The concentration of prostaglandin E2 in human periradicular lesions.

Abstract:

:Prostaglandins (PG) have been implicated in the genesis of periapical lesions. Periapical specimens from patients with clinical signs and symptoms of chronic and acute apical periodontitis were obtained and immediately frozen in liquid nitrogen. Periradicular tissues from unerupted third molars were frozen and used as controls. The concentration of PGE2 was determined by radioimmunoassay. Low levels of PGE2 were found in the control tissues as compared with those detected in chronic and acute lesions. Significantly higher levels of PGE2 were found in acute lesions than those found in chronic lesions. The results show that acute lesions have higher concentrations of PGE2 than chronic lesions and confirm the role of prostaglandins in the pathogenesis of human periapical lesions.

journal_name

J Endod

journal_title

Journal of endodontics

authors

McNicholas S,Torabinejad M,Blankenship J,Bakland L

doi

10.1016/S0099-2399(06)81737-1

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

97-100

issue

3

eissn

0099-2399

issn

1878-3554

pii

S0099-2399(06)81737-1

journal_volume

17

pub_type

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