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Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.

Abstract：

:Recent research has emphasized the importance of the metabolic cluster, which includes glucose intolerance, dyslipidemia, and high blood pressure, as a strong predictor of the obesity-related morbidities and premature mortality. Fundamental to this association, commonly referred to as the metabolic syndrome, is the close interaction between abdominal fat patterning, total body adiposity, and insulin resistance. As the initial step in identifying major genetic loci influencing these phenotypes, we performed a genomewide scan by using a 10-centiMorgan map in 2,209 individuals distributed over 507 nuclear Caucasian families. Pedigree-based analysis using a variance components linkage model demonstrated a quantitative trait locus (QTL) on chromosome 3 (3q27) strongly linked to six traits representing these fundamental phenotypes [logarithm of odds (lod) scores ranged from 2.4 to 3.5]. This QTL exhibited possible epistatic interaction with a second QTL on chromosome 17 (17p12) strongly linked to plasma leptin levels (lod = 5.0). Situated at these epistatic QTLs are candidate genes likely to influence two biologic precursor pathways of the metabolic syndrome.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Kissebah AH,Sonnenberg GE,Myklebust J,Goldstein M,Broman K,James RG,Marks JA,Krakower GR,Jacob HJ,Weber J,Martin L,Blangero J,Comuzzie AG

doi

10.1073/pnas.97.26.14478

keywords:

subject

Has Abstract

pub_date

2000-12-19 00:00:00

pages

14478-83

issue

26

eissn

0027-8424

issn

1091-6490

pii

97/26/14478

journal_volume

97

pub_type

杂志文章

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