High-dose epirubicin in the prophylactic treatment of T1G2 superficial bladder tumors.

Abstract:

OBJECTIVES:To evaluate the activity and safety of intravesical instillations of 80 mg epirubicin in a selected patient population with T1G2 primary and multiple superficial bladder tumors. To assess the completeness of the transurethral resection (TUR) at 4 weeks (second look) and to compare the histology of local and review pathology. METHODS:One hundred and sixty-nine patients have been histologically assessed both locally and extramurally for T1G2 superficial bladder tumors. Epirubicin (80 mg/instillation) started within 20 days after TUR was administered weekly during the first month and then monthly for another 11 months. Assessments for relapse were carried out according to the standard methods. RESULTS:Histological consistency for T1G2 between local and extramural assessments was found in 85.2% of cases. At the median follow-up time of 38 months, the overall relapse rate was 43.3%. Treatment was very well tolerated: no systemic adverse events were reported and local adverse events were confined to chemical cystitis which in 3% required treatment discontinuation. CONCLUSIONS:Epirubicin (80 mg/instillation) appeared effective in the prophylaxis of relapse in primary and multiple T1G2 superficial bladder tumors. A second TUR at 3-4 weeks is necessary in T1 tumors. Excellent concordance between local and review pathology was found.

journal_name

Eur Urol

journal_title

European urology

authors

Torelli F,Catanzaro F,Conti G,Comeri CG,Risi O,Pino R,Lissoni G,Borin R,Minocci D,Monesi G,Baresi A,Perego S,Caruso GM,Scardino G

doi

10.1159/000052551

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

11-4

eissn

0302-2838

issn

1873-7560

pii

52551

journal_volume

39 Suppl 2

pub_type

临床试验,杂志文章
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  • Innovations in Statistical Review at European Urology.

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    pub_type: 临床试验,杂志文章,随机对照试验

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  • EAU Guidelines on benign prostatic hyperplasia (BPH).

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    pub_type: 杂志文章

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    更新日期:2001-09-01 00:00:00

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    doi:

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    pub_type: 杂志文章,多中心研究

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    pub_type: 信件

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