Investigation of CMV disease in immunocompromised patients.

abstract：:The fetal antigen i has been demonstrated by indirect immunofluorescence on cord erythrocytes and placental trophoblast. A patient with disseminated choriocarcinoma developed high-tire anti-i cold agglutinins, and minor elevation of anti-i titres was seen in four out of six further patients with treated choriocarcinom...

journal_title：Journal of clinical pathology

authors： Boughton BJ

更新日期：1979-06-01 00:00:00

abstract：AIM:The rapid and fully automated Idylla EGFR Mutation Assay has been specifically designed to process formalin-fixed, paraffin-embedded sections without requiring preliminary DNA extraction. This study evaluates whether this approach can also process archival smears from patients with non-small cell lung cancer (NSCLC...

journal_title：Journal of clinical pathology

authors： De Luca C,Conticelli F,Leone A,Gragnano G,Salatiello M,Galasso P,Pisapia P,Grillo LR,Iaccarino A,Vigliar E,Bellevicine C,Malapelle U,Troncone G

更新日期：2019-09-01 00:00:00

abstract：AIMS:To determine important factors influencing recurrence after local excision of duct carcinoma in situ (DCIS) of the breast. MATERIALS AND METHODS:The extent (size) in millimetres, classification (by cytonuclear grade (NHSBSP system), by extent of necrosis, and by the Van Nuys system), and excision margins of 115 c...

journal_title：Journal of clinical pathology

authors： Douglas-Jones AG,Logan J,Morgan JM,Johnson R,Williams R

更新日期：2002-08-01 00:00:00

abstract：:KRAS mutation status predicts response to anti-EGFR therapy in colorectal cancer patients. Here we report an interesting case of discordant KRAS mutation status in a patient with two separate tumour foci. Tumour A in sigmoid colon invaded through muscularis propria into the subserosal fat with metastatic disease in re...

journal_title：Journal of clinical pathology

authors： Li X,Pezeshkpour G,Phan RT

更新日期：2015-01-01 00:00:00

abstract：AIMS:To determine whether myelodysplastic syndromes (MDS) are associated with sea blue histiocytosis in the bone marrow. METHODS:A retrospective review of bone marrow aspirates from 35 patients presenting consecutively with MDS and from 20 patients with each of the following: normal marrow appearance (routine staging ...

journal_title：Journal of clinical pathology

authors： Howard MR,Kesteven PJ

更新日期：1993-11-01 00:00:00

abstract：:Bone marrow infiltrates taken from 11 patients with peripheral T cell lymphoma were immunophenotyped as T cell lymphoma using monoclonal antibodies on frozen bone marrow trephine biopsy specimens. In nine these were taken at diagnosis and in two after failure of treatment to eradicate lymphoma in the marrow. Patterns ...

journal_title：Journal of clinical pathology

authors： White DM,Smith AG,Whitehouse JM,Smith JL

更新日期：1989-04-01 00:00:00

abstract：:The use of liquid media to detect the production of beta-lactamase by beta-lactamase producing organisms has been compared with the conventional method of inoculation on to agar media. Pharyngeal cultures were obtained from 162 children treated with penicillin for acute tonsillitis. beta-lactamase producing organisms ...

journal_title：Journal of clinical pathology

authors： Brook I,Gober AE

更新日期：1984-12-01 00:00:00

abstract：:Protein HC and protein HC-IgA complex were measured in 18 different types of fluid sample from healthy subjects and patients with different illnesses to determine if the concentrations of protein HC and protein HC-IgA complexes could be used to monitor certain diseases, when measured separately. The normal values for ...

journal_title：Journal of clinical pathology

authors： Fernández-Luna JL,Leyva-Cobián F,Méndez E

更新日期：1988-11-01 00:00:00

abstract：AIMS:To study the homozygous deletion and methylation status of the 5' CpG island of the p16 and p15 genes (9p21) in a set of primary advanced head and neck squamous cell carcinomas (SCC) and to test whether inactivation of these genes by these mechanisms contributes to head and neck SCC development. METHODS:DNA was e...

journal_title：Journal of clinical pathology

authors： González MV,Pello MF,López-Larrea C,Suárez C,Menéndez MJ,Coto E

更新日期：1997-06-01 00:00:00

abstract：:The morphological classification and diagnosis of bladder neoplasms is summarised, with specific focus on histological typing, grading and staging. Four diagnostic categories are described on the basis of the pattern of growth of the urothelial lesions and tumours (flat, exophytic or papillary, endophytic, and invasiv...

