyps in patient undergoing long-term gestagen therapy].

    abstract::Endometrial polyps represent a limited focal, circumscribed overgrowth of the endometrium. Their aetiopathogenesis has not been completely explained yet. They are often found in perimenopausal women; during the reproductive period they are less common. We present the case of a 32-year-old patient, who came for a check...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0510438z

    authors: Zamurović M,Srbinović P,Petrović J

    更新日期:2005-09-01 00:00:00

  • Neurosensory outcome of prematurely born children following intracranial haemorrhage.

    abstract:INTRODUCTION:More and more survival of newborns with small or extremely small body mass at birth, as well as increasing percent of prematurely born babies, have emphasized the significance of intracranial haemorrhage problem. Prematurely born infants are under increased risk for strabismus, amblyopia, blinding and hear...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1102006v

    authors: Velisavljev-Filipović G

    更新日期:2011-01-01 00:00:00

  • [Therapeutic aspects of trichomoniasis].

    abstract:INTRODUCTION:Trichomoniasis is frequent, parasitic and sexually transmitted infection of genitourinary tract. It is treated by metronidazole (5-nitroimidazole), according to protocol recommended by Center for Disease Control (CDC, formerly called: Communicable Disease Center) [19]. The resistance of Trichomonas vaginal...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0304156v

    authors: Vukićević J,Jankicević J

    更新日期:2003-03-01 00:00:00

  • Boceprevir in genotype 1 chronic hepatitis C: first experiences in Serbia.

    abstract:INTRODUCTION:The triple therapy which consists of one of the protease inhibitor plus pegylated interferon and ribavirin (P/R) is the standard of care for the treatment of chronic hepatitis C virus (HCV) genotype 1 (G1) infection both in treatment-naïve and experienced patients. OBJECTIVE:The aim of this study was to a...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Babić JS,Bojović K,Fabri M,Kostić V,Jovanović M,Mijailović Z,Svorcan P,Janković G

    更新日期:2015-01-01 00:00:00

  • [Reduced glutathione level and GSH-dependent enzyme activities in corticonuclear blocks of lenses in patients with senile cataract].

    abstract:INTRODUCTION:Reduced compound glutathione (GSH) in the lens has the function to protect the thiol group of lens proteins, and as a substrate of glutathione peroxidase (GPx) and glutathione S-transferase (GST). Protein containing thiol groups is significant for the normal function of lens epithelium, i.e. enzymes Na-K-A...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1210563k

    authors: Kisić B,Mirić D,Žorić L,Ilić A,Dragojević I

    更新日期:2012-09-01 00:00:00