Effectiveness of intracanal irrigants and medications against the yeast Candida albicans.

Abstract:

:An in vitro study was conducted to determine the susceptibility of the yeast Candida albicans to various intracanal irrigants and medications. The minimum inhibitory concentration (MIC) of sodium hypochlorite, hydrogen peroxide, chlorhexidine digluconate, and aqueous calcium hydroxide that is required to kill a standardized inoculum of C. albicans was determined. Growth of the yeast was measured by optical density. Sodium hypochlorite, hydrogen peroxide, and chlorhexidine digluconate were effective anticandidal agents with MICs of <10 microgram/ml, 234 microgram/ml, and <0.63 microgram/ml, respectively. Aqueous calcium hydroxide had no activity. A standardized inoculum of C. albicans cells was also placed in direct contact with either calcium hydroxide paste or camphorated para-monochlorophenol (CPMC), and candidal growth was assessed by colony counts on Sabouraud's dextrose agar. Calcium hydroxide paste and CPMC, when maintained in direct contact with C. albicans, were effective antifungal agents.

journal_name

J Endod

journal_title

Journal of endodontics

authors

Ferguson JW,Hatton JF,Gillespie MJ

doi

10.1097/00004770-200202000-00004

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

68-71

issue

2

eissn

0099-2399

issn

1878-3554

pii

S0099-2399(05)60583-3

journal_volume

28

pub_type

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