Effect of Daucus carota var. boissieri extracts on immune response of Schistosoma mansoni infected mice.

Abstract:

:Isolation and structure elucidation was carried out of flavonoid constituents found in fractionated extracts of the seeds and green leaves of Daucus carota L. var. boissieri (Apiaceae). The flavonoids are mainly apigenin, luteolin, their glycosidic precursors and 2,4,5-trimethoxybenzaldehyde. Fatty acids, hydrocarbons and sterols were identified by GLC. The effect of various carrot extracts on the immune responses of Schistosoma mansoni infected mice was studied. The rate of reduction in worm infestation in mice injected with some fractions indicated a strong protection. Some extracts induced humoral immune response through raising the IgG level at 2, 4 and 6 weeks post-infection as compared with infected control. The phenotypic analysis of the cellular immune response in spleen and mesenteric lymph nodes was accomplished by direct immunofluorescence. The data showed that some extracts stimulated the blastogenesis of CD4(+)-T splenocytes and mesenteric lymph node cells.

journal_title

Folia microbiologica

authors

Shalaby NM,Maghraby AS,el-Hagrassy AM

doi

10.1007/BF02903720

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

441-8

issue

4

eissn

0015-5632

issn

1874-9356

journal_volume

44

pub_type

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