Insulin resistance is a cellular antioxidant defense mechanism.

abstract：:An in vitro enzyme system for the conversion of amino acid to oxime in the biosynthesis of glucosinolates has been established by the combined use of an improved isolation medium and jasmonic acid-induced etiolated seedlings of Sinapis alba L. An 8-fold induction of de novo biosynthesis of the L-tyrosine-derived p-hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du L,Lykkesfeldt J,Olsen CE,Halkier BA

更新日期：1995-12-19 00:00:00

abstract：:The induction of heat shock proteins (HSP) by cellular stress and the activation of the hypothalamic-pituitary-adrenal axis by physiologic stress are biological responses that aid in the maintenance of cellular and organismal homeostasis, respectively. In this report, restraint stress, known to activate the hypothalam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blake MJ,Udelsman R,Feulner GJ,Norton DD,Holbrook NJ

更新日期：1991-11-01 00:00:00

abstract：:The carbohydrate binding specificity of leukoagglutinin (La; Phaseolus vulgaris isolectin L4) was studied by using quantitative precipitation and precipitation-inhibition. A series of purified glycopeptides and synthetic oligosaccharides were used as inhibitors. The minimal structural unit required for La binding was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammarström S,Hammarström ML,Sundblad G,Arnarp J,Lönngren J

更新日期：1982-03-01 00:00:00

abstract：:A key question in clarifying human-environment interactions is how dynamic complexity develops across integrative scales from molecular to population and global levels. Apart from its public health importance, measles is an excellent test bed for such an analysis. Simple mechanistic models have successfully illuminate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker AD,Birger RB,Teillant A,Gastanaduy PA,Wallace GS,Grenfell BT

更新日期：2016-12-20 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a potent inducer of differentiation of osteoblasts both in vivo and in vitro. We examined the action of BMP-2 on expression of a helix-loop-helix-type transcription factor, Id (inhibitor of differentiation), in osteoblast-like cells, as well as in osteoblast-enriched cells and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogata T,Wozney JM,Benezra R,Noda M

更新日期：1993-10-01 00:00:00

abstract：:Neural circuits are generated by precisely ordered synaptic connections among neurons, and this process is thought to rely on the ability of neurons to recognize specific partners. However, it is also known that neurons promiscuously form synapses with nonspecific partners, in particular when cultured in vitro, causin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ito S,Takeichi M

更新日期：2009-08-04 00:00:00

abstract：:The effect of fluctuations in rate constants on the kinetic behavior of cyclic reacting systems, caused by a fluctuating external parameter, is studied. It is shown (i) that the stochastic properties of the system can be analyzed analytically by using the usual master equation approach when the external parameter is f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD

更新日期：1987-02-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsilioni I,Pantazopoulos H,Conti P,Leeman SE,Theoharides TC

更新日期：2020-07-14 00:00:00

abstract：:It is now well established that glasses feature quasilocalized nonphononic excitations-coined "soft spots"-, which follow a universal [Formula: see text] density of states in the limit of low frequencies ω. All glass-specific properties, such as the dependence on the preparation protocol or composition, are encapsulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rainone C,Bouchbinder E,Lerner E

更新日期：2020-03-10 00:00:00

abstract：:Volcanic rifted margins are typically associated with a thick magmatic layer of seaward dipping reflectors and anomalous regional uplift. This is conventionally interpreted as due to melting of an arriving mantle plume head at the onset of rifting. However, seaward dipping reflectors and uplift are sometimes asymmetri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan JP,Taramón JM,Araujo M,Hasenclever J,Perez-Gussinye M

更新日期：2020-11-10 00:00:00

abstract：:The protein-protein interaction (PPI) network is crucial for cellular information processing and decision-making. With suitable inputs, PPI networks drive the cells to diverse functional outcomes such as cell proliferation or cell death. Here, we characterize the structural controllability of a large directed human PP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vinayagam A,Gibson TE,Lee HJ,Yilmazel B,Roesel C,Hu Y,Kwon Y,Sharma A,Liu YY,Perrimon N,Barabási AL

