Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis.

abstract：:Protein functions require conformational motions. We show here that the dominant conformational motions are slaved by the hydration shell and the bulk solvent. The protein contributes the structure necessary for function. We formulate a model that is based on experiments, insights from the physics of glass-forming liq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frauenfelder H,Chen G,Berendzen J,Fenimore PW,Jansson H,McMahon BH,Stroe IR,Swenson J,Young RD

更新日期：2009-03-31 00:00:00

abstract：:We study the physical origins of phase contrast in dynamic atomic force microscopy (dAFM) in liquids where low-stiffness microcantilever probes are often used for nanoscale imaging of soft biological samples with gentle forces. Under these conditions, we show that the phase contrast derives primarily from a unique ene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melcher J,Carrasco C,Xu X,Carrascosa JL,Gómez-Herrero J,José de Pablo P,Raman A

更新日期：2009-08-18 00:00:00

abstract：:Mechanical forces have key roles in regulating activation of T cells and coordination of the adaptive immune response. A recent example is the ability of T cells to sense the rigidity of an underlying substrate through the T-cell receptor (TCR) coreceptor CD3 and CD28, a costimulation signal essential for cell activat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bashour KT,Gondarenko A,Chen H,Shen K,Liu X,Huse M,Hone JC,Kam LC

更新日期：2014-02-11 00:00:00

abstract：:Some dinosaurs reached masses that were approximately 8 times those of the largest, ecologically equivalent terrestrial mammals. The factors most responsible for setting the maximal body size of vertebrates are resource quality and quantity, as modified by the mobility of the consumer, and the vertebrate's rate of ene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McNab BK

更新日期：2009-07-21 00:00:00

abstract：:Aneuploidy, a chromosome content other than a multiple of the haploid number, is a common feature of cancer cells. Whole chromosomal aneuploidy accompanying ongoing chromosomal instability in mice resulting from reduced levels of the centromere-linked motor protein CENP-E has been reported to increase the incidence of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silk AD,Zasadil LM,Holland AJ,Vitre B,Cleveland DW,Weaver BA

更新日期：2013-10-29 00:00:00

abstract：:The HIV type 1 (HIV-1) virion infectivity factor (Vif) protein blocks the action of the host defense factor APOBEC3G in human cells, thereby allowing release of infectious virions, but fails to inhibit similar APOBEC3G proteins present in some simian cells. Conversely, the Vif protein encoded by the African green monk...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bogerd HP,Doehle BP,Wiegand HL,Cullen BR

更新日期：2004-03-16 00:00:00

abstract：:The yeast SIN1 protein is a nuclear protein that together with other proteins behaves as a transcriptional repressor of a family of genes. In addition, sin1 mutants are defective in proper mitotic chromosome segregation. In an effort to understand the basis for these phenotypes, we employed the yeast two-hybrid system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shpungin S,Liberzon A,Bangio H,Yona E,Katcoff DJ

更新日期：1996-08-06 00:00:00

abstract：:Reverse transcriptase (RNA-directed DNA polymerase, EC 2.7.7.49) of human immunodeficiency virus type 1 has been examined with respect to the steady-state kinetics of polymerization of dNTPs into product DNA. With dNTPs as variable substrate, the kinetics of polymerization deviated from standard Michaelis-Menten kinet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： West AB,Roberts TM,Kolodner RD

更新日期：1992-10-15 00:00:00

abstract：:The biological function of Glu-181 in the photoactivation process of rhodopsin is explored through spectroscopic studies of site-specific mutants. Preresonance Raman vibrational spectra of the unphotolyzed E181Q mutant are nearly identical to spectra of the native pigment, supporting the view that Glu-181 is uncharged...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan EC,Kazmi MA,Ganim Z,Hou JM,Pan D,Chang BS,Sakmar TP,Mathies RA

更新日期：2003-08-05 00:00:00

abstract：:Microtubules (MTs) are hollow cytoskeletal filaments assembled from αβ-tubulin heterodimers. Tau, an unstructured protein found in neuronal axons, binds to MTs and regulates their dynamics. Aberrant Tau behavior is associated with neurodegenerative dementias, including Alzheimer's. Here, we report on a direct force me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung PJ,Choi MC,Miller HP,Feinstein HE,Raviv U,Li Y,Wilson L,Feinstein SC,Safinya CR

