Abstract:
:The 5'- and 3'-untranslated regions (5'- and 3'-UTRs) of eukaryotic mRNAs are known to play a crucial role in post-transcriptional regulation of gene expression modulating nucleo-cytoplasmic mRNA transport, translation efficiency, subcellular localization and stability. UTRdb is a specialized database of 5' and 3' untranslated sequences of eukaryotic mRNAs cleaned from redundancy. UTRdb entries are enriched with specialized information not present in the primary databases including the presence of nucleotide sequence patterns already demonstrated by experimental analysis to have some functional role. All these patterns have been collected in the UTRsite database so that it is possible to search any input sequence for the presence of annotated functional motifs. Furthermore, UTRdb entries have been annotated for the presence of repetitive elements. All Internet resources we implemented for retrieval and functional analysis of 5'- and 3'-UTRs of eukaryotic mRNAs are accessible at http://bighost.area.ba.cnr.it/BIG/UTRHome/.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Pesole G,Liuni S,Grillo G,Licciulli F,Mignone F,Gissi C,Saccone Cdoi
10.1093/nar/30.1.335keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
335-40issue
1eissn
0305-1048issn
1362-4962journal_volume
30pub_type
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