Effects of canine distemper virus infection on lymphoid function in vitro and in vivo.

Abstract:

:In the present study, the immunodepressive effects of canine distemper virus (CDV) infection of dogs on two parameters of lymphocyte function, namely phytomitogen-induced cellular proliferation and skin allograft rejection, were investigated. Infection of susceptible gnotobiotic dogs with virulent R252-CDV resulted in a depression of peripheral blood lymphocyte mitogen response as measured by (3H)thymidine incorporation for up to 10 weeks after inoculation. This effect coincided with the appearance of viral antigen by immunofluorescence in leukocytes but persisted after the virus was no longer detectable. Loss of mitogen reactivity was seen in all infected dogs. However, when these same CDV-infected dogs were challenged with foreign skin allografts, no significant retention of grafts over controls was observed despite the depressed lymphocyte activity. Considering the in vitro and in vivo data it was concluded that, although immunodepressive effects of CDV were demonstrated in vitro, paralled in vivo experiments indicated that less than complete suppression of immune functions occurs during the course of CDV infection.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Krakowka S,Cockerell G,Koestner A

doi

10.1128/IAI.11.5.1069-1078.1975

keywords:

subject

Has Abstract

pub_date

1975-05-01 00:00:00

pages

1069-78

issue

5

eissn

0019-9567

issn

1098-5522

journal_volume

11

pub_type

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