更新日期：2015-11-24 00:00:00

abstract：:An immature state of cellular differentiation--characterized by stem cell-like tendencies and impaired differentiation--is a hallmark of cancer. Using glioblastoma multiforme (GBM) as a model system, we sought to determine whether molecular determinants that drive cells toward terminal differentiation are also genetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu J,Ho AL,Yuan L,Hu B,Hua S,Hwang SS,Zhang J,Hu T,Zheng H,Gan B,Wu G,Wang YA,Chin L,DePinho RA

更新日期：2013-09-03 00:00:00

abstract：:There is a high mortality in patients with diabetes and severe pressure ulcers. For example, chronic pressure sores of the heels often lead to limb loss in diabetic patients. A major factor underlying this is reduced neovascularization caused by impaired activity of the transcription factor hypoxia inducible factor-1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duscher D,Neofytou E,Wong VW,Maan ZN,Rennert RC,Inayathullah M,Januszyk M,Rodrigues M,Malkovskiy AV,Whitmore AJ,Walmsley GG,Galvez MG,Whittam AJ,Brownlee M,Rajadas J,Gurtner GC

更新日期：2015-01-06 00:00:00

abstract：:Retinal prosthetics offer hope for patients with retinal degenerative diseases. There are 20-25 million people worldwide who are blind or facing blindness due to these diseases, and they have few treatment options. Drug therapies are able to help a small fraction of the population, but for the vast majority, their bes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nirenberg S,Pandarinath C

更新日期：2012-09-11 00:00:00

abstract：:The induction of heat shock proteins (HSP) by cellular stress and the activation of the hypothalamic-pituitary-adrenal axis by physiologic stress are biological responses that aid in the maintenance of cellular and organismal homeostasis, respectively. In this report, restraint stress, known to activate the hypothalam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blake MJ,Udelsman R,Feulner GJ,Norton DD,Holbrook NJ

更新日期：1991-11-01 00:00:00

abstract：:Artemis gene mutations are responsible for the development of a severe combined immunodeficiency [radiation-sensitive (RS) SCID] characterized by a severe B and T cell deficiency and a normal natural killer cell population. To establish the feasibility of a gene therapy approach to the treatment of RS-SCID, we generat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mostoslavsky G,Fabian AJ,Rooney S,Alt FW,Mulligan RC

更新日期：2006-10-31 00:00:00

abstract：:Neurons vary in their capacity to produce, store, and release neuropeptides packaged in dense-core vesicles (DCVs). Specifically, neurons used for cotransmission have terminals that contain few DCVs and many small synaptic vesicles, whereas neuroendocrine neuron terminals contain many DCVs. Although the mechanistic ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulgari D,Zhou C,Hewes RS,Deitcher DL,Levitan ES

更新日期：2014-03-04 00:00:00

abstract：:We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription factors. We present ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mink S,Mutschler B,Weiskirchen R,Bister K,Klempnauer KH

更新日期：1996-06-25 00:00:00

abstract：:The protein CopC from Pseudomonas syringae has been found capable of binding copper(I) and copper(II) at two different sites, occupied either one at a time or simultaneously. The protein, consisting of 102 amino acids, is known to bind copper(II) in a position that is now found consistent with a coordination arrangeme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnesano F,Banci L,Bertini I,Mangani S,Thompsett AR

更新日期：2003-04-01 00:00:00

abstract：:Familial adenomatous polyposis (FAP) is an autosomal-dominant disease characterized by the development of hundreds of adenomatous polyps of the colorectum. Approximately 80% of FAP patients can be shown to have truncating mutations of the APC gene. To determine the cause of FAP in the other 20% of patients, MAMA (mono...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laken SJ,Papadopoulos N,Petersen GM,Gruber SB,Hamilton SR,Giardiello FM,Brensinger JD,Vogelstein B,Kinzler KW

更新日期：1999-03-02 00:00:00

abstract：:Aggression is a universal social behavior important for the acquisition of food, mates, territory, and social status. Aggression in Drosophila is context-dependent and can thus be expected to involve inputs from multiple sensory modalities. Here, we use mechanical disruption and genetic approaches in Drosophila melano...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Versteven M,Vanden Broeck L,Geurten B,Zwarts L,Decraecker L,Beelen M,Göpfert MC,Heinrich R,Callaerts P

