Best practice in primary care pathology: review 3.

abstract：OBJECTIVES:To evaluate the protein expression of connexin 43 (Cx43) in primary urothelial bladder cancer and test its association with the histopathological characteristics and clinical outcome. METHODS:A tissue microarray containing 348 tissue samples from 174 patients with primary urothelial carcinomas of the bladde...

journal_title：Journal of clinical pathology

authors： Poyet C,Buser L,Roudnicky F,Detmar M,Hermanns T,Mannhard D,Höhn A,Rüschoff J,Zhong Q,Sulser T,Moch H,Wild PJ

更新日期：2015-10-01 00:00:00

abstract：:The detection of lymphoid cells by routine examination of the urine after renal allotransplantation has proved to be a useful early indication of rejection. In a study of 36 rejection episodes, 20 (56%) were associated with a significant number of lymphocytes in the urine. The incidence was much higher when rejection ...

journal_title：Journal of clinical pathology

authors： Papadimitriou M,Chisholm GD,Kulatilake AE,Shackman R

更新日期：1970-03-01 00:00:00

abstract：BACKGROUND:Periostin is a secreted adhesion protein, normally expressed in mesenchime-derived cells. Aberrant expression of the periostin gene in epithelial tumours seems to play a role in angiogenesis and metastases. AIMS:To investigate periostin expression in a consecutive series of breast carcinomas and correlate i...

journal_title：Journal of clinical pathology

authors： Puglisi F,Puppin C,Pegolo E,Andreetta C,Pascoletti G,D'Aurizio F,Pandolfi M,Fasola G,Piga A,Damante G,Di Loreto C

更新日期：2008-04-01 00:00:00

abstract：:One hundred prostates from 20 to 40 year old men obtained at necropsy were completely sectioned and studied microscopically. Atypical hyperplasia was found in 10 (20%) of 20-29 year old men and in 12 (24%) of 30-40 year old men. The prostates with atypical hyperplasia had similar weights as those without, and the atyp...

journal_title：Journal of clinical pathology

authors： Brawn PN,Speights VO,Contin JU,Bayardo RJ,Kuhl DL

更新日期：1989-04-01 00:00:00

abstract：:Superficial inflammatory dermatoses are very common and comprise a wide, complex variety of clinical conditions. Accurate histological diagnosis, although it can sometimes be difficult to establish, is essential for clinical management. Knowledge of the microanatomy of the skin is important to recognise the variable h...

journal_title：Journal of clinical pathology

authors： Alsaad KO,Ghazarian D

更新日期：2005-12-01 00:00:00

abstract：:A technique is described for obtaining samples of bladder epithelium using soluble swabs. Changes indicating neoplasia were seen in a large proportion of patients with bladder carcinoma. These changes were absent in the non-neoplastic control cases. The method provided tissue similar to that obtained by biopsy and sur...

journal_title：Journal of clinical pathology

authors： Trott PA,Williams G,Attridge PW

更新日期：1969-11-01 00:00:00

abstract：:Gastrointestinal (GI) symptoms including abdominal pain, bloating and diarrhoea are a relatively common reason for consulting a physician. They may be due to inflammatory bowel disease (inflammatory bowel disease; Crohn's disease, ulcerative colitis and indeterminate colitis), malignancy (colorectal cancer), infectiou...

journal_title：Journal of clinical pathology

authors： Sherwood RA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterised by the presence of various laboratory abnormalities but the precise role of laboratory staff in initiating clinical referral and subsequent biopsy is not clear. OBJECTIVE:To examine the impact of laboratory abnormalities in the inv...

journal_title：Journal of clinical pathology

authors： Sinclair D,Spedding A,Young R

更新日期：2006-04-01 00:00:00

abstract：:The serotype of 320 strains of Proteus mirabilis from clinical material was determined. Using 20 O antisera and four H antisera 61% of strains could be fully identified and 90% partially identified. A large number of serotypes were recognized but no difference was found between the serotype of organisms infecting the ...

journal_title：Journal of clinical pathology

authors： De Louvois J

更新日期：1969-05-01 00:00:00

abstract：BACKGROUND:Some uterine endometrioid adenocarcinomas exhibit a distinctive morphological phenotype characterised by the formation of microcystic, elongated and fragmented (MELF) glands. Immunohistochemical studies have suggested that MELF-type changes represent an epithelial-mesenchymal transition which has been associ...