更新日期：2016-05-03 00:00:00

abstract：:The nucleotide and predicted amino acid sequences of two variant cDNAs [rat brain thyroid hormone receptor (rTR alpha) vI and vII], isolated from a rat brain cDNA library by using the Pst I fragment of v-erbA, showed virtual identity with the rat brain thyroid hormone receptor (rTR alpha) [Thompson, C. C., Weinberger,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitsuhashi T,Tennyson GE,Nikodem VM

更新日期：1988-08-01 00:00:00

abstract：:Although mind wandering occupies a large proportion of our waking life, its neural basis and relation to ongoing behavior remain controversial. We report an fMRI study that used experience sampling to provide an online measure of mind wandering during a concurrent task. Analyses focused on the interval of time immedia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christoff K,Gordon AM,Smallwood J,Smith R,Schooler JW

更新日期：2009-05-26 00:00:00

abstract：:Cocaine addiction and overdose have long defied specific treatment. To provide a new approach, the high-activity catalytic antibody mAb 15A10 was elicited using a transition-state analog for the hydrolysis of cocaine to nontoxic, nonaddictive products. In a model of cocaine overdose, mAb 15A10 protected rats from coca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mets B,Winger G,Cabrera C,Seo S,Jamdar S,Yang G,Zhao K,Briscoe RJ,Almonte R,Woods JH,Landry DW

更新日期：1998-08-18 00:00:00

abstract：:The toxic, mutagenic, and carcinogenic effects of alkylating agents have been attributed to their ability to damage DNA. Reaction at the O6 position of guanine results in miscoding during DNA replication, has been shown to be mutagenic in both bacteriophage and bacteria, and may be responsible for malignant transforma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennand J,Margison GP

更新日期：1986-09-01 00:00:00

abstract：:The activity of leukotriene A4 (LTA4) synthase in crude human leukocyte homogenates was found to have a similar requirement for Ca2+ and ATP as had been noted previously for 5-lipoxygenase activity. Purification of the 5-lipoxygenase using ammonium sulfate fractionation, AcA 44 gel-filtration chromatography, and HPLC ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rouzer CA,Matsumoto T,Samuelsson B

更新日期：1986-02-01 00:00:00

abstract：:We recently found that the beta-adrenergic agonist 1-isoproterenol evokes a rapid (less than 5 min) Ca2+- and receptor-dependent stimulation of endocytosis, hexose transport, and amino acid transport in mouse renal cortex involving proximal tubule cells. This response is associated with increased Ca2+ fluxes and a mob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koenig H,Goldstone AD,Lu CY

更新日期：1983-12-01 00:00:00

abstract：:Serotonin (5-HT) plays a key role in early brain development, and manipulation of 5-HT levels during this period can have lasting neurobiological and behavioral consequences. It is unclear how perinatal exposure to drugs, such as selective serotonin reuptake inhibitors (SSRIs), impacts cortical neural network function...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simpson KL,Weaver KJ,de Villers-Sidani E,Lu JY,Cai Z,Pang Y,Rodriguez-Porcel F,Paul IA,Merzenich M,Lin RC

更新日期：2011-11-08 00:00:00

abstract：:Barttin is an accessory subunit of a subgroup of ClC-type chloride channels expressed in renal and inner ear epithelia. In this study, we examined the effects of barttin on two ClC-K channel isoforms, rat ClC-K1 and human ClC-Kb, using heterologous expression, patch clamping, confocal imaging, and flow cytometry. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scholl U,Hebeisen S,Janssen AG,Müller-Newen G,Alekov A,Fahlke C

更新日期：2006-07-25 00:00:00

abstract：:Urbanization and rural-urban migration are two factors driving global patterns of disease and mortality. There is significant concern about their potential impact on disease burden and the effectiveness of current control approaches. Few attempts have been made to increase our understanding of the relationship between...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian H,Hu S,Cazelles B,Chowell G,Gao L,Laine M,Li Y,Yang H,Li Y,Yang Q,Tong X,Huang R,Bjornstad ON,Xiao H,Stenseth NC

更新日期：2018-05-01 00:00:00

abstract：:Mild oxidation of human serum low-density lipoprotein (LDL) converts the apoprotein from a nearly homogeneous component of high apparent molecular weight to a mixture of apparently lower molecular weight polypeptide components, as characterized by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. This protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schuh J,Fairclough GF Jr,Haschemeyer RH