journal_title：Journal of clinical pathology

authors： Montironi R,Mazzucchelli R,Scarpelli M,Lopez-Beltran A,Cheng L

更新日期：2008-01-01 00:00:00

abstract：:In patients with chronic renal failure, blood samples for laboratory analysis are often taken via dialysis catheters. This report describes a case of gross spurious hypernatraemia in a blood sample collected from a patient undergoing haemodialysis. After centrifugation of the blood sample in question, the separator ge...

journal_title：Journal of clinical pathology

authors： Srivastava R,Murphy MJ,Card J,Severn A,Fraser CG

更新日期：2004-12-01 00:00:00

abstract：:The development of sensitive reagents and detection systems, together with the introduction of heat-induced antigen retrieval, has rapidly entrenched immunohistology as an indispensable adjunct to routine histological examination, contributing to diagnosis, prognosis and treatment. New antibodies continue to be produc...

journal_title：Journal of clinical pathology

authors： Leong AS,Leong TY

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Venous invasion (VI) is an important prognosis predictor after colorectal carcinoma (CRC) resection, enabling more accurate staging and influencing postoperative management. AIMS:To assess/compare various tissue block types (perpendicular, tangential, across mesentery (AM), from major vessels or lymph nodes...

journal_title：Journal of clinical pathology

authors： Sternberg A,Mizrahi A,Amar M,Groisman G

更新日期：2006-02-01 00:00:00

abstract：AIMS:To evaluate the Questor automated bacteriuria and pyuria screening system; to compare its performance with that of a reference method; and to assess its usefulness in a routine clinical laboratory. METHODS:The Questor urine screening system was compared with a comprehensive regimen to detect urinary tract infecti...

journal_title：Journal of clinical pathology

authors： Stevens M,Mitchell CJ,Livsey SA,MacDonald CA

更新日期：1993-09-01 00:00:00

abstract：:A case of chronic neutrophilic leukaemia (CNL) is reported. The diagnosis was based on leucocytosis with mature neutrophils, a raised leucocyte alkaline phosphatase score, negative Philadelphia chromosome, and extensive infiltration of neutrophils in various differentiation stages into the bone marrow. When viewed by ...

journal_title：Journal of clinical pathology

authors： Takemori N,Hirai K,Onodera R,Saito N,Namiki M

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Squamous differentiation/squamous metaplasia is often associated with endometrial adenocarcinoma and benign lesions, such as endometrial hyperplasia and chronic endometritis. Morules have distinct histological characteristics, and are referred to as squamous metaplasia or squamoid metaplasia. AIM:To focus o...

journal_title：Journal of clinical pathology

authors： Chinen K,Kamiyama K,Kinjo T,Arasaki A,Ihama Y,Hamada T,Iwamasa T

更新日期：2004-09-01 00:00:00

abstract：:Human sperm heads were detected and tracked using semiautomatic image analysis. Measurements of size and shape on two specimens from each of 26 men showed that the major component of variability both within and between subjects was the number of small elongated sperm heads. Variability of the computed features between...

journal_title：Journal of clinical pathology

authors： Jagoe JR,Washbrook NP,Hudson EA

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Thymidine phosphorylase (TP) is the key enzyme for capecitabine activation in tumour cells. AIMS:To examine whether TP expression in tumour cells and stroma is predictive of the tumour response to capecitabine plus docetaxel chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS...

journal_title：Journal of clinical pathology

authors： Han JY,Hong EK,Lee SY,Yoon SM,Lee DH,Lee JS

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:As the best characterised cancer/testis antigen family members, melanoma-associated antigens (MAGE) have been reported to be expressed in various malignant tumours. However, the expression pattern of MAGE-A family in lung adenocarcinoma (LAC) specimens and their prognostic and therapeutic significance for pa...

journal_title：Journal of clinical pathology

authors： Sang M,Gu L,Yin D,Liu F,Lian Y,Zhang X,Liu S,Huang W,Wu Y,Shan B

更新日期：2017-06-01 00:00:00

abstract：:This best practice review examines four series of common primary care questions in laboratory medicine: (i) "minor" blood platelet count and haemoglobin abnormalities; (ii) diagnosis and monitoring of anaemia caused by iron deficiency; (iii) secondary hyperlipidaemia and hypertriglyceridaemia; and (iv) glycated haemog...