journal_title：Journal of clinical pathology

authors： Stewart CJ,Amanuel B,Grieu F,Carrello A,Iacopetta B

更新日期：2010-07-01 00:00:00

abstract：:The peripheral lymphocytes of 50 cases of human immunodeficiency virus (HIV) infection (13 of acquired immune deficiency syndrome (AIDS), 17 of AIDS related complex (ARC), and 20 healthy carriers) were studied immunoultrastructurally. The prevalence of "tubuloreticular structures" and "tubular confronting cisternae" i...

journal_title：Journal of clinical pathology

authors： Feremans WW,Huygen K,Menu R,Farber CM,de Caluwe JP,van Vooren JP,Marcelis L,Andre L,Brasseur M,Bondue H

更新日期：1988-01-01 00:00:00

abstract：:Tumour associated antigens recognised by cellular or humoral effectors of the immune system are potential targets for antigen specific cancer immunotherapy. Different categories of cancer antigens have been identified that induce cytotoxic T lymphocyte (CTL) responses in vitro and in vivo, namely: (1) "cancer testis" ...

journal_title：Journal of clinical pathology

authors： Jäger D,Jäger E,Knuth A

更新日期：2001-09-01 00:00:00

abstract：:A microcomputer system for use in the sequential processing of specimens has been developed in a hospital microbiology department which receives 90 000 specimens a year. Data handling is performed directly through the computers without the use of cards or worksheets. The system facilitates the multistep processing of ...

journal_title：Journal of clinical pathology

authors： Ashley R,Downing B

更新日期：1985-02-01 00:00:00

abstract：AIMS:Dysfunctional prothrombin residue Arg596 associated mutation has been found to precipitate venous thromboembolism (VTE). In the current study we investigated the prevalence of Arg596 associated mutations in Chinese patients with VTE and explored the functional impact of Arg596Gln mutation on coagulation function i...

journal_title：Journal of clinical pathology

authors： Wu X,Li L,Ding Q,Wang X,Wu F,Wu W

更新日期：2018-07-01 00:00:00

abstract：:Enteroviruses are rare causes of acute focal encephalitis. A fatal case of echovirus type 9 infection is reported in a 9 month old boy who presented with a fever and a macular rash followed by two focal seizures. Echovirus type 9 was isolated from lung tissue after seven days. ...

journal_title：Journal of clinical pathology

authors： Zuckerman MA,Sheaff M,Martin JE,Gabriel CM

更新日期：1993-09-01 00:00:00

abstract：AIM:To establish whether infection with Epstein-Barr virus (EBV) contributed to the development of coronary artery lesions in a six year old child with an aneurysm and stenoses of the coronary arteries and suspected Kawasaki disease. METHODS:Postmortem paraffin wax sections of the coronary artery and myocardium were e...

journal_title：Journal of clinical pathology

authors： Culora GA,Moore IE

更新日期：1997-02-01 00:00:00

abstract：:This review deals with difficulties of diagnosis in cutaneous malignant melanoma encountered by histopathologists of variable seniority and is based on referred material at The Royal Marsden Hospital over a 20-year period and on the experience of more than two-and-a-half thousand cases referred to The World Health Org...

journal_title：Journal of clinical pathology

authors： Levene A

更新日期：1980-02-01 00:00:00

abstract：AIMS:To detect cells bearing BRAF mutations in colorectal tumour samples and peritoneal washings, using a mismatch ligation assay (MLA). METHODS:DNA from 46 colorectal tumours was studied. Part of exon 15 of the BRAF gene was amplified using the polymerase chain reaction, and T-->A mutations at codon 600 were detected...

journal_title：Journal of clinical pathology

authors： Busby K,Morris A

更新日期：2005-04-01 00:00:00

abstract：:Twenty-two known strains of the Bacteroides fragilis group of organisms and 67 clinical specimens from a variety of sites were examined by fluorescent antibody test (IFA) using two different antisera fro the rapid detection of B fragilis group of organisms. A previously reported Barts' pooled antisera was compared wit...

journal_title：Journal of clinical pathology

authors： Wills A,Taylor E,Pantosti A,Phillips I,Tabaqchali S

更新日期：1982-03-01 00:00:00

abstract：:Tissue microarray (TMA) is an established and valuable tool, particularly in translational research and clinical trials, allowing resource-efficient use, and high-throughput profiling, of large numbers of tumours. Despite this, there is little evidence, or guidance, on the optimum manufacture, use and assessment of TM...

journal_title：Journal of clinical pathology

authors： Pinder SE,Brown JP,Gillett C,Purdie CA,Speirs V,Thompson AM,Shaaban AM,Translational Subgroup of the NCRI Breast Clinical Studies Group.