更新日期：2017-02-21 00:00:00

abstract：:Murine Ly-6-encoded molecules play an important role in the antigen-independent activation of lymphocytes. We have described the cloning of a cDNA encoding the protein component of an Ly-6 molecule. Hybridization studies indicated that this cDNA identified multiple DNA fragments on Southern blots. The banding pattern ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LeClair KP,Rabin M,Nesbitt MN,Pravtcheva D,Ruddle FH,Palfree RG,Bothwell A

更新日期：1987-03-01 00:00:00

abstract：:The sources of human germline mutations are poorly understood. Part of the difficulty is that mutations occur very rarely, and so direct pedigree-based approaches remain limited in the numbers that they can examine. To address this problem, we consider the spectrum of low-frequency variants in a dataset (Genome Aggreg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agarwal I,Przeworski M

更新日期：2019-09-03 00:00:00

abstract：:The role of GATA4 during the earliest stages of cardiogenesis has not been defined because Gata4 knockout embryos suffer an early developmental arrest caused by deficiencies in extraembryonic visceral endoderm function. We have used tetraploid embryo complementation to rescue these defects and generated clonal embryon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watt AJ,Battle MA,Li J,Duncan SA

更新日期：2004-08-24 00:00:00

abstract：:The usual way to compute Hartree-Fock type functions for molecules is by an expansion of the one-electron functions (molecular orbitals) in a linear combination of analytical functions (LCAO-MO-SCF, linear combination of atomic orbitals-Molecular Orbital-Self Consistent field). The expansion coefficients are obtained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clementi E

更新日期：1972-10-01 00:00:00

abstract：:Costimulation is required for optimal T cell activation, yet it is unclear whether poxviruses dedicatedly subvert costimulation during infection. Here, we report that the secreted M2 protein encoded by cowpox virus (CPXV) specifically interacts with human and murine B7.1 (CD80) and B7.2 (CD86). We also show that M2 co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Piersma SJ,Elliott JI,Errico JM,Gainey MD,Yang L,Nelson CA,Yokoyama WM,Fremont DH

更新日期：2019-10-15 00:00:00

abstract：:Serotonin (5-HT) controls a wide range of biological functions. In the brain, its implication as a neurotransmitter and in the control of behavioral traits has been largely documented. At the periphery, its modulatory role in physiological processes, such as the cardiovascular function, is still poorly understood. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Côté F,Thévenot E,Fligny C,Fromes Y,Darmon M,Ripoche MA,Bayard E,Hanoun N,Saurini F,Lechat P,Dandolo L,Hamon M,Mallet J,Vodjdani G

更新日期：2003-11-11 00:00:00

abstract：:In animals, fatty acid desaturases catalyze key reactions in the synthesis of arachidonic acid and other polyunsaturated fatty acids. A search of the Caenorhabditis elegans DNA databases, using the sequences of Arabidopsis genes, identified several putative desaturases. Here we describe the characterization of the fir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spychalla JP,Kinney AJ,Browse J

更新日期：1997-02-18 00:00:00

abstract：:Developing tissues contain motile populations of cells that can self-organize into spatially ordered tissues based on differences in their interfacial surface energies. However, it is unclear how self-organization by this mechanism remains robust when interfacial energies become heterogeneous in either time or space. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerchiari AE,Garbe JC,Jee NY,Todhunter ME,Broaders KE,Peehl DM,Desai TA,LaBarge MA,Thomson M,Gartner ZJ

更新日期：2015-02-17 00:00:00

abstract：:Six Rhesus monkeys between 24 and 29 years of age received unilateral transections of the fornix. Three monkeys then received intraventricular transplants of polymer-encapsulated baby hamster kidney (BHK) fibroblasts that had been genetically modified to secrete human nerve growth factor (hNGF). The remaining three mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kordower JH,Winn SR,Liu YT,Mufson EJ,Sladek JR Jr,Hammang JP,Baetge EE,Emerich DF

更新日期：1994-11-08 00:00:00

abstract：:We know a great deal about the cellular response to starvation via AMPK, but less is known about the reaction to nutrient excess. Insulin resistance may be an appropriate response to nutrient excess, but the cellular sensors that link these parameters remain poorly defined. In the present study we provide evidence tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoehn KL,Salmon AB,Hohnen-Behrens C,Turner N,Hoy AJ,Maghzal GJ,Stocker R,Van Remmen H,Kraegen EW,Cooney GJ,Richardson AR,James DE

更新日期：2009-10-20 00:00:00