journal_title：Journal of clinical pathology

authors： Smellie WS,Forth J,Bareford D,Twomey P,Galloway MJ,Logan EC,Smart SR,Reynolds TM,Waine C

更新日期：2006-08-01 00:00:00

abstract：:A locally developed, computer-based clinical chemistry laboratory system has been in operation since 1970. This utilises a Digital Equipment Co Ltd PDP 12 and an interconnected PDP 8/F computer. Details are presented of the performance and quality control techniques incorporated into the system. Laboratory performance...

journal_title：Journal of clinical pathology

authors： Undrill PE,Frazer SC

更新日期：1979-02-01 00:00:00

abstract：:The ability of erythrocytes to synthesize porphyrins from delta-aminolaevulic acid was compared in healthy people, patients with true iron-deficiency anaemia, and anaemic patients with rheumatoid arthritis. Porphyrin synthesis was found to be impaired in true iron deficiency but not in rheumatoid arthritis cases showi...

journal_title：Journal of clinical pathology

authors： Gutniak O,Kopéc M,Nieczaj J

更新日期：1971-05-01 00:00:00

abstract：:This review of the histomorphometry of bone outlines methods of biopsy and processing of specimens in the laboratory, the basic principles of morphometry, and the measurements made in order to obtain estimates of the proportional volumes and surfaces occupied by different components of bone. Variability such as that b...

journal_title：Journal of clinical pathology

authors： Revell PA

更新日期：1983-12-01 00:00:00

abstract：:The haematological features of 118 cases of primary myelodysplastic syndromes (PMDS) were reviewed to see how these could be related and classified according to the recent FAB proposals. A majority of the cases were elderly who presented with a macrocytic or normocytic anaemia and reticulocytopenia. Cases of acquired ...

journal_title：Journal of clinical pathology

authors： Juneja SK,Imbert M,Jouault H,Scoazec JY,Sigaux F,Sultan C

更新日期：1983-10-01 00:00:00

abstract：:Haematological malignancies are a diverse group of cancers that affect the blood, bone marrow and lymphatic systems. Laboratory diagnosis of haematological malignancies is dependent on combining several technologies, including morphology, immunophenotyping, cytogenetics and molecular genetics correlated clinical detai...

journal_title：Journal of clinical pathology

authors： Snowden JA,O'Connell S,Hawkins J,Dalley C,Jack A,Mannari D,McNamara C,Scott M,Shenton G,Soilleux E,Macbeth F,Guideline Committee.

更新日期：2017-06-01 00:00:00

abstract：:Sentinel lymph node biopsy is a novel method for the surgical management of patients with cervical cancer. Sentinel nodes have a higher chance of harbouring metastases than non-sentinel nodes. Assessment of sentinel nodes provides an opportunity to stage patients intraoperatively and avoid complete pelvic lymph node d...

journal_title：Journal of clinical pathology

authors： Rasty G,Hauspy J,Bandarchi B

更新日期：2009-12-01 00:00:00

abstract：:Blood cultures drawn from a patient with clinically diagnosed invasive meningococcal disease, who had been previously administered benzylpenicillin, had beta-lactamases added to increase the probability of recovery of the causative organism. The blood cultures subsequently yielded Neisseria meningitidis but direct sus...

journal_title：Journal of clinical pathology

authors： Weightman NC

更新日期：2001-11-01 00:00:00

abstract：:The results of an investigation show that there is no statistically significant excess of blood group A in cases of carcinoma of the oesophagus or in cases of benign prostatic hyperplasia. ...

journal_title：Journal of clinical pathology

authors： BEASLEY WH

更新日期：1964-01-01 00:00:00

abstract：:A method is described of measuring the response of human lymphocytes to phytohaemagglutinin stimulation using iododeoxyuridine labelled with the gamma-emitting isotope (125)I. The results indicate useful clinical applications. ...

journal_title：Journal of clinical pathology

authors： Craig AW,Garrett JV,Jackson SM

更新日期：1969-09-01 00:00:00

abstract：:An unusually severe hypersensitivity reaction to carbamazepine is described, in which the patient presented with lymphadenopathy, hepatosplenomegaly, bone marrow suppression, immunosuppression and other features strongly suggestive of a lymphoma. ...

journal_title：Journal of clinical pathology

authors： Yates P,Stockdill G,McIntyre M

更新日期：1986-11-01 00:00:00