更新日期：2013-03-01 00:00:00

abstract：:Several DNA extraction techniques were quantitatively and qualitatively compared using both fresh and paraffin wax embedded tissue and their suitability investigated for providing DNA and RNA for the polymerase chain reaction (PCR). A one hour incubation with proteinase K was the most efficient DNA extraction procedur...

journal_title：Journal of clinical pathology

authors： Jackson DP,Lewis FA,Taylor GR,Boylston AW,Quirke P

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate the need for routine histopathological analysis of enucleated/eviscerated eyes and changes in indications for eye removal. METHODS:Retrospective review of all enucleation/evisceration histopathology reports over 20 years. Clinical history was correlated with pathological findings. Two 10 ye...

journal_title：Journal of clinical pathology

authors： Saeed MU,Chang BY,Khandwala M,Shivane AG,Chakrabarty A

更新日期：2006-02-01 00:00:00

abstract：:The clinical and pathological findings in 23 patients with ischaemic lesions of the alimentary tract (ischaemic enterocolitis) are described. These are compared with findings in 13 patients with occlusive thrombosis of the superior mesenteric artery. The pathological features distinguishing the two conditions are disc...

journal_title：Journal of clinical pathology

authors： McDonald GS,Hourihane DO

更新日期：1972-02-01 00:00:00

abstract：BACKGROUND/AIMS:Mast cells, when activated, secrete a large number of fibrogenic factors and have been implicated in the development of fibrotic conditions of the liver, lung, and skin. There is evidence that renal fibrosis is closely linked with a chronic inflammatory cell infiltrate within the interstitium, but a pot...

journal_title：Journal of clinical pathology

authors： Roberts IS,Brenchley PE

更新日期：2000-11-01 00:00:00

abstract：:Members of a newly recognized group of hospital staphylococci, which are believed to have arisen from 83A staphylococci by lysogenization, differ from them in several cultural characters. Some but not all of these characters appear to be determined by the carriage of phage. ...

journal_title：Journal of clinical pathology

authors： Jevons MP,John M,Parker MT

更新日期：1966-07-01 00:00:00

abstract：:Clonality analysis of the immunoglobulin heavy chain (IgH) gene is helpful in identifying malignant B cell infiltrates in the bone marrow and is usually carried out on separate aspirates or on the same formalin-fixed decalcified bone marrow specimen. To determine whether the removal of the decalcification step would i...

journal_title：Journal of clinical pathology

authors： Parrens M,Carrere N,Bouabdallah K,Fitoussi O,Goussot JF,Dubus P,de Mascarel A,Merlio JP

更新日期：2006-10-01 00:00:00

abstract：AIMS:To isolate RNA and DNA simultaneously from formalin fixed paraffin wax embedded tissue to assess the clonality of enteropathy associated T cell lymphomas and to analyse it in detail by a non-radioactive method of T cell receptor complementarity determining region 3 (CDR3) spectratyping. METHODS:DNA and RNA were i...

journal_title：Journal of clinical pathology

authors： O'Shea U,Wyatt JI,Howdle PD

更新日期：1997-10-01 00:00:00

abstract：AIMS:To determine prognostic significance of immunohistochemical markers and investigate possible germinal centre (GC) derivation in primary lymphoma of bone (PLB). METHODS:Immunohistochemical expression of BCL-6, CD10, BCL-2, p53, CD30, CD44 and MUM-1 was studied in 36 patients with PLB. All cases were clinically sta...

journal_title：Journal of clinical pathology

authors： Heyning FH,Hogendoorn PC,Kramer MH,Holland CT,Dreef E,Jansen PM

更新日期：2009-09-01 00:00:00

abstract：:The term "dysplastic" melanocytic naevus has recently been used to describe pigmented naevi with unusual histological and clinical features. There is currently no clear clinical or pathological definition of the term, and this has led to a lack of comparability of material described in reports on these lesions. As a r...

journal_title：Journal of clinical pathology

authors： Seywright MM,Doherty VR,MacKie RM

更新日期：1986-02-01 00:00:00

abstract：:A biochemical typing method is described for Klebsiella pneumoniae (sensu lato) and Enterobacter aerogenes. The technique depends on differences in metabolism of five carbon substrates--glycerol, inositol, lactose, glucose, and xylose--at two concentrations. Reproducibility is satisfactory and is monitored by the inco...

journal_title：Journal of clinical pathology

authors： Barr JG,Hogg GM

更新日期：1979-09-01 00:00:00