更新日期：1978-07-01 00:00:00

abstract：:Depression, the most prevalent mental illness, is underdiagnosed and undertreated, highlighting the need to extend the scope of current screening methods. Here, we use language from Facebook posts of consenting individuals to predict depression recorded in electronic medical records. We accessed the history of Faceboo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eichstaedt JC,Smith RJ,Merchant RM,Ungar LH,Crutchley P,Preoţiuc-Pietro D,Asch DA,Schwartz HA

更新日期：2018-10-30 00:00:00

abstract：:Retroviruses undergo a high frequency of genetic alterations during the process of copying their RNA genomes. However, little is known about the replication fidelity of other elements that transpose via reverse transcription of an RNA intermediate. The complete sequence of 29 independently integrated copies of the yea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gabriel A,Willems M,Mules EH,Boeke JD

更新日期：1996-07-23 00:00:00

abstract：:This communication reports an analysis of Tn5/IS50 target site selection by using an extensive collection of Tn5 and IS50 insertions in two relatively small regions of DNA (less than 1 kb each). For both regions data were collected resulting from in vitro and in vivo transposition events. Since the data sets are consi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goryshin IY,Miller JA,Kil YV,Lanzov VA,Reznikoff WS

更新日期：1998-09-01 00:00:00

abstract：:Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, leading to cleavage of pro-IL-1β and pro-IL-18 and to pyroptosis, a proinflammatory cell death program. Although microbial recognition by Toll-like receptors (TLRs) is known to induce t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin KM,Hu W,Troutman TD,Jennings M,Brewer T,Li X,Nanda S,Cohen P,Thomas JA,Pasare C

更新日期：2014-01-14 00:00:00

abstract：:Control of the establishment of cell polarity is an essential function in tissue morphogenesis and renewal that depends on spatial cues provided by the extracellular environment. The molecular role of cell-cell or cell-extracellular matrix (ECM) contacts on the establishment of cell polarity has been well characterize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Théry M,Racine V,Piel M,Pépin A,Dimitrov A,Chen Y,Sibarita JB,Bornens M

更新日期：2006-12-26 00:00:00

abstract：:The avian predentary is a small skeletal structure located rostral to the paired dentaries found only in Mesozoic ornithuromorphs. The evolution and function of this enigmatic element is unknown. Skeletal tissues forming the predentary and the lower jaws in the basal ornithuromorph Yanornis martini are identified usin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailleul AM,Li Z,O'Connor J,Zhou Z

更新日期：2019-12-03 00:00:00

abstract：:Oxidative stress is known to cause tumorigenesis through induction of DNA and lipid damage. It also promotes cancer progression through a largely unknown mechanism. Sulfiredoxin (Srx) is a novel oxidative stress-induced antioxidant protein whose function in tumorigenesis and cancer progression has not been well studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei Q,Jiang H,Xiao Z,Baker A,Young MR,Veenstra TD,Colburn NH

更新日期：2011-04-26 00:00:00

abstract：:Mutations in the iPLA2-VIA/PLA2G6 gene are responsible for PARK14-linked Parkinson's disease (PD) with α-synucleinopathy. However, it is unclear how iPLA2-VIA mutations lead to α-synuclein (α-Syn) aggregation and dopaminergic (DA) neurodegeneration. Here, we report that iPLA2-VIA-deficient Drosophila exhibits defects ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mori A,Hatano T,Inoshita T,Shiba-Fukushima K,Koinuma T,Meng H,Kubo SI,Spratt S,Cui C,Yamashita C,Miki Y,Yamamoto K,Hirabayashi T,Murakami M,Takahashi Y,Shindou H,Nonaka T,Hasegawa M,Okuzumi A,Imai Y,Hattori N

更新日期：2019-10-08 00:00:00

abstract：:SoxR is a transcription factor that governs a global defense against the oxidative stress caused by nitric oxide or excess superoxide in Escherichia coli. SoxR is a homodimer containing a pair of [2Fe-2S] clusters essential for its transcriptional activity, and changes in the stability of these metal centers could con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding H,Demple B

更新日期：1996-09-03 00